Cannabis Compound Database: Showing Compound Card for Uridine 5'-diphosphate (CDB005147)

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Record Information

Version

1.0

Created at

2020-04-17 19:14:04 UTC

Updated at

2020-11-18 16:39:26 UTC

CannabisDB ID

CDB005147

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Uridine 5'-diphosphate

Description

Uridine 5'-diphosphate, also known as 5'-UDP or uridine diphosphoric acid, belongs to the class of organic compounds known as pyrimidine ribonucleoside diphosphates. These are pyrimidine ribonucleotides with diphosphate group linked to the ribose moiety. Uridine 5'-diphosphate is an important extracellular pyrimidine signaling molecule that mediates diverse biological effects via P1 and P2 purinergic receptors, such as the uptake of thymidine and proliferation of gliomas. Uridine 5'-diphosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Uridine 5'-diphosphate exists in all living species, ranging from bacteria to humans. Within humans, uridine 5'-diphosphate participates in a number of enzymatic reactions. In particular, tamoxifen-N-glucuronide and uridine 5'-diphosphate can be biosynthesized from tamoxifen and uridine diphosphate glucuronic acid through the action of the enzyme UDP-glucuronosyltransferase 1-4. In addition, 4-hydroxytamoxifen-O-glucuronide and uridine 5'-diphosphate can be biosynthesized from 4-hydroxytamoxifen and uridine diphosphate glucuronic acid through the action of the enzyme UDP-glucuronosyltransferase 1-4. In humans, uridine 5'-diphosphate is involved in tamoxifen metabolism pathway. Outside of the human body, Uridine 5'-diphosphate has been detected, but not quantified in, several different foods, such as pineapples, pine nuts, potato, swiss chards, and lima beans. This could make uridine 5'-diphosphate a potential biomarker for the consumption of these foods. Uridine 5'-diphosphate induces intracellular Ca(2+) responses and oscillations in HeLa cells, due to the activation of P2Ys (G-protein coupled ATP receptors). Uridine 5'-diphosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Value	Source
Uridine diphosphate	ChEBI
Uridine diphosphoric acid	Generator
Uridine 5'-diphosphoric acid	Generator
5'-UDP	HMDB
UDP	HMDB
Uridine 5'-pyrophosphate	HMDB
Uridine 5'-pyrophosphorate	HMDB
Uridine 5'-pyrophosphoric acid	HMDB
Uridine pyrophosphate	HMDB
Pyrophosphate, uridine	HMDB
Diphosphate, uridine	HMDB
5’-UDP	HMDB
Uridine 5'-(trihydrogen pyrophosphate)	HMDB
Uridine 5'-diphosphate	HMDB
Uridine 5’-(trihydrogen pyrophosphate)	HMDB
Uridine 5’-diphosphate	HMDB
Uridine 5’-diphosphoric acid	HMDB
Uridine 5’-pyrophosphate	HMDB
Uridine 5’-pyrophosphoric acid	HMDB

Chemical Formula

C₉H₁₄N₂O₁₂P₂

Average Molecular Weight

404.16

Monoisotopic Molecular Weight

404.0022

IUPAC Name

[({[(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid

Traditional Name

UDP

CAS Registry Number

58-98-0

SMILES

O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O

InChI Identifier

InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

InChI Key

XCCTYIAWTASOJW-XVFCMESISA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pyrimidine ribonucleoside diphosphates. These are pyrimidine ribonucleotides with diphosphate group linked to the ribose moiety.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Pyrimidine nucleotides

Sub Class

Pyrimidine ribonucleotides

Direct Parent

Pyrimidine ribonucleoside diphosphates

Alternative Parents

Substituents

Pyrimidine ribonucleoside diphosphate
Pentose phosphate
Pentose-5-phosphate
Glycosyl compound
N-glycosyl compound
Monosaccharide phosphate
Organic pyrophosphate
Hydroxypyrimidine
Pyrimidone
Monoalkyl phosphate
Hydropyrimidine
Monosaccharide
Organic phosphoric acid derivative
Phosphoric acid ester
Pyrimidine
Alkyl phosphate
Heteroaromatic compound
Tetrahydrofuran
Secondary alcohol
1,2-diol
Oxacycle
Azacycle
Organoheterocyclic compound
Organic nitrogen compound
Hydrocarbon derivative
Organooxygen compound
Organonitrogen compound
Organic oxide
Alcohol
Organopnictogen compound
Organic oxygen compound
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

pyrimidine ribonucleoside 5'-diphosphate (CHEBI:17659 )
uridine 5'-phosphate (CHEBI:17659 )
Ribonucleotides (C00015 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Plant:

