| Identification |
|---|
| HMDB Protein ID
| CDBP01034 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histo-blood group ABO system transferase |
| Description
| Not Available |
| Synonyms
|
- A transferase
- B transferase
- Fucosylglycoprotein 3-alpha-galactosyltransferase
- Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
- Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form
- Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
- Glycoprotein-fucosylgalactoside alpha-galactosyltransferase
- Histo-blood group A transferase
- Histo-blood group B transferase
- NAGAT
|
| Gene Name
| ABO |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transferase activity, transferring hexosyl groups |
| Specific Function
| This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
|
| GO Classification
|
| Biological Process |
| protein glycosylation |
| Cellular Component |
| Golgi cisterna membrane |
| integral to Golgi membrane |
| extracellular region |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring hexosyl groups |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| fucosylgalactoside 3-alpha-galactosyltransferase activity |
| glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity |
| metal ion binding |
| Process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
|
| Cellular Location
|
- Secreted
- Single-pass type II membrane protein
- Golgi apparatus
- Golgi stack membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Glycosphingolipid biosynthesis - lacto and neolacto series | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q34.2 |
| SNPs
| ABO |
| Gene Sequence
|
>1065 bp
ATGGCCGAGGTGTTGCGGACGCTGGCCGGAAAACCAAAATGCCACGCACTTCGACCTATG
ATCCTTTTCCTAATAATGCTTGTCTTGGTCTTGTTTGGTTACGGGGTCCTAAGCCCCAGA
AGTCTAATGCCAGGAAGCCTGGAACGGGGGTTCTGCATGGCTGTTAGGGAACCTGACCAT
CTGCAGCGCGTCTCGTTGCCAAGGATGGTCTACCCCCAGCCAAAGGTGCTGACACCGTGT
AGGAAGGATGTCCTCGTGGTGACCCCTTGGCTGGCTCCCATTGTCTGGGAGGGCACATTC
AACATCGACATCCTCAACGAGCAGTTCAGGCTCCAGAACACCACCATTGGGTTAACTGTG
TTTGCCATCAAGAAATACGTGGCTTTCCTGAAGCTGTTCCTGGAGACGGCGGAGAAGCAC
TTCATGGTGGGCCACCGTGTCCACTACTATGTCTTCACCGACCAGCCGGCCGCGGTGCCC
CGCGTGACGCTGGGGACCGGTCGGCAGCTGTCAGTGCTGGAGGTGCGCGCCTACAAGCGC
TGGCAGGACGTGTCCATGCGCCGCATGGAGATGATCAGTGACTTCTGCGAGCGGCGCTTC
CTCAGCGAGGTGGATTACCTGGTGTGCGTGGACGTGGACATGGAGTTCCGCGACCACGTG
GGCGTGGAGATCCTGACTCCGCTGTTCGGCACCCTGCACCCCGGCTTCTACGGAAGCAGC
CGGGAGGCCTTCACCTACGAGCGCCGGCCCCAGTCCCAGGCCTACATCCCCAAGGACGAG
GGCGATTTCTACTACCTGGGGGGGTTCTTCGGGGGGTCGGTGCAAGAGGTGCAGCGGCTC
ACCAGGGCCTGCCACCAGGCCATGATGGTCGACCAGGCCAACGGCATCGAGGCCGTGTGG
CACGACGAGAGCCACCTGAACAAGTACCTGCTGCGCCACAAACCCACCAAGGTGCTCTCC
CCCGAGTACTTGTGGGACCAGCAGCTGCTGGGCTGGCCCGCCGTCCTGAGGAAGCTGAGG
TTCACTGCGGTGCCCAAGAACCACCAGGCGGTCCGGAACCCGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 354 |
| Molecular Weight
| 40933.555 |
| Theoretical pI
| 8.989 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histo-blood group ABO system transferase
MAEVLRTLAGKPKCHALRPMILFLIMLVLVLFGYGVLSPRSLMPGSLERGFCMAVREPDH
LQRVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTV
FAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKR
WQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSS
REAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVW
HDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVPKNHQAVRNP
|
| External Links |
|---|
| GenBank ID Protein
| 58331216 |
| UniProtKB/Swiss-Prot ID
| P16442 |
| UniProtKB/Swiss-Prot Entry Name
| BGAT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_020469.2 |
| GeneCard ID
| ABO |
| GenAtlas ID
| ABO |
| HGNC ID
| HGNC:79 |
| References |
|---|
| General References
| Not Available |