| Identification |
|---|
| HMDB Protein ID
| CDBP00876 |
| Secondary Accession Numbers
| Not Available |
| Name
| Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 |
| Description
| Not Available |
| Synonyms
|
- Beta-1,3-glucuronyltransferase 3
- GlcAT-I
- GlcUAT-I
- Glucuronosyltransferase I
- UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase
|
| Gene Name
| B3GAT3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity |
| Specific Function
| Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc.
|
| GO Classification
|
| Biological Process |
| heparan sulfate proteoglycan biosynthetic process |
| protein glycosylation |
| carbohydrate metabolic process |
| chondroitin sulfate metabolic process |
| chondroitin sulfate proteoglycan biosynthetic process |
| dermatan sulfate proteoglycan biosynthetic process |
| Cellular Component |
| cis-Golgi network |
| integral to membrane |
| Golgi membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| transferase activity |
| glucuronosyltransferase activity |
| galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity |
| udp-glycosyltransferase activity |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| manganese ion binding |
| galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | Not Available |  | | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q12.3 |
| SNPs
| B3GAT3 |
| Gene Sequence
|
>1008 bp
ATGAAGCTGAAGCTGAAGAACGTGTTTCTCGCCTACTTCCTGGTGTCGATCGCCGGCCTC
CTCTACGCGCTGGTACAGCTCGGCCAGCCATGTGACTGCCTTCCTCCCCTGCGGGCAGCA
GCCGAGCAGCTACGGCAGAAGGATCTGAGGATTTCCCAGCTGCAAGCGGAACTCCGACGG
CCACCCCCTGCCCCTGCCCAGCCCCCTGAACCCGAGGCCCTGCCTACTATCTATGTTGTT
ACCCCCACCTATGCCAGGCTGGTACAGAAGGCAGAGCTGGTACGACTGTCCCAGACACTG
AGCCTGGTGCCCCGGCTGCATTGGCTGCTGGTGGAGGATGCTGAGGGTCCCACCCCGCTG
GTCTCAGGGCTGCTGGCTGCCTCTGGCCTCCTCTTCACACACCTGGTGGTCCTCACGCCC
AAAGCCCAGCGGCTTCGGGAGGGCGAGCCTGGCTGGGTTCATCCCCGTGGTGTCGAGCAG
CGGAACAAGGCCCTGGACTGGCTCCGGGGCAGAGGGGGTGCTGTGGGTGGGGAGAAGGAC
CCACCACCACCAGGGACCCAAGGAGTCGTTTACTTTGCTGACGATGACAACACCTACAGC
CGGGAGCTGTCTGAGGAGATGCGCTGGACCCGTGGTGTCTCAGTGTGGCCTGTGGGGCTG
GTGGGCGGCCTGCGATTCGAGGGCCCTCAGGTACAGGACGGCCGGGTAGTGGGCTTCCAC
ACAGCATGGGAGCCCAGCAGGCCCTTCCCTGTGGATATGGCTGGATTTGCCGTGGCCCTG
CCCTTGCTGTTAGATAAGCCCAATGCCCAATTTGATTCCACCGCTCCCCGGGGCCACCTG
GAGAGCAGTCTTCTGAGCCACCTTGTGGATCCCAAGGACCTGGAGCCACGGGCTGCCAAC
TGCACTCGGGTACTGGTGTGGCATACTCGGACAGAGAAGCCCAAGATGAAGCAGGAGGAG
CAGCTGCAGCGGCAGGGCCGGGGCTCAGACCCAGCAATTGAGGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 335 |
| Molecular Weight
| 37121.52 |
| Theoretical pI
| 8.272 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
MKLKLKNVFLAYFLVSIAGLLYALVQLGQPCDCLPPLRAAAEQLRQKDLRISQLQAELRR
PPPAPAQPPEPEALPTIYVVTPTYARLVQKAELVRLSQTLSLVPRLHWLLVEDAEGPTPL
VSGLLAASGLLFTHLVVLTPKAQRLREGEPGWVHPRGVEQRNKALDWLRGRGGAVGGEKD
PPPPGTQGVVYFADDDNTYSRELFEEMRWTRGVSVWPVGLVGGLRFEGPQVQDGRVVGFH
TAWEPSRPFPVDMAGFAVALPLLLDKPNAQFDSTAPRGHLESSLLSHLVDPKDLEPRAAN
CTRVLVWHTRTEKPKMKQEEQLQRQGRGSDPAIEV
|
| External Links |
|---|
| GenBank ID Protein
| 3892640 |
| UniProtKB/Swiss-Prot ID
| O94766 |
| UniProtKB/Swiss-Prot Entry Name
| B3GA3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB009598 |
| GeneCard ID
| B3GAT3 |
| GenAtlas ID
| B3GAT3 |
| HGNC ID
| HGNC:923 |
| References |
|---|
| General References
| Not Available |