Cannabis Compound Database: Showing Protein Acetyl-CoA acetyltransferase, mitochondrial (CDBP00036)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00036

Secondary Accession Numbers

Not Available

Name

Acetyl-CoA acetyltransferase, mitochondrial

Description

Not Available

Synonyms

Acetoacetyl-CoA thiolase
T2

Gene Name

ACAT1

Protein Type

Enzyme

Biological Properties

General Function

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific Function

Plays a major role in ketone body metabolism.

GO Classification

Biological Process
response to hormone stimulus
ketone body biosynthetic process
ketone body catabolic process
adipose tissue development
liver development
response to starvation
protein homooligomerization
brain development
response to organic cyclic compound
cellular lipid metabolic process
metanephric proximal convoluted tubule development
branched-chain amino acid catabolic process
cellular nitrogen compound metabolic process
Cellular Component
mitochondrial matrix
mitochondrial inner membrane
Function
transferase activity, transferring acyl groups other than amino-acyl groups
catalytic activity
transferase activity
transferase activity, transferring acyl groups
Molecular Function
metal ion binding
acetyl-CoA C-acetyltransferase activity
coenzyme binding
Process
metabolic process

Cellular Location

Mitochondrion

Pathways

Name	SMPDB/Pathwhiz	KEGG
Synthesis and degradation of ketone bodies	Not Available
Glyoxylate and dicarboxylate metabolism	Not Available
Butanoate metabolism	Not Available
Terpenoid backbone biosynthesis	Not Available
Butyrate Metabolism

Gene Properties

Chromosome Location

Locus

11q22.3

SNPs

ACAT1

Gene Sequence

>1284 bp
ATGGCTGTGCTGGCGGCACTTCTGCGCAGCGGCGCCCGCAGCCGCAGCCCCCTGCTCCGG
AGGCTGGTGCAGGAAATAAGATATGTGGAACGGAGTTATGTATCAAAACCCACTTTGAAG
GAAGTGGTCATAGTAAGTGCTACAAGAACACCCATTGGATCTTTTTTAGGCAGCCTTTCC
TTGCTGCCAGCCACTAAGCTTGGTTCCATTGCAATTCAGGGAGCCATTGAAAAGGCAGGG
ATTCCAAAAGAAGAAGTGAAAGAAGCATACATGGGTAATGTTCTACAAGGAGGTGAAGGA
CAAGCTCCTACAAGGCAGGCAGTATTGGGTGCAGGCTTACCTATTTCTACTCCATGTACC
ACCATAAACAAAGTTTGTGCTTCAGGAATGAAAGCCATCATGATGGCCTCTCAAAGTCTT
ATGTGTGGACATCAGGATGTGATGGTGGCAGGTGGGATGGAGAGCATGTCCAATGTTCCA
TATGTAATGAACAGAGGATCAACACCATATGGTGGGGTAAAGCTTGAAGATTTGATTGTA
AAAGACGGGCTAACTGATGTCTACAATAAAATTCATATGGGCAGCTGTGCTGAGAATACA
GCAAAGAAGCTGAATATTGCACGAAATGAACAGGACGCTTATGCTATTAATTCTTATACC
AGAAGTAAAGCAGCATGGGAAGCTGGGAAATTTGGAAATGAAGTTATTCCTGTCACAGTT
ACAGTAAAAGGTCAACCAGATGTAGTGGTGAAAGAAGATGAAGAATATAAACGTGTTGAT
TTTAGCAAAGTTCCAAAGCTGAAGACAGTTTTCCAGAAAGAAAATGGCACAGTAACAGCT
GCCAATGCCAGTACACTGAATGATGGAGCAGCTGCTCTGGTTCTCATGACGGCAGATGCA
GCGAAGAGGCTCAATGTTACACCACTGGCAAGAATAGTAGCATTTGCTGACGCTGCTGTA
GAACCTATTGATTTTCCAATTGCTCCTGTATATGCTGCATCTATGGTTCTTAAAGATGTG
GGATTGAAAAAAGAAGATATTGCAATGTGGGAAGTAAATGAAGCCTTTAGTCTGGTTGTA
CTAGCAAACATTAAAATGTTGGAGATTGATCCCCAAAAAGTGAATATCAATGGAGGAGCT
GTTTCTCTGGGACATCCAATTGGGATGTCTGGAGCCAGGATTGTTGGTCATTTGACTCAT
GCCTTGAAGCAAGGAGAATACGGTCTTGCCAGTATTTGCAATGGAGGAGGAGGTGCTTCT
GCCATGCTAATTCAGAAGCTGTAG

Protein Properties

Number of Residues

427

Molecular Weight

45199.2

Theoretical pI

8.846

Pfam Domain Function

Thiolase_C (PF02803 )
Thiolase_N (PF00108 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Acetyl-CoA acetyltransferase, mitochondrial
MAVLAALLRSGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRTPIGSFLGSLS
LLPATKLGSIAIQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPTRQAVLGAGLPISTPCT
TINKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMNRGSTPYGGVKLEDLIV
KDGLTDVYNKIHMGSCAENTAKKLNIARNEQDAYAINSYTRSKAAWEAGKFGNEVIPVTV
TVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAALVLMTADA
AKRLNVTPLARIVAFADAAVEPIDFPIAPVYAASMVLKDVGLKKEDIAMWEVNEAFSLVV
LANIKMLEIDPQKVNINGGAVSLGHPIGMSGARIVGHLTHALKQGEYGLASICNGGGGAS
AMLIQKL

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P24752

UniProtKB/Swiss-Prot Entry Name

THIL_HUMAN

PDB IDs