Identification
HMDB Protein ID CDBP00886
Secondary Accession Numbers Not Available
Name Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
Description Not Available
Synonyms
  1. Down syndrome critical region protein 5
  2. Down syndrome critical region protein C
  3. PIG-P
  4. Phosphatidylinositol-glycan biosynthesis class P protein
Gene Name PIGP
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatidylinositol N-acetylglucosaminyltr
Specific Function Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
GO Classification
Biological Process
C-terminal protein lipidation
preassembly of GPI anchor in ER membrane
Cellular Component
endoplasmic reticulum membrane
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
integral to membrane
Molecular Function
phosphatidylinositol N-acetylglucosaminyltransferase activity
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location 21
Locus 21q22.2
SNPs PIGP
Gene Sequence
>477 bp
ATGGTGCCACGGAGCACATCGCTGACGCTGATTGTGTTCCTTTTCCACAGATTGTCTAAA
GCCCCAGGAAAAATGGTGGAAAATTCACCGTCGCCATTGCCAGAAAGAGCGATTTATGGC
TTTGTTCTTTTCTTAAGCTCCCAATTTGGCTTCATACTTTACCTCGTGTGGGCCTTTATT
CCTGAATCTTGGCTAAACTCTTTAGGTTTAACCTATTGGCCTCAAAAATATTGGGCAGTT
GCATTACCTGTCTACCTCCTTATTGCTATAGTAATTGGCTACGTGCTCTTGTTTGGGATT
AACATGATGAGTACCTCTCCACTCGACTCCATCCATACAATCACAGATAACTATGCAAAA
AATCAACAGCAGAAGAAATACCAAGAGGAGGCCATTCCAGCCTTAAGAGATATTTCTATT
AGTGAAGTAAACCAAATGTTCTTTCTTGCAGCCAAAGAACTTTACACCAAAAACTGA
Protein Properties
Number of Residues 158
Molecular Weight 18089.055
Theoretical pI 8.852
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
MVPRSTSLTLIVFLFHRLSKAPGKMVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFI
PESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAK
NQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYTKN
GenBank ID Protein 24497597
UniProtKB/Swiss-Prot ID P57054
UniProtKB/Swiss-Prot Entry Name PIGP_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_153681.2
GeneCard ID PIGP
GenAtlas ID PIGP
HGNC ID HGNC:3046
References
General References Not Available