| Identification |
|---|
| HMDB Protein ID
| CDBP05134 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histone acetyltransferase KAT7 |
| Description
| Not Available |
| Synonyms
|
- Histone acetyltransferase binding to ORC1
- MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
- MYST-2
- Lysine acetyltransferase 7
|
| Gene Name
| KAT7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transferase activity, transferring acyl groups other than amino-acyl groups |
| Specific Function
| Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.
|
| GO Classification
|
| Biological Process |
| DNA replication |
| histone H3 acetylation |
| regulation of transcription, DNA-dependent |
| transcription, DNA-dependent |
| histone H4-K12 acetylation |
| histone H4-K5 acetylation |
| histone H4-K8 acetylation |
| Cellular Component |
| histone acetyltransferase complex |
| Component |
| cell part |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| intracellular |
| Function |
| sequence-specific dna binding transcription factor activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transition metal ion binding |
| zinc ion binding |
| transferase activity |
| transferase activity, transferring acyl groups |
| transferase activity, transferring acyl groups other than amino-acyl groups |
| Molecular Function |
| metal ion binding |
| sequence-specific DNA binding transcription factor activity |
| zinc ion binding |
| histone acetyltransferase activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
|
| Cellular Location
|
- Nucleus
- nucleoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q21.32 |
| SNPs
| MYST2 |
| Gene Sequence
|
>1836 bp
ATGCCGCGAAGGAAGAGGAATGCAGGCAGTAGTTCAGATGGAACCGAAGATTCCGATTTT
TCTACAGATCTCGAGCACACAGACAGTTCAGAAAGTGATGGCACATCCCGACGATCTGCT
CGAGTCACCCGCTCCTCAGCCAGGCTAAGCCAGAGTTCTCAAGATTCCAGTCCTGTTCGA
AATCTGCAGTCTTTTGGCACTGAGGAGCCTGCTTACTCTACCAGAAGAGTGACCCGTAGT
CAGCAGCAGCCTACCCCAGTGACACCGAAAAAATACCCTCTTCGGCAGACTCGTTCATCT
GGTTCAGAAACTGAGCAAGTGGTTGATTTTTCAGATAGAGAAACTAAAAATACAGCTGAT
CATGATGAGTCACCGCCTCGAACTCCAACTGGAAATGCGCCTTCTTCTGAGTCTGACATA
GATATCTCCAGCCCCAATGTATCTCACGATGAGAGCATTGCCAAGGACATGTCCCTGAAG
GACTCAGGCAGTGATCTCTCTCATCGCCCCAAGCGCCGTCGCTTCCATGAAAGCTACAAC
TTCAATATGAAGTGTCCTACACCAGGCTGTAACTCTCTAGGACACCTTACAGGAAAACAT
GAGAGACATTTCTCCATCTCAGGATGCCCACTGTATCATAACCTCTCAGCTGACGAATGC
AAGGTGAGAGCACAGAGCCGGGATAAGCAGATAGAAGAAAGGATGCTGTCTCACAGGCAA
GATGACAACAACAGGCATGCAACCAGGCACCAGGCACCAACGGAGAGGCAGCTTCGATAT
AAGGAAAAAGTGGCTGAACTCAGGAAGAAAAGAAATTCTGGACTGAGCAAAGAACAGAAA
GAGAAATATATGGAACACAGACAGACCTATGGGAACACACGGGAACCTCTTTTAGAAAAC
CTGACAAGCGAGTATGACTTGGATCTTTTCCGAAGAGCACAAGCCCGGGCTTCAGAGGAT
TTGGAGAAGTTAAGGCTGCAAGGCCAAATCACAGAGGGAAGCAACATGATTAAAACAATT
GCTTTTGGCCGCTATGAGCTTGATACCTGGTATCATTCTCCATATCCTGAAGAATATGCA
CGGCTGGGACGTCTCTATATGTGTGAATTCTGTTTAAAATATATGAAGAGCCAAACGATA
CTCCGCCGGCACATGGCCAAATGTGTGTGGAAACACCCACCTGGTGATGAGATATATCGC
AAAGGTTCAATCTCTGTGTTTGAAGTGGATGGCAAGAAAAACAAGATCTACTGCCAAAAC
CTGTGCCTGTTGGCCAAACTTTTTCTGGACCACAAGACATTATATTATGATGTGGAGCCC
TTCCTGTTCTATGTTATGACAGAGGCGGACAACACTGGCTGTCACCTGATTGGATATTTT
TCTAAGGAAAAGAATTCATTCCTCAACTACAACGTCTCCTGTATCCTTACTATGCCTCAG
TACATGAGACAGGGCTATGGCAAGATGCTTATTGATTTCAGTTATTTGCTTTCCAAAGTC
GAAGAAAAAGTTGGCTCCCCAGAACGTCCACTCTCAGATCTGGGGCTTATAAGCTATCGC
AGTTACTGGAAAGAAGTACTTCTCCGCTACCTGCATAATTTTCAAGGCAAAGAGATTTCT
ATCAAAGAAATCAGTCAGGAGACGGCTGTGAATCCTGTGGACATTGTCAGCACTCTGCAA
GCCCTTCAGATGCTCAAATACTGGAAGGGAAAACACCTAGTTTTAAAGAGACAGGACCTG
ATTGATGAGTGGATAGCCAAAGAGGCCAAAAGGTCCAACTCCAATAAAACCATGGATCCC
AGCTGCTTAAAATGGACCCCTCCCAAGGGCACTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 611 |
| Molecular Weight
| 66946.78 |
| Theoretical pI
| 8.724 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histone acetyltransferase MYST2
MPRRKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTRSSARLSQSSQDSSPVR
NLQSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQVVDFSDRETKNTAD
HDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKDSGSDLSHRPKRRRFHESYN
FNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSHRQ
DDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLEN
LTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYA
RLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQN
LCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQ
YMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEIS
IKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDP
SCLKWTPPKGT
|
| External Links |
|---|
| GenBank ID Protein
| 4091980 |
| UniProtKB/Swiss-Prot ID
| O95251 |
| UniProtKB/Swiss-Prot Entry Name
| MYST2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF074606 |
| GeneCard ID
| MYST2 |
| GenAtlas ID
| MYST2 |
| HGNC ID
| HGNC:17016 |
| References |
|---|
| General References
| Not Available |