| Identification |
|---|
| HMDB Protein ID
| CDBP01908 |
| Secondary Accession Numbers
| Not Available |
| Name
| Acyl-CoA-binding protein |
| Description
| Not Available |
| Synonyms
|
- ACBP
- DBI
- Diazepam-binding inhibitor
- EP
- Endozepine
|
| Gene Name
| DBI |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acyl-CoA binding |
| Specific Function
| Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor |
| GO Classification
|
| Function |
| acyl-coa binding |
| lipid binding |
| binding |
| fatty acid binding |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q12-q21 |
| SNPs
| DBI |
| Gene Sequence
|
>252 bp
GCTGAGTTTGAGAAAGCTGCAGAGGAGGTTAGGCACCTTAAGACCAAGCCAGCAGATGAT
GAGATGCTGTTCATCTATGGCCGCTACAAACAAGCAACTGTGGGCGACATAAATACAGAA
CGGCCCGGGATGTTGGACTTCACAGGCAAGGCCAAGTGGGATGCCTGGAATGAGCTGAAA
GGGACTACCAAGGAAGATGCCATGAAAGCTTACATCAACAAAGTAGAAGAGCTAAAGAAA
AAATACGGGATA
|
| Protein Properties |
|---|
| Number of Residues
| 87 |
| Molecular Weight
| 10044.4 |
| Theoretical pI
| 6.54 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Acyl-CoA-binding protein
MSQAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWN
ELKGTSKEDAMKAYINKVEELKKKYGI
|
| External Links |
|---|
| GenBank ID Protein
| 73746603 |
| UniProtKB/Swiss-Prot ID
| P07108 |
| UniProtKB/Swiss-Prot Entry Name
| ACBP_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| DQ150443 |
| GeneCard ID
| DBI |
| GenAtlas ID
| DBI |
| HGNC ID
| HGNC:2690 |
| References |
|---|
| General References
| Not Available |