| Identification |
|---|
| HMDB Protein ID
| CDBP00886 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphatidylinositol N-acetylglucosaminyltransferase subunit P |
| Description
| Not Available |
| Synonyms
|
- Down syndrome critical region protein 5
- Down syndrome critical region protein C
- PIG-P
- Phosphatidylinositol-glycan biosynthesis class P protein
|
| Gene Name
| PIGP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatidylinositol N-acetylglucosaminyltr |
| Specific Function
| Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
|
| GO Classification
|
| Biological Process |
| C-terminal protein lipidation |
| preassembly of GPI anchor in ER membrane |
| Cellular Component |
| endoplasmic reticulum membrane |
| glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex |
| integral to membrane |
| Molecular Function |
| phosphatidylinositol N-acetylglucosaminyltransferase activity |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | glycosylphosphatidylinositol-anchor biosynthesis | Not Available | Not Available | | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| 21q22.2 |
| SNPs
| PIGP |
| Gene Sequence
|
>477 bp
ATGGTGCCACGGAGCACATCGCTGACGCTGATTGTGTTCCTTTTCCACAGATTGTCTAAA
GCCCCAGGAAAAATGGTGGAAAATTCACCGTCGCCATTGCCAGAAAGAGCGATTTATGGC
TTTGTTCTTTTCTTAAGCTCCCAATTTGGCTTCATACTTTACCTCGTGTGGGCCTTTATT
CCTGAATCTTGGCTAAACTCTTTAGGTTTAACCTATTGGCCTCAAAAATATTGGGCAGTT
GCATTACCTGTCTACCTCCTTATTGCTATAGTAATTGGCTACGTGCTCTTGTTTGGGATT
AACATGATGAGTACCTCTCCACTCGACTCCATCCATACAATCACAGATAACTATGCAAAA
AATCAACAGCAGAAGAAATACCAAGAGGAGGCCATTCCAGCCTTAAGAGATATTTCTATT
AGTGAAGTAAACCAAATGTTCTTTCTTGCAGCCAAAGAACTTTACACCAAAAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 158 |
| Molecular Weight
| 18089.055 |
| Theoretical pI
| 8.852 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
MVPRSTSLTLIVFLFHRLSKAPGKMVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFI
PESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAK
NQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYTKN
|
| External Links |
|---|
| GenBank ID Protein
| 24497597 |
| UniProtKB/Swiss-Prot ID
| P57054 |
| UniProtKB/Swiss-Prot Entry Name
| PIGP_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_153681.2 |
| GeneCard ID
| PIGP |
| GenAtlas ID
| PIGP |
| HGNC ID
| HGNC:3046 |
| References |
|---|
| General References
| Not Available |