Animal

Biological location:

Organ and components:

Prostate

Endocrine gland:

Thyroid gland

Tissue and substructures:

Placenta

Biofluid and excreta:

Blood

Subcellular:

Cell and elements:

Extracellular

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.94	ALOGPS
logP	-3	ChemAxon
logS	-1.7	ALOGPS
pKa (Strongest Acidic)	1.77	ChemAxon
pKa (Strongest Basic)	-3.7	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	10	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	212.39 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	74.31 m³·mol⁻¹	ChemAxon
Polarizability	30.43 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	Uridine 5'-diphosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-004i-4911000000-e0e7874495a5b5baf6b1	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00pi-3795210000-ef08b4deabe40209df75	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_1_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_2_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_2_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_2_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_2_7, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_2_8, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_2_9, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_2_10, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TMS_2_11, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TBDMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TBDMS_1_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TBDMS_2_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Uridine 5'-diphosphate, TBDMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0002-9000000000-7c065a8df0e08b8c365f	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0002-9000000000-73234233232c376d095c	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0002-9000000000-7c065a8df0e08b8c365f	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-0pdi-6910600000-bf4136774851b6559f17	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-0pdi-6910600000-bf4136774851b6559f17	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - 30V, Negative	splash10-0bvi-3912100000-a85c42f0aa8800737e6c	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Negative	splash10-0bvi-5911000000-9cf722992950c6d4d813	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 30V, Negative	splash10-0bvi-3912100000-9a84dfae5b45e1758839	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 30V, Negative	splash10-0a6r-5911100000-836559f8456eab3c21f1	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9300000000-bccd47417032b18d3248	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-0udi-0000900000-36505fd7325e7a1183ed	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-0bvi-3923300000-00c8815d00c3062c179c	2021-09-20	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-03di-1901000000-4c9ba16543da8ee18c74	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03di-4901000000-1ff9973ec00da457d453	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03di-7900000000-f88f01d934d46a57fefb	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0ik9-3904300000-454bc02fb8862a1d0fac	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-057l-9801000000-5aabcad933dc7e5003a8	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9100000000-7a6d480c699f409f2f36	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0zfr-0301900000-5982e30a90f44090f97e	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-004i-9310100000-5890642f8c3624f36d55	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9100000000-7bb49a1f0cfcf1695e1e	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0bt9-0630900000-ff34650c58a8429ecb3c	2021-09-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03fr-2960000000-62a0e10267c1a3466957	2021-09-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03di-6900000000-7237951ebe305f184b3e	2021-09-25	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Lactose Synthesis		Not Available
