| Identification |
|---|
| HMDB Protein ID
| CDBP04591 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histone acetyltransferase type B catalytic subunit |
| Description
| Not Available |
| Synonyms
|
- SubName: Histone acetyltransferase 1, isoform CRA_b
- Histone acetyltransferase 1
|
| Gene Name
| HAT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in histone acetyltransferase activity |
| Specific Function
| Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.
|
| GO Classification
|
| Biological Process |
| DNA packaging |
| response to nutrient |
| chromatin silencing at telomere |
| Cellular Component |
| cytoplasm |
| nucleus |
| nucleoplasm |
| nuclear matrix |
| Function |
| lysine n-acetyltransferase activity |
| histone acetyltransferase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| transferase activity, transferring acyl groups other than amino-acyl groups |
| acyltransferase activity |
| acetyltransferase activity |
| n-acetyltransferase activity |
| Molecular Function |
| histone acetyltransferase activity |
| Process |
| cellular process |
| cellular component organization at cellular level |
| organelle organization |
| chromosome organization |
| chromatin organization |
| chromatin modification |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Alcoholism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q31.2-q33.1 |
| SNPs
| HAT1 |
| Gene Sequence
|
>1005 bp
ATGTTCCGTGTTGAATATGCATCTAAAGTTGATGAGAACTTTGACTGTGTAGAGGCAGAT
GATGTTGAGGGCAAAATTAGACAAATCATTCCACCTGGATTTTGCACAAACACGAATGAT
TTCCTTTCTTTACTGGAAAAGGAAGTTGATTTCAAGCCATTCGGAACCTTACTTCATACC
TACTCAGTTCTCAGTCCAACAGGAGGAGAAAACTTTACCTTTCAGATATATAAGGCTGAC
ATGACATGTAGAGGCTTTCGAGAATATCATGAAAGGCTTCAGACCTTTTTGATGTGGTTT
ATTGAAACTGCTAGCTTTATTGACGTGGATGATGAAAGATGGCACTACTTTCTAGTATTT
GAGAAGTATAATAAGGATGGAGCTACGCTCTTTGCGACCGTAGGCTACATGACAGTCTAT
AATTACTATGTGTACCCAGACAAAACCCGGCCACGTGTAAGTCAGATGCTGATTTTGACT
CCATTTCAAGGTCAAGGCCATGGTGCTCAACTTCTTGAAACAGTTCATAGATACTACACT
GAATTTCCTACAGTTCTTGATATTACAGCGGAAGATCCATCCAAAAGCTATGTGAAATTA
CGAGACTTTGTGCTTGTGAAGCTTTGTCAAGATTTGCCCTGTTTTTCCCGGGAAAAATTA
ATGCAAGGATTCAATGAAGATATGGCGATAGAGGCACAACAGAAGTTCAAAATAAATAAG
CAACACGCTAGAAGGGTTTATGAAATTCTTCGACTACTGGTAACTGACATGAGTGATGCC
GAACAATACAGAAGCTACAGACTGGATATTAAAAGAAGACTAATTAGCCCATATAAGAAA
AAGCAGAGAGATCTTGCTAAGATGAGAAAATGTCTCAGACCAGAAGAACTGACAAACCAG
ATGAACCAAATAGAAATAAGCATGCAACATGAACAGCTGGAAGAGAGTTTTCAGGAACTA
GTGGAAGATTACCGGCGTGTTATTGAACGACTTGCTCAAGAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 334 |
| Molecular Weight
| 49512.19 |
| Theoretical pI
| 5.699 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histone acetyltransferase 1
MFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKEVDFKPFGTLLHT
YSVLSPTGGENFTFQIYKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVF
EKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYT
EFPTVLDITAEDPSKSYVKLRDFVLVKLCQDLPCFSREKLMQGFNEDMAIEAQQKFKINK
QHARRVYEILRLLVTDMSDAEQYRSYRLDIKRRLISPYKKKQRDLAKMRKCLRPEELTNQ
MNQIEISMQHEQLEESFQELVEDYRRVIERLAQE
|
| External Links |
|---|
| GenBank ID Protein
| 38614185 |
| UniProtKB/Swiss-Prot ID
| O14929 |
| UniProtKB/Swiss-Prot Entry Name
| Q6P594_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC063003 |
| GeneCard ID
| HAT1 |
| GenAtlas ID
| HAT1 |
| HGNC ID
| HGNC:4821 |
| References |
|---|
| General References
| Not Available |