| Identification |
|---|
| HMDB Protein ID
| CDBP02518 |
| Secondary Accession Numbers
| Not Available |
| Name
| Acyl-CoA wax alcohol acyltransferase 2 |
| Description
| Not Available |
| Synonyms
|
- Diacylglycerol O-acyltransferase 2-like protein 4
- Diacylglycerol O-acyltransferase candidate 4
- Long-chain-alcohol O-fatty-acyltransferase 2
- Multifunctional O-acyltransferase
- Wax synthase
- hDC4
- hWS
- Acyl-CoA retinol O-fatty-acyltransferase
- ARAT
- Retinol O-fatty-acyltransferase
|
| Gene Name
| AWAT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transferase activity, transferring acyl groups other than amino-acyl groups |
| Specific Function
| Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl-CoA:retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo.
|
| GO Classification
|
| Biological Process |
| wax biosynthetic process |
| Cellular Component |
| integral to membrane |
| endoplasmic reticulum membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| transferase activity, transferring acyl groups other than amino-acyl groups |
| Molecular Function |
| long-chain-alcohol O-fatty-acyltransferase activity |
| retinol O-fatty-acyltransferase activity |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Vitamin digestion and absorption | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Xq13.1 |
| SNPs
| AWAT2 |
| Gene Sequence
|
>1002 bp
ATGCTCTTGCCCTCTAAGAAGGACCTCAAGACTGCCCTGGATGTCTTTGCTGTTTTCCAG
TGGTCCTTCAGTGCCTTGCTTATCACAACCACTGTGATTGCTGTCAACCTCTACCTGGTG
GTGTTCACACCATACTGGCCTGTCACTGTGCTTATTCTTACCTGGCTGGCTTTTGACTGG
AAGACCCCTCAGCGAGGCGGCCGCCGGTTTACCTGTGTGAGGCACTGGCGCCTGTGGAAA
CACTACAGCGATTATTTCCCTCTCAAGCTTCTGAAGACTCATGACATCTGCCCCAGCCGC
AACTACATCCTCGTCTGCCACCCTCATGGGCTCTTTGCCCATGGATGGTTTGGCCACTTT
GCCACAGAGGCCTCAGGCTTCTCCAAGATATTTCCTGGCATCACCCCTTACATACTCACA
CTGGGAGCCTTTTTCTGGATGCCTTTCCTCAGAGAATATGTAATGTCTACAGGGGCCTGC
TCTGTGAGTCGATCCTCCATTGACTTTCTGCTGACTCATAAAGGCACAGGCAACATGGTC
ATTGTGGTGATTGGTGGACTGGCTGAGTGCAGATACAGCCTGCCAGGTTCTTCTACCCTG
GTGTTGAAGAACCGGTCTGGCTTTGTGCGCATGGCCCTTCAGCATGGGGTGCCTCTAATA
CCTGCCTATGCCTTTGGGGAGACGGACCTCTATGATCAGCACATTTTCACTCCTGGTGGC
TTTGTCAACCGCTTCCAGAAGTGGTTCCAGAGCATGGTACACATCTACCCTTGTGCTTTC
TATGGACGTGGCTTCACCAAGAACTCCTGGGGCCTTCTGCCCTATAGTCGGCCTGTAACC
ACCATCGTCGGGGAGCCTCTACCAATGCCCAAGATTGAGAATCCAAGCCAGGAGATCGTG
GCTAAATATCACACACTCTATATTGATGCCCTACGTAAACTGTTTGACCAGCATAAGACC
AAGTTTGGTATCTCAGAGACCCAGGAGCTGGAGATAATTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 333 |
| Molecular Weight
| 38093.25 |
| Theoretical pI
| 9.343 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Acyl-CoA wax alcohol acyltransferase 2
MLLPSKKDLKTALDVFAVFQWSFSALLITTTVIAVNLYLVVFTPYWPVTVLILTWLAFDW
KTPQRGGRRFTCVRHWRLWKHYSDYFPLKLLKTHDICPSRNYILVCHPHGLFAHGWFGHF
ATEASGFSKIFPGITPYILTLGAFFWMPFLREYVMSTGACSVSRSSIDFLLTHKGTGNMV
IVVIGGLAECRYSLPGSSTLVLKNRSGFVRMALQHGVPLIPAYAFGETDLYDQHIFTPGG
FVNRFQKWFQSMVHIYPCAFYGRGFTKNSWGLLPYSRPVTTIVGEPLPMPKIENPSQEIV
AKYHTLYIDALRKLFDQHKTKFGISETQELEII
|
| External Links |
|---|
| GenBank ID Protein
| 49854214 |
| UniProtKB/Swiss-Prot ID
| Q6E213 |
| UniProtKB/Swiss-Prot Entry Name
| AWAT2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY605053 |
| GeneCard ID
| AWAT2 |
| GenAtlas ID
| AWAT2 |
| HGNC ID
| HGNC:23251 |
| References |
|---|
| General References
| Not Available |