Pyrimidine Metabolism
Amino Sugar Metabolism
Sialuria or French Type Sialuria		Not Available
Salla Disease/Infantile Sialic Acid Storage Disease		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
UMP-CMP kinase	CMPK1	1p32	P30085	details
Ectonucleoside triphosphate diphosphohydrolase 1	ENTPD1	10q24	P49961	details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Ectonucleoside triphosphate diphosphohydrolase 3	ENTPD3	3p21.3	O75355	details
Uridine-cytidine kinase 1	UCK1	9q34.13	Q9HA47	details
Nucleoside diphosphate kinase, mitochondrial	NME4	16p13.3	O00746	details
Ribonucleoside-diphosphate reductase large subunit	RRM1	11p15.5	P23921	details
Nucleoside diphosphate kinase A	NME1	17q21.3	P15531	details
Nucleoside diphosphate kinase 7	NME7	1q24	Q9Y5B8	details
Ribonucleoside-diphosphate reductase subunit M2	RRM2	2p25-p24	P31350	details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
Nucleoside diphosphate kinase 3	NME3	16q13.3	Q13232	details
Nucleoside diphosphate kinase 6	NME6	3p21	O75414	details
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	GNE	9p13.3	Q9Y223	details
Beta-1,4-galactosyltransferase 2	B4GALT2	1p34-p33	O60909	details
Alpha-lactalbumin	LALBA		P00709	details
Beta-1,4-galactosyltransferase 1	B4GALT1	9p13	P15291	details
UDP-glucuronosyltransferase 2B28	UGT2B28	4q13.2	Q9BY64	details
UDP-glucuronosyltransferase 2B4	UGT2B4	4q13	P06133	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	7q22	O60568	details
Chondroitin sulfate N-acetylgalactosaminyltransferase 1	CSGALNACT1	8p21.3	Q8TDX6	details
UDP-glucuronosyltransferase 1-4	UGT1A4	2q37	P22310	details
UDP-glucuronosyltransferase 2B10	UGT2B10	4q13.2	P36537	details
UDP-glucuronosyltransferase 2B7	UGT2B7	4q13	P16662	details
UDP-glucuronosyltransferase 2B15	UGT2B15	4q13	P54855	details
UDP-glucuronosyltransferase 2A1	UGT2A1	4q13.3	Q9Y4X1	details
UDP-glucuronosyltransferase 1-1	UGT1A1	2q37	P22309	details
UDP-glucuronosyltransferase 1-9	UGT1A9	2q37	O60656	details
UDP-glucuronosyltransferase 1-8	UGT1A8	2q37	Q9HAW9	details
UDP-glucuronosyltransferase 1-3	UGT1A3	2q37	P35503	details
UDP-glucuronosyltransferase 1-10	UGT1A10	2q37	Q9HAW8	details
UDP-glucuronosyltransferase 2B17	UGT2B17	4q13	O75795	details
UDP-glucuronosyltransferase 1-6	UGT1A6	2q37	P19224	details
UDP-glucuronosyltransferase 1-5	UGT1A5	2q37	P35504	details
UDP-glucuronosyltransferase 2B11	UGT2B11	4q13.2	O75310	details
UDP-glucuronosyltransferase 1-7	UGT1A7	2q37	Q9HAW7	details
GTP:AMP phosphotransferase, mitochondrial	AK3	9p24.1	Q9UIJ7	details
6-phosphofructokinase type C	PFKP	10p15.3-p15.2	Q01813	details
6-phosphofructokinase, liver type	PFKL	21q22.3	P17858	details
6-phosphofructokinase, muscle type	PFKM	12q13.3	P08237	details
Pyruvate kinase isozymes M1/M2	PKM	15q22	P14618	details
Pyruvate kinase isozymes R/L	PKLR	1q21	P30613	details
Ceramide glucosyltransferase	UGCG	9q31	Q16739	details
Beta-1,4 N-acetylgalactosaminyltransferase 1	B4GALNT1	12q13.3	Q00973	details
Lactosylceramide 4-alpha-galactosyltransferase	A4GALT	22q13.2	Q9NPC4	details
Ectonucleoside triphosphate diphosphohydrolase 4	ENTPD4	8p21.3	Q9Y227	details
Ectonucleoside triphosphate diphosphohydrolase 6	ENTPD6	20p11.21	O75354	details
Ectonucleoside triphosphate diphosphohydrolase 5	ENTPD5	14q24	O75356	details
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3	B3GAT3	11q12.3	O94766	details
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2	B3GAT2	6q13	Q9NPZ5	details
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1	B3GAT1	11q25	Q9P2W7	details
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q	PIGQ	16p13.3	Q9BRB3	details
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A	PIGA	Xp22.1	P37287	details
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H	PIGH	14q24.1	Q14442	details
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	PIGP	21q22.2	P57054	details
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C	PIGC	1q23-q25	Q92535	details
Dolichyl-phosphate beta-glucosyltransferase	ALG5	13q13.3	Q9Y673	details
Polypeptide N-acetylgalactosaminyltransferase 11	GALNT11	7q36.1	Q8NCW6	details
Polypeptide N-acetylgalactosaminyltransferase 4	GALNT4	12q21.33	Q8N4A0	details
Polypeptide N-acetylgalactosaminyltransferase 3	GALNT3	2q24-q31	Q14435	details
Probable polypeptide N-acetylgalactosaminyltransferase 8	GALNT8	12p13.3	Q9NY28	details
Polypeptide N-acetylgalactosaminyltransferase-like protein 2	GALNTL2	3p25.1	Q8N3T1	details
Putative polypeptide N-acetylgalactosaminyltransferase-like protein 1	GALNTL1	14q24.1	Q8N428	details
Polypeptide N-acetylgalactosaminyltransferase 10	GALNT10	5q33.2	Q86SR1	details
Polypeptide N-acetylgalactosaminyltransferase 13	GALNT13	2q24.1	Q8IUC8	details
Putative polypeptide N-acetylgalactosaminyltransferase-like protein 3	WBSCR17	7q11.23	Q6IS24	details
Putative polypeptide N-acetylgalactosaminyltransferase-like protein 4	GALNTL4	11p15.3	Q6P9A2	details
N-acetylgalactosaminyltransferase 7	GALNT7	4q31.1	Q86SF2	details
Polypeptide N-acetylgalactosaminyltransferase 6	GALNT6	12q13	Q8NCL4	details
Polypeptide N-acetylgalactosaminyltransferase 14	GALNT14	2p23.1	Q96FL9	details
Polypeptide N-acetylgalactosaminyltransferase 2	GALNT2	1q41-q42	Q10471	details
Polypeptide N-acetylgalactosaminyltransferase 12	GALNT12	9q22.33	Q8IXK2	details
Polypeptide N-acetylgalactosaminyltransferase 1	GALNT1	18q12.1	Q10472	details
Polypeptide N-acetylgalactosaminyltransferase 5	GALNT5	2q24.1	Q7Z7M9	details
Beta-1,4-galactosyltransferase 3	B4GALT3	1q21-q23	O60512	details
Beta-1,4-galactosyltransferase 4	B4GALT4	3q13.3	O60513	details
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1	B3GALNT1	3q25	O75752	details
Glycogen [starch] synthase, liver	GYS2	12p12.2	P54840	details
Glycogen [starch] synthase, muscle	GYS1	19q13.3	P13807	details
Histo-blood group ABO system transferase	ABO	9q34.2	P16442	details
2-hydroxyacylsphingosine 1-beta-galactosyltransferase	UGT8	4q26	Q16880	details
Beta-1,3-galactosyltransferase 4	B3GALT4	6p21.3	O96024	details
Chondroitin sulfate synthase 3	CHSY3	5q23.3	Q70JA7	details
Chondroitin sulfate synthase 2	CHPF	2q35	Q8IZ52	details
Chondroitin sulfate synthase 1	CHSY1	15q26.3	Q86X52	details
Polyribonucleotide nucleotidyltransferase 1, mitochondrial	PNPT1	2p15	Q8TCS8	details
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	MGAT2	14q21	Q10469	details
Exostosin-1	EXT1	8q24.11	Q16394	details
Hyaluronan synthase 1	HAS1	19q13.4	Q92839	details
Exostosin-like 3	EXTL3	8p21	O43909	details
Exostosin-2	EXT2	11p12-p11	Q93063	details
Exostosin-like 1	EXTL1	1p36.1	Q92935	details
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase	B3GNT1	11q13.2	O43505	details
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A	MGAT5	2q21.3	Q09328	details
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	OGT	Xq13	O15294	details
Hyaluronan synthase 3	HAS3	16q22.1	O00219	details
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	MGAT3	22q13.1	Q09327	details
Hyaluronan synthase 2	HAS2	8q24.12	Q92819	details
Uridine-cytidine kinase 2	UCK2	1q23	Q9BZX2	details
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform B	GCNT2	6p24.2	Q06430	details
Beta-1,4-galactosyltransferase 7	B4GALT7	5q35.2-q35.3	Q9UBV7	details
Chondroitin sulfate glucuronyltransferase	CHPF2	7q36.1	Q9P2E5	details
Chondroitin sulfate N-acetylgalactosaminyltransferase 2	CSGALNACT2	10q11.21	Q8N6G5	details
ENTPD4 protein	ENTPD4	8p21.3	Q8NE73	details
Beta-1,3-N-acetylglucosaminyltransferase bGnT-2	bGnT-2	2p15	Q9NY97	details
Beta-1,3-galactosyltransferase 6	B3GALT6	1p36.33	Q96L58	details
Polypeptide N-acetylgalactosaminyltransferase 9	GALNT9	12q24.33	Q9HCQ5	details
Exostosin-like 2	EXTL2	1p21	Q9UBQ6	details
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A	MGAT4A	2q12	Q9UM21	details
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B	MGAT4B	5q35	Q9UQ53	details
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase	B3GNT5	3q28	Q9BYG0	details
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	C1GALT1	7p21.3	Q9NS00	details
Beta-1,4-galactosyltransferase 6	B4GALT6	18q11	Q9UBX8	details
UDP-glucuronosyltransferase 2A3	UGT2A3	4q13.2	Q6UWM9	details
Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	8q23.1	Q7LG56	details
UMP-CMP kinase 2, mitochondrial	CMPK2	2p25.2	Q5EBM0	details
Uridine-cytidine kinase-like 1	UCKL1	20q13.33	Q9NWZ5	details
Ectonucleoside triphosphate diphosphohydrolase 8	ENTPD8	9q34.3	Q5MY95	details
Polypeptide N-acetylgalactosaminyltransferase-like 6	GALNTL6	4q34.1	Q49A17	details
Putative polypeptide N-acetylgalactosaminyltransferase-like protein 5	GALNTL5	7q36.1	Q7Z4T8	details
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1	POMGNT1	1p34.1	Q8WZA1	details
Beta-1,4-N-acetylgalactosaminyltransferase 3	B4GALNT3	12p13.33	Q6L9W6	details
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1	B4GALNT4	11p15.5	Q76KP1	details
HCG2039726, isoform CRA_f	UGT1A10	2q37	Q5DT02	details
HCG2039726, isoform CRA_e	UGT1A8	2q37	Q5DSZ6	details
UDP glycosyltransferase 1 family polypeptide A7	UGT1A7	2q37	Q5DSZ7	details
Pp-GalNAc-transferase 20	GALNT20		Q2L4S5	details
UDP-N-acetylglucosamine transferase subunit ALG13 homolog	ALG13	Xq23	Q9NP73	details
EGF domain-specific O-linked N-acetylglucosamine transferase	EOGT	3p14.1	Q5NDL2	details
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase	GCNT1	9q13	Q02742	details
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3	GCNT3	15q21.3	O95395	details
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4	GCNT4	5q12	Q9P109	details
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A	GCNT2	6p24.2	Q8N0V5	details
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C	GCNT2	6p24.2	Q8NFS9	details
Procollagen galactosyltransferase 1	GLT25D1	19p13.11	Q8NBJ5	details
Procollagen galactosyltransferase 2	GLT25D2	1q25	Q8IYK4	details
Glycosyltransferase-like domain-containing protein 2	GTDC2	3p22.1	Q8NAT1	details
Glucoside xylosyltransferase 1	GXYLT1	12q12	Q4G148	details
Glucoside xylosyltransferase 2	GXYLT2	3p13	A0PJZ3	details
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	MGAT1	5q35	P26572	details
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C	MGAT4C	12q21	Q9UBM8	details
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B	MGAT5B	17q25.2	Q3V5L5	details
Nucleoside diphosphate kinase homolog 5	NME5		P56597	details
UDP-glucuronosyltransferase 3A1	UGT3A1	5p13.2	Q6NUS8	details
UDP-glucuronosyltransferase 3A2	UGT3A2	5p13.2	Q3SY77	details
Xyloside xylosyltransferase 1	XXYLT1	3q29	Q8NBI6	details

Transporters

Not Available

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Nucleoside diphosphate kinase, mitochondrial	NME4	16p13.3	O00746	details
Nucleoside diphosphate kinase 7	NME7	1q24	Q9Y5B8	details
Ribonucleoside-diphosphate reductase subunit M2	RRM2	2p25-p24	P31350	details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
Nucleoside diphosphate kinase 3	NME3	16q13.3	Q13232	details
Nucleoside diphosphate kinase 6	NME6	3p21	O75414	details
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	GNE	9p13.3	Q9Y223	details
Beta-1,4-galactosyltransferase 2	B4GALT2	1p34-p33	O60909	details
Alpha-lactalbumin	LALBA		P00709	details
Beta-1,4-galactosyltransferase 1	B4GALT1	9p13	P15291	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	7q22	O60568	details
Chondroitin sulfate N-acetylgalactosaminyltransferase 1	CSGALNACT1	8p21.3	Q8TDX6	details
6-phosphofructokinase type C	PFKP	10p15.3-p15.2	Q01813	details
6-phosphofructokinase, liver type	PFKL	21q22.3	P17858	details
6-phosphofructokinase, muscle type	PFKM	12q13.3	P08237	details
Pyruvate kinase isozymes M1/M2	PKM	15q22	P14618	details
Pyruvate kinase isozymes R/L	PKLR	1q21	P30613	details
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2	B3GAT2	6q13	Q9NPZ5	details
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1	B3GAT1	11q25	Q9P2W7	details
Polypeptide N-acetylgalactosaminyltransferase 10	GALNT10	5q33.2	Q86SR1	details
Beta-1,4-galactosyltransferase 3	B4GALT3	1q21-q23	O60512	details
Beta-1,4-galactosyltransferase 4	B4GALT4	3q13.3	O60513	details
Glycogenin-1	GYG1	3q24-q25.1	P46976	details
Histo-blood group ABO system transferase	ABO	9q34.2	P16442	details
Chondroitin sulfate synthase 3	CHSY3	5q23.3	Q70JA7	details
Chondroitin sulfate synthase 2	CHPF	2q35	Q8IZ52	details
Chondroitin sulfate synthase 1	CHSY1	15q26.3	Q86X52	details
Exostosin-like 3	EXTL3	8p21	O43909	details
Beta-1,4-galactosyltransferase 7	B4GALT7	5q35.2-q35.3	Q9UBV7	details
Chondroitin sulfate N-acetylgalactosaminyltransferase 2	CSGALNACT2	10q11.21	Q8N6G5	details
Exostosin-like 2	EXTL2	1p21	Q9UBQ6	details
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A	MGAT4A	2q12	Q9UM21	details
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B	MGAT4B	5q35	Q9UQ53	details
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	C1GALT1	7p21.3	Q9NS00	details
Beta-1,4-galactosyltransferase 6	B4GALT6	18q11	Q9UBX8	details
Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	8q23.1	Q7LG56	details
Polypeptide N-acetylgalactosaminyltransferase-like 6	GALNTL6	4q34.1	Q49A17	details
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	MGAT1	5q35	P26572	details
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C	MGAT4C	12q21	Q9UBM8	details
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B	MGAT5B	17q25.2	Q3V5L5	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	OGT	Xq13	O15294	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ribonucleoside-diphosphate reductase subunit M2	RRM2	2p25-p24	P31350	details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
Hyaluronan synthase 3	HAS3	16q22.1	O00219	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000295

DrugBank ID

DB03435

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

Not Available

PubChem Compound

6031

PDB ID

Not Available

ChEBI ID

17659

References

General References

Not Available

Only showing the first 10 proteins. There are 191 proteins in total.

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Enzymes

Enzyme Details

1. UMP-CMP kinase

General function:: Involved in ATP binding
Specific function:: Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.
Gene Name:: CMPK1
Uniprot ID:: P30085
Molecular weight:: 20180.12

Enzyme Details

2. Ectonucleoside triphosphate diphosphohydrolase 1

General function:: Involved in hydrolase activity
Specific function:: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:: ENTPD1
Uniprot ID:: P49961
Molecular weight:: 58706.0

Enzyme Details

3. Soluble calcium-activated nucleotidase 1

General function:: Involved in calcium ion binding
Specific function:: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:: CANT1
Uniprot ID:: Q8WVQ1
Molecular weight:: 44839.24

Enzyme Details

4. Ectonucleoside triphosphate diphosphohydrolase 3

General function:: Involved in hydrolase activity
Specific function:: Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:: ENTPD3
Uniprot ID:: O75355
Molecular weight:: 59104.76

Enzyme Details

5. Uridine-cytidine kinase 1

General function:: Involved in ATP binding
Specific function:: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Gene Name:: UCK1
Uniprot ID:: Q9HA47
Molecular weight:: 22760.43

Enzyme Details

6. Nucleoside diphosphate kinase, mitochondrial

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).
Gene Name:: NME4
Uniprot ID:: O00746
Molecular weight:: 20658.45

Enzyme Details

7. Ribonucleoside-diphosphate reductase large subunit

General function:: Involved in oxidation reduction
Specific function:: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Gene Name:: RRM1
Uniprot ID:: P23921
Molecular weight:: 90069.375

Enzyme Details

8. Nucleoside diphosphate kinase A

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Gene Name:: NME1
Uniprot ID:: P15531
Molecular weight:: 17148.635

Enzyme Details

9. Nucleoside diphosphate kinase 7

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Gene Name:: NME7
Uniprot ID:: Q9Y5B8
Molecular weight:: 42491.365

Enzyme Details

10. Ribonucleoside-diphosphate reductase subunit M2

General function:: Involved in oxidoreductase activity
Specific function:: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Gene Name:: RRM2
Uniprot ID:: P31350
Molecular weight:: 44877.25

Only showing the first 10 proteins. There are 191 proteins in total.

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Showing Compound Card for Uridine 5'-diphosphate (CDB005147)

Structure for CDB005147 (Uridine 5'-diphosphate)

Enzymes