| Identification |
|---|
| HMDB Protein ID
| CDBP00817 |
| Secondary Accession Numbers
| Not Available |
| Name
| Lactosylceramide 4-alpha-galactosyltransferase |
| Description
| Not Available |
| Synonyms
|
- Alpha-1,4-N-acetylglucosaminyltransferase
- Alpha-1,4-galactosyltransferase
- Alpha4Gal-T1
- CD77 synthase
- Gb3 synthase
- Globotriaosylceramide synthase
- P1/Pk synthase
- UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
|
| Gene Name
| A4GALT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in galactosyltransferase activity |
| Specific Function
| Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.
|
| GO Classification
|
| Biological Process |
| glycosphingolipid biosynthetic process |
| plasma membrane organization |
| protein glycosylation |
| Cellular Component |
| Golgi stack |
| integral to Golgi membrane |
| Component |
| golgi apparatus part |
| golgi stack |
| cell part |
| intracellular part |
| cytoplasmic part |
| Function |
| galactosyltransferase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring hexosyl groups |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| galactosyltransferase activity |
| lactosylceramide 4-alpha-galactosyltransferase activity |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein (Probable)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Glycosphingolipid biosynthesis - globo series | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| 22q13.2 |
| SNPs
| A4GALT |
| Gene Sequence
|
>1062 bp
ATGTCCAAGCCCCCCGACCTCCTGCTGCGGCTGCTCCGGGGCGCCCCAAGGCAGCGGGTC
TGCACCCTGTTCATCATCGGCTTCAAGTTCACGTTTTTCGTCTCCATCATGATCTACTGG
CACGTTGTGGGAGAGCCCAAGGAGAAAGGGCAGCTCTATAACCTGCCAGCAGAGATCCCC
TGCCCCACCTTGACACCCCCCACCCCACCCTCCCACGGCCCCACTCCAGGCAACATCTTC
TTCCTGGAGACTTCAGACCGGACCAACCCCAACTTCCTGTTCATGTGCTCGGTGGAGTCG
GCCGCCAGAACTCACCCCGAATCCCACGTGCTGGTCCTGATGAAAGGGCTTCCGGGTGGC
AACGCCTCTCTGCCCCGGCACCTGGGCATCTCACTTCTGAGCTGCTTCCCGAATGTCCAG
ATGCTCCCGCTGGACCTGCGGGAGCTGTTCCGGGACACACCCCTGGCCGACTGGTACGCG
GCCGTGCAGGGGCGCTGGGAGCCCTACCTGCTGCCCGTGCTCTCCGACGCCTCCAGGATC
GCACTCATGTGGAAGTTCGGCGGCATCTACCTGGACACGGACTTCATTGTTCTCAAGAAC
CTGCGGAACCTGACCAACGTGCTGGGCACCCAGTCCCGCTACGTCCTCAACGGCGCGTTC
CTGGCCTTCGAGCGCCGGCACGAGTTCATGGCGCTGTGCATGCGGGACTTCGTGGACCAC
TACAACGGCTGGATCTGGGGTCACCAGGGCCCGCAGCTGCTCACGCGGGTCTTCAAGAAG
TGGTGTTCCATCCGCAGCCTGGCCGAGAGCCGCGCCTGCCGCGGCGTCACCACCCTGCCC
CCTGAGGCCTTCTACCCCATCCCCTGGCAGGACTGGAAGAAGTACTTTGAGGACATCAAC
CCGGAGGAGCTGCCGCGGCTGCTCAGTGCCACCTATGCTGTCCACGTGTGGAACAAGAAG
AGCCAGGGCACGCGGTTCGAGGCCACGTCCAGGGCACTGCTGGCCCAGCTGCATGCCCGC
TACTGCCCCACGACGCACGAGGCCATGAAAATGTACTTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 353 |
| Molecular Weight
| 40498.78 |
| Theoretical pI
| 8.96 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Lactosylceramide 4-alpha-galactosyltransferase
MSKPPDLLLRLLRGAPRQRVCTLFIIGFKFTFFVSIMIYWHVVGEPKEKGQLYNLPAEIP
CPTLTPPTPPSHGPTPGNIFFLETSDRTNPNFLFMCSVESAARTHPESHVLVLMKGLPGG
NASLPRHLGISLLSCFPNVQMLPLDLRELFRDTPLADWYAAVQGRWEPYLLPVLSDASRI
ALMWKFGGIYLDTDFIVLKNLRNLTNVLGTQSRYVLNGAFLAFERRHEFMALCMRDFVDH
YNGWIWGHQGPQLLTRVFKKWCSIRSLAESRACRGVTTLPPEAFYPIPWQDWKKYFEDIN
PEELPRLLSATYAVHVWNKKSQGTRFEATSRALLAQLHARYCPTTHEAMKMYL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9NPC4 |
| UniProtKB/Swiss-Prot Entry Name
| A4GAT_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB037883 |
| GeneCard ID
| A4GALT |
| GenAtlas ID
| A4GALT |
| HGNC ID
| HGNC:18149 |
| References |
|---|
| General References
| Not Available |