| Identification |
|---|
| HMDB Protein ID
| CDBP02588 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glycine N-acyltransferase |
| Description
| Not Available |
| Synonyms
|
- AAc
- Acyl-CoA:glycine N-acyltransferase
- Aralkyl acyl-CoA N-acyltransferase
- Aralkyl acyl-CoA:amino acid N-acyltransferase
- HRP-1(CLP)
- Benzoyl-coenzyme A:glycine N-acyltransferase
- Glycine N-benzoyltransferase
|
| Gene Name
| GLYAT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glycine N-acyltransferase activity |
| Specific Function
| Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.
|
| GO Classification
|
| Biological Process |
| acyl-CoA metabolic process |
| glycine metabolic process |
| monocarboxylic acid metabolic process |
| xenobiotic metabolic process |
| response to toxin |
| Cellular Component |
| mitochondrial matrix |
| Component |
| mitochondrion |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| Function |
| transferase activity, transferring acyl groups other than amino-acyl groups |
| acyltransferase activity |
| n-acyltransferase activity |
| glycine n-acyltransferase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| Molecular Function |
| glycine N-acyltransferase activity |
| glycine N-benzoyltransferase activity |
|
| Cellular Location
|
- Mitochondrion
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Phenylacetate Metabolism |    |  | | Phenylalanine metabolism | Not Available | |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q12.1 |
| SNPs
| GLYAT |
| Gene Sequence
|
>891 bp
ATGATGTTACCATTGCAAGGTGCCCAGATGCTGCAGATGCTGGAGAAATCCTTGAGGAAG
AGCCTCCCAGCATCCTTAAAGGTTTATGGAACTGTCTTTCACATAAACCATGGAAATCCA
TTCAATCTGAAGGCTGTGGTGGACAAGTGGCCTGATTTTAATACAGTGGTTGTCTGCCCT
CAGGAGCAGGATATGACAGATGACCTTGATCACTATACCAATACTTACCAAATCTACTCC
AAAGATCCCCAAAACTGTCAGGAATTCCTTGGATCACCAGAACTCATCAACTGGAAACAG
CATTTACAGATTCAAAGTTCACAGCCTAGCCTGAATGAGGCTATACAAAATCTTGCAGCC
ATTAAGTCCTTCAAAGTCAAACAAACACAACGCATTCTCTATATGGCAGCTGAAACAGCC
AAGGAACTGACTCCTTTCCTGCTGAAATCAAAGATTTTATCTCCCAATGGTGGCAAACCC
AAGGCCATCAACCAAGAGATGTTTAAACTCTCATCCATGGATGTTACCCATGCTCACTTG
GTGAATAAATTCTGGCATTTTGGTGGTAATGAGAGGAGCCAGAGATTCATTGAGCGCTGC
ATTCAGACCTTTCCCACCTGCTGTCTCCTGGGGCCTGAGGGGACCCCTGTGTGCTGGGAT
CTAATGGACCAGACTGGAGAGATGAGAATGGCAGGCACCTTGCCGGAATACCGGCTCCAT
GGCCTTGTGACGTATGTCATCTATTCCCACGCCCAGAAATTGGGCAAACTTGGGTTTCCT
GTCTATTCTCATGTAGACTACAGCAATGAAGCTATGCAAAAAATGAGTTACACACTGCAA
CATGTTCCCATTCCCAGAAGCTGGAACCAGTGGAACTGTGTACCTCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 296 |
| Molecular Weight
| 18506.33 |
| Theoretical pI
| 8.703 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glycine N-acyltransferase
MMLPLQGAQMLQMLEKSLRKSLPASLKVYGTVFHINHGNPFNLKAVVDKWPDFNTVVVCP
QEQDMTDDLDHYTNTYQIYSKDPQNCQEFLGSPELINWKQHLQIQSSQPSLNEAIQNLAA
IKSFKVKQTQRILYMAAETAKELTPFLLKSKILSPSGGKPKAINQEMFKLSSMDVTHAHL
VNKFWHFGGNERSQRFIERCIQTFPTCCLLGPEGTPVCWDLMDQTGEMRMAGTLPEYRLH
GLVTYVIYSHAQKLGKLGFPVYSHVDYSNEAMQKMSYTLQHVPIPRSWNQWNCVPL
|
| External Links |
|---|
| GenBank ID Protein
| 111038137 |
| UniProtKB/Swiss-Prot ID
| Q6IB77 |
| UniProtKB/Swiss-Prot Entry Name
| GLYAT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_201648.2 |
| GeneCard ID
| GLYAT |
| GenAtlas ID
| GLYAT |
| HGNC ID
| HGNC:13734 |
| References |
|---|
| General References
| Not Available |