| Identification |
|---|
| HMDB Protein ID
| CDBP04653 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glycerol-3-phosphate acyltransferase 2, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- GPAT-2
- xGPAT1
|
| Gene Name
| GPAT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acyltransferase activity |
| Specific Function
| Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis (By similarity).
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| CDP-diacylglycerol biosynthetic process |
| phosphatidic acid biosynthetic process |
| glycerol-3-phosphate metabolic process |
| triglyceride biosynthetic process |
| Cellular Component |
| mitochondrial outer membrane |
| integral to membrane |
| Function |
| acyltransferase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| transferase activity, transferring acyl groups other than amino-acyl groups |
| Molecular Function |
| glycerol-3-phosphate O-acyltransferase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Multi-pass membrane protein
- Mitochondrion outer membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | CDP-diacylglycerol biosynthesis | Not Available | Not Available | | Glycerophospholipid metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q11.1 |
| SNPs
| GPAT2 |
| Gene Sequence
|
>2388 bp
ATGGCCACCATGTTGGAAGGCAGATGCCAAACTCAGCCAAGGAGCAGCCCCAGTGGCCGA
GAGGCTAGCCTGTGGTCGTCAGGCTTTGGGATGAAGCTGGAGGCTGTCACTCCATTCCTG
GGGAAGTATCGCCCCTTTGTGGGTCGCTGTTGCCAGACCTGCACCCCCAAGAGCTGGGAG
TCCCTCTTCCACAGAAGCATAACGGACCTAGGCTTCTGCAATGTGATCCTGGTGAAGGAG
GAGAACACAAGGTTTCGGGGCTGGCTGGTTCGGAGGCTCTGCTATTTCCTGTGGTCCCTG
GAGCAGCACATCCCCCCCTGCCAGGATGTCCCACAGAAGATCATGGAAAGCACCGGGGTG
CAGAACCTCCTCTCAGGGAGGGTCCCAGGAGGCACTGGGGAAGGCCAGGTGCCTGACCTT
GTGAAGAAGGAGGTACAGCGCATCCTGGGTCACATCCAGGCCCCACCCCGTCCCTTCCTG
GTCAGGCTGTTCAGCTGGGCGCTGCTGAGGTTCCTGAACTGCCTGTTCCTGAATGTGCAG
CTCCACAAGGGTCAGATGAAGATGGTCCAGAAGGCCGCCCAGGCAGGCTTGCCGCTTGTC
CTCCTCTCTACTCACAAAACCCTCCTGGATGGGATCCTGCTGCCCTTTATGCTGCTCTCC
CAGGGCCTGGGTGTGCTTCGTGTGGCCTGGGACTCCCGCGCCTGCTCCCCTGCCCTCAGA
GCTCTGCTGAGGAAGCTTGGGGGGCTTTTCCTGCCCCCAGAGGCCAGCCTCTCCCTGGAC
AGCTCTGAGGGGCTCCTTGCCAGGGCTGTGGTCCAGGCGGTCATAGAGCAGCTGCTGGTT
AGTGGGCAGCCCCTGCTCATCTTCCTGGAGGAACCTCCTGGGGCTCTGGGGCCACGGCTG
TCAGCCCTGGGCCAGGCTTGGGTGGGGTTTGTGGTGCAGGCAGTCCAGGTGGGCATCGTC
CCAGATGCTCTGCTGGTACCAGTGGCCGTCACCTATGACCTGGTTCCGGATGCACCGTGT
GACATAGACCATGCCTCGGCCCCCCTGGGGCTGTGGACAGGAGCTCTGGCTGTCCTACGT
AGCTTGTGGAGCCGCTGGGGCTGCAGCCACCGGATCTGCTCCCGGGTGCACCTAGCTCAG
CCCTTTTCCCTGCAGGAATACATCGTCAGTGCCAGAAGCTGCTGGGGCGGCAGACAGACC
CTGGAGCAGCTACTGCAGCCCATCGTGCTGGGCCAATGTACTGCTGTCCCAGACACTGAG
AAGGAGCAGGAGTGGACCCCCATAACTGGGCCTCTCCTGGCCCTCAAGGAAGAGGACCAG
CTCCTGGTCAGGAGACTGAGCTGTCATGTCCTGAGTGCCAGTGTAGGGAGCTCTGCGGTG
ATGAGCACGGCCATTATGGCAACGCTGCTGCTCTTCAAGCATCAGAAGCTCCTGGGGGAG
TTCTCCTGGCTGACGGAGGAGATACTGTTGCGTGGCTTTGATGTAGGCTTCTCTGGGCAG
CTGCGGAGCCTGCTGCAGCACTCACTGAGCCTGCTGCGGGCGCACGTGGCCCTGCTGCGC
ATCCGTCAGGGTGACTTGCTGGTGGTGCCGCAGCCTGGCCCAGGCCTCACACACCTGGCA
CAACTGAGTGCTGAGCTGCTGCCCGTCTTCCTGAGCGAGGCTGTGGGCGCCTGTGCAGTG
CGGGGGCTGCTGGCAGGCAGAGTGCCGCCCCAGGGGCCCTGGGAGCTGCAGGGCATATTG
CTGCTGAGCCAGAATGAGCTGTACCGCCAGATCCTGCTGCTGATGCACCTGCTGCCGCAA
GACCTGCTGCTGCTAAAGCCCTGCCAGTCTTCCTACTGCTACTGTCAGGAGGTGCTGGAC
CGGCTCATCCAATGCGGGCTCCTGGTTGCTGAGGAGACCCCAGGCTCCCGGCCAGCCTGT
GACACAGGGCGACAGCGATTGAGCAGAAAGCTGCTGTGGAAACCGAGTGGGGACTTTACT
GATAGTGACAGTGATGACTTCGGAGAGGCTGACGGCCGGTACTTCAGGCTCAGCCAGCAG
TCACACTGCCCAGATTTCTTTCTTTTCCTCTGCCGCCTGCTCAGCCCGCTGCTCAAGGCC
TTTGCACAGGCTGCCGCCTTCCTCCGCCAGGGCCAGCTGCCCGATACTGAGTTGGGCTAC
ACAGAGCAGCTGTTCCAGTTCCTGCAGGCCACCGCCCAGGAAGAAGGGATCTTCGAGTGT
GCGGACCCAAAGCTCGCCATCAGTGCTGTCTGGACCTTCAGAGACCTAGGGGTTCTGCAG
CAGACGCCGAGCCCTGCAGGCCCCAGGCTCCACCTGTCCCCTACTTTTGCCAGCCTGGAC
AATCAGGAAAAACTAGAACAGTTCATCCGGCAGTTCATTTGTAGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 795 |
| Molecular Weight
| 87834.5 |
| Theoretical pI
| 7.602 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glycerol-3-phosphate acyltransferase 2, mitochondrial
MATMLEGRCQTQPRSSPSGREASLWSSGFGMKLEAVTPFLGKYRPFVGRCCQTCTPKSWE
SLFHRSITDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPPCQDVPQKIMESTGV
QNLLSGRVPGGTGEGQVPDLVKKEVQRILGHIQAPPRPFLVRLFSWALLRFLNCLFLNVQ
LHKGQMKMVQKAAQAGLPLVLLSTHKTLLDGILLPFMLLSQGLGVLRVAWDSRACSPALR
ALLRKLGGLFLPPEASLSLDSSEGLLARAVVQAVIEQLLVSGQPLLIFLEEPPGALGPRL
SALGQAWVGFVVQAVQVGIVPDALLVPVAVTYDLVPDAPCDIDHASAPLGLWTGALAVLR
SLWSRWGCSHRICSRVHLAQPFSLQEYIVSARSCWGGRQTLEQLLQPIVLGQCTAVPDTE
KEQEWTPITGPLLALKEEDQLLVRRLSCHVLSASVGSSAVMSTAIMATLLLFKHQKLLGE
FSWLTEEILLRGFDVGFSGQLRSLLQHSLSLLRAHVALLRIRQGDLLVVPQPGPGLTHLA
QLSAELLPVFLSEAVGACAVRGLLAGRVPPQGPWELQGILLLSQNELYRQILLLMHLLPQ
DLLLLKPCQSSYCYCQEVLDRLIQCGLLVAEETPGSRPACDTGRQRLSRKLLWKPSGDFT
DSDSDDFGEADGRYFRLSQQSHCPDFFLFLCRLLSPLLKAFAQAAAFLRQGQLPDTELGY
TEQLFQFLQATAQEEGIFECADPKLAISAVWTFRDLGVLQQTPSPAGPRLHLSPTFASLD
NQEKLEQFIRQFICS
|
| External Links |
|---|
| GenBank ID Protein
| 116812614 |
| UniProtKB/Swiss-Prot ID
| Q6NUI2 |
| UniProtKB/Swiss-Prot Entry Name
| GPAT2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_207328.2 |
| GeneCard ID
| GPAT2 |
| GenAtlas ID
| GPAT2 |
| HGNC ID
| HGNC:27168 |
| References |
|---|
| General References
| Not Available |