Cannabis Compound Database: Showing Protein Beta-1,4-galactosyltransferase 1 (CDBP00369)

Identification Biological properties Gene properties Protein properties External links References XML Show 4 compounds

Identification

HMDB Protein ID

CDBP00369

Secondary Accession Numbers

Not Available

Name

Beta-1,4-galactosyltransferase 1

Description

Not Available

Synonyms

Beta-1,4-GalTase 1
Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
Beta4Gal-T1
Lactose synthase A protein
N-acetyllactosamine synthase
Nal synthase
Processed beta-1,4-galactosyltransferase 1
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
b4Gal-T1

Gene Name

B4GALT1

Protein Type

Enzyme

Biological Properties

General Function

Involved in transferase activity, transferring glycosyl groups

Specific Function

The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.

GO Classification

Biological Process
negative regulation of cell proliferation
development of secondary sexual characteristics
binding of sperm to zona pellucida
epithelial cell development
extracellular matrix organization
galactose metabolic process
lactose biosynthetic process
leukocyte migration
mammary gland development
Notch signaling pathway
penetration of zona pellucida
positive regulation of apoptotic process involved in mammary gland involution
positive regulation of epithelial cell proliferation involved in wound healing
regulation of acrosome reaction
oligosaccharide biosynthetic process
regulation of cellular component movement
keratan sulfate biosynthetic process
cell adhesion
acute inflammatory response
post-translational protein modification
angiogenesis involved in wound healing
protein N-linked glycosylation via asparagine
branching morphogenesis of a tube
Cellular Component
Golgi cisterna membrane
desmosome
glycocalyx
Golgi trans cisterna
basolateral plasma membrane
