| Identification |
|---|
| HMDB Protein ID
| CDBP00877 |
| Secondary Accession Numbers
| Not Available |
| Name
| Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 |
| Description
| Not Available |
| Synonyms
|
- Beta-1,3-glucuronyltransferase 2
- GlcAT-D
- GlcAT-S
- Glucuronosyltransferase S
- UDP-glucuronosyltransferase S
|
| Gene Name
| B3GAT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity |
| Specific Function
| Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins (By similarity).
|
| GO Classification
|
| Biological Process |
| protein glycosylation |
| carbohydrate metabolic process |
| chondroitin sulfate metabolic process |
| Cellular Component |
| integral to membrane |
| Golgi membrane |
| Component |
| membrane |
| cell part |
| Function |
| transferase activity |
| glucuronosyltransferase activity |
| galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity |
| udp-glycosyltransferase activity |
| transferase activity, transferring glycosyl groups |
| catalytic activity |
| Molecular Function |
| metal ion binding |
| galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Other types of O-glycan biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6q13 |
| SNPs
| B3GAT2 |
| Gene Sequence
|
>972 bp
ATGAAGTCCGCGCTTTTCACCCGCTTCTTTATCCTCCTGCCCTGGATCCTAATTGTCATC
ATCATGCTCGACGTGGACACGCGCAGGCCAGTGCCCCCGCTCACCCCGCGCCCCTACTTC
TCTCCCTACGCGGTGGGCCGCGGGGGCGCCCGACTCCCGCTCCGCAGGGGCGGCCCGGCT
CACGGGACCCAAAAGCGCAACCAGTCTCGGCCGCAGCCACAGCCGGAGCCGCAGCTGCCC
ACCATCTATGCCATCACGCCCACCTACAGCCGCCCGGTGCAGAAAGCGGAGCTGACCCGC
CTGGCCAACACGTTCCGCCAGGTGGCGCAGCTGCACTGGATCCTGGTGGAGGACGCGGCG
GCGCGCAGCGAGCTGGTGAGCCGCTTCCTGGCGCGGGCCGGGCTGCCCAGCACTCACCTG
CACGTGCCCACGCCGCGGCGCTACAAGCGGCCCGGGCTGCCGCGCGCCACTGAGCAGCGC
AACGCGGGCCTCGCCTGGCTGCGCCAGAGGCACCAGCACCAGCGCGCGCAGCCCGGCGTG
CTCTTCTTCGCTGACGACGACAACACCTATAGTCTGGAGCTCTTCCAGGAGATGCGAACC
ACCCGCAAGGTCTCCGTCTGGCCTGTGGGCCTGGTTGGTGGGCGGCGCTACGAACGTCCG
CTGGTGGAAAACGGCAAAGTTGTTGGCTGGTACACCGGCTGGAGAGCAGACAGGCCTTTT
GCCATCGACATGGCAGGATTTGCTGTAAGTCTTCAAGTCATTTTGTCCAATCCAAAAGCT
GTATTTAAGCGTCGTGGATCCCAGCCAGGGATGCAAGAATCTGACTTTCTCAAACAGATA
ACAACAGTCGAAGAACTGGAACCGAAAGCAAATAACTGCACTAAGGTTCTCGTGTGGCAC
ACTCGGACAGAGAAGGTTAATCTAGCCAACGAGCCAAAGTACCACCTGGACACAGTGAAA
ATTGAGGTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 323 |
| Molecular Weight
| 36918.42 |
| Theoretical pI
| 10.629 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
MKSALFTRFFILLPWILIVIIMLDVDTRRPVPPLTPRPYFSPYAVGRGGARLPLRRGGPA
HGTQKRNQSRPQPQPEPQLPTIYAITPTYSRPVQKAELTRLANTFRQVAQLHWILVEDAA
ARSELVSRFLARAGLPSTHLHVPTPRRYKRPGLPRATEQRNAGLAWLRQRHQHQRAQPGV
LFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRYERPLVENGKVVGWYTGWRADRPF
AIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESDFLKQITTVEELEPKANNCTKVLVWH
TRTEKVNLANEPKYHLDTVKIEV
|
| External Links |
|---|
| GenBank ID Protein
| 18152775 |
| UniProtKB/Swiss-Prot ID
| Q9NPZ5 |
| UniProtKB/Swiss-Prot Entry Name
| B3GA2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_080742.2 |
| GeneCard ID
| B3GAT2 |
| GenAtlas ID
| B3GAT2 |
| HGNC ID
| HGNC:922 |
| References |
|---|
| General References
| Not Available |