| Identification |
|---|
| HMDB Protein ID
| CDBP02420 |
| Secondary Accession Numbers
| Not Available |
| Name
| Diacylglycerol O-acyltransferase 2 |
| Description
| Not Available |
| Synonyms
|
- Diglyceride acyltransferase 2
- Acyl-CoA retinol O-fatty-acyltransferase
- ARAT
- Retinol O-fatty-acyltransferase
|
| Gene Name
| DGAT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transferase activity, transferring acyl groups other than amino-acyl groups |
| Specific Function
| Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).
|
| GO Classification
|
| Biological Process |
| low-density lipoprotein particle clearance |
| cholesterol homeostasis |
| triglyceride biosynthetic process |
| small molecule metabolic process |
| glycerol metabolic process |
| lipid storage |
| cellular response to oleic acid |
| long-chain fatty-acyl-CoA metabolic process |
| fatty acid homeostasis |
| acylglycerol acyl-chain remodeling |
| diacylglycerol metabolic process |
| glycerophospholipid biosynthetic process |
| cellular triglyceride homeostasis |
| fat pad development |
| Cellular Component |
| mitochondrion |
| integral to endoplasmic reticulum membrane |
| perinuclear region of cytoplasm |
| lipid particle |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| transferase activity, transferring acyl groups other than amino-acyl groups |
| Molecular Function |
| protein homodimerization activity |
| 2-acylglycerol O-acyltransferase activity |
| diacylglycerol O-acyltransferase activity |
| retinol O-fatty-acyltransferase activity |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | triacylglycerol biosynthesis | Not Available | Not Available | | Fat digestion and absorption | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q13.5 |
| SNPs
| DGAT2 |
| Gene Sequence
|
>1167 bp
ATGAAGACCCTCATAGCCGCCTACTCCGGGGTCCTGCGCGGCGAGCGTCAGGCCGAGGCT
GACCGGAGCCAGCGCTCTCACGGAGGACCTGCGCTGTCGCGCGAGGGGTCTGGGAGATGG
GGCACTGGATCCAGCATCCTCTCCGCCCTCCAGGACCTCTTCTCTGTCACCTGGCTCAAT
AGGTCCAAGGTGGAAAAGCAGCTACAGGTCATCTCAGTGCTCCAGTGGGTCCTGTCCTTC
CTTGTACTGGGAGTGGCCTGCAGTGCCATCCTCATGTACATATTCTGCACTGATTGCTGG
CTCATCGCTGTGCTCTACTTCACTTGGCTGGTGTTTGACTGGAACACACCCAAGAAAGGT
GGCAGGAGGTCACAGTGGGTCCGAAACTGGGCTGTGTGGCGCTACTTTCGAGACTACTTT
CCCATCCAGCTGGTGAAGACACACAACCTGCTGACCACCAGGAACTATATCTTTGGATAC
CACCCCCATGGTATCATGGGCCTGGGTGCCTTCTGCAACTTCAGCACAGAGGCCACAGAA
GTGAGCAAGAAGTTCCCAGGCATACGGCCTTACCTGGCTACACTGGCAGGCAACTTCCGA
ATGCCTGTGTTGAGGGAGTACCTGATGTCTGGAGGTATCTGCCCTGTCAGCCGGGACACC
ATAGACTATTTGCTTTCAAAGAATGGGAGTGGCAATGCTATCATCATCGTGGTCGGGGGT
GCGGCTGAGTCTCTGAGCTCCATGCCTGGCAAGAATGCAGTCACCCTGCGGAACCGCAAG
GGCTTTGTGAAACTGGCCCTGCGTCATGGAGCTGACCTGGTTCCCATCTACTCCTTTGGA
GAGAATGAAGTGTACAAGCAGGTGATCTTCGAGGAGGGCTCCTGGGGCCGATGGGTCCAG
AAGAAGTTCCAGAAATACATTGGTTTCGCCCCATGCATCTTCCATGGTCGAGGCCTCTTC
TCCTCCGACACCTGGGGGCTGGTGCCCTACTCCAAGCCCATCACCACTGTTGTGGGAGAG
CCCATCACCATCCCCAAGCTGGAGCACCCAACCCAGCAAGACATCGACCTGTACCACACC
ATGTACATGGAGGCCCTGGTGAAGCTCTTCGACAAGCACAAGACCAAGTTCGGCCTCCCG
GAGACTGAGGTCCTGGAGGTGAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 388 |
| Molecular Weight
| 39043.88 |
| Theoretical pI
| 9.362 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Diacylglycerol O-acyltransferase 2
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
|
| External Links |
|---|
| GenBank ID Protein
| 22506631 |
| UniProtKB/Swiss-Prot ID
| Q96PD7 |
| UniProtKB/Swiss-Prot Entry Name
| DGAT2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB048286 |
| GeneCard ID
| DGAT2 |
| GenAtlas ID
| DGAT2 |
| HGNC ID
| HGNC:16940 |
| References |
|---|
| General References
| Not Available |