Cannabis Compound Database: Showing Protein Diacylglycerol O-acyltransferase 1 (CDBP00237)

Identification Biological properties Gene properties Protein properties External links References XML Show 681 compounds

Identification

HMDB Protein ID

CDBP00237

Secondary Accession Numbers

Not Available

Name

Diacylglycerol O-acyltransferase 1

Description

Not Available

Synonyms

ACAT-related gene product 1
Diglyceride acyltransferase
Acyl-CoA retinol O-fatty-acyltransferase
ARAT
Retinol O-fatty-acyltransferase

Gene Name

DGAT1

Protein Type

Enzyme

Biological Properties

General Function

Involved in diacylglycerol O-acyltransferase activity

Specific Function

Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.

GO Classification

Biological Process
acylglycerol acyl-chain remodeling
diacylglycerol metabolic process
glycerophospholipid biosynthetic process
insulin secretion
triglyceride biosynthetic process
small molecule metabolic process
lipid storage
long-chain fatty-acyl-CoA metabolic process
fatty acid homeostasis
very-low-density lipoprotein particle assembly
Cellular Component
endoplasmic reticulum membrane
integral to membrane
Molecular Function
diacylglycerol binding
fatty acid binding
2-acylglycerol O-acyltransferase activity
diacylglycerol O-acyltransferase activity
retinol O-fatty-acyltransferase activity

Cellular Location

Endoplasmic reticulum membrane
Multi-pass membrane protein

Pathways

Name	SMPDB/Pathwhiz	KEGG
Retinol Metabolism
Fat digestion and absorption	Not Available
Vitamin A Deficiency		Not Available
De Novo Triacylglycerol Biosynthesis		Not Available
De Novo Triacylglycerol Biosynthesis TG(10:0/10:0/10:0)		Not Available

Gene Properties

Chromosome Location

Locus

8q24.3

SNPs

DGAT1

Gene Sequence

>1467 bp
ATGGGCGACCGCGGCAGCTCCCGGCGCCGGAGGACAGGGTCGCGGCCCTCGAGCCACGGC
GGCGGCGGGCCTGCGGCGGCGGAAGAGGAGGTGCGGGACGCCGCTGCGGGCCCCGACGTG
GGAGCCGCGGGGGACGCGCCAGCCCCGGCCCCCAACAAGGACGGAGACGCCGGCGTGGGC
AGCGGCCACTGGGAGCTGAGGTGCCATCGCCTGCAGGATTCTTTATTCAGCTCTGACAGT
GGCTTCAGCAACTACCGTGGCATCCTGAACTGGTGTGTGGTGATGCTGATCTTGAGCAAT
GCCCGGTTATTTCTGGAGAACCTCATCAAGTATGGCATCCTGGTGGACCCCATCCAGGTG
GTTTCTCTGTTCCTGAAGGATCCCTATAGCTGGCCCGCCCCATGCCTGGTTATTGCGGCC
AATGTCTTTGCTGTGGCTGCATTCCAGGTTGAGAAGCGCCTGGCGGTGGGTGCCCTGACG
GAGCAGGCGGGACTGCTGCTGCACGTGGCCAACCTGGCCACCATTCTGTGTTTCCCAGCG
GCTGTGGTCTTACTGGTTGAGTCTATCACTCCAGTGGGCTCCCTGCTGGCGCTGATGGCG
CACACCATCCTCTTCCTCAAGCTCTTCTCCTACCGCGACGTCAACTCATGGTGCCGCAGG
GCCAGGGCCAAGGCTGCCTCTGCAGGGAAGAAGGCCAGCAGTGCTGCTGCCCCGCACACC
GTGAGCTACCCGGACAATCTGACCTACCGCGATCTCTACTACTTCCTCTTCGCCCCCACC
TTGTGCTACGAGCTCAACTTTCCCCGCTCTCCCCGCATCCGGAAGCGCTTTCTGCTGCGA
CGGATCCTTGAGATGCTGTTCTTCACCCAGCTCCAGGTGGGGCTGATCCAGCAGTGGATG
GTCCCCACCATCCAGAACTCCATGAAGCCCTTCAAGGACATGGACTACTCACGCATCATC
GAGCGCCTCCTGAAGCTGGCGGTCCCCAATCACCTCATCTGGCTCATCTTCTTCTACTGG
CTCTTCCACTCCTGCCTGAATGCCGTGGCTGAGCTCATGCAGTTTGGAGACCGGGAGTTC
TACCGGGACTGGTGGAACTCCGAGTCTGTCACCTACTTCTGGCAGAACTGGAACATCCCT
GTGCACAAGTGGTGCATCAGACACTTCTACAAGCCCATGCTTCGACGGGGCAGCAGCAAG
TGGATGGCCAGGACAGGGGTGTTCCTGGCCTCGGCCTTCTTCCACGAGTACCTGGTGAGC
GTCCCTCTGCGAATGTTCCGCCTCTGGGCGTTCACGGGCATGATGGCTCAGATCCCACTG
GCCTGGTTCGTGGGCCGCTTTTTCCAGGGCAACTATGGCAACGCAGCTGTGTGGCTGTCG
CTCATCATCGGACAGCCAATAGCCGTCCTCATGTACGTCCACGACTACTACGTGCTCAAC
TATGAGGCCCCAGCGGCAGAGGCCTGA

Protein Properties

Number of Residues

488

Molecular Weight

55277.735

Theoretical pI

9.32

Pfam Domain Function

MBOAT (PF03062 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Diacylglycerol O-acyltransferase 1
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA

External Links

GenBank ID Protein

29170487

UniProtKB/Swiss-Prot ID

O75907

UniProtKB/Swiss-Prot Entry Name

DGAT1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AB057815

GeneCard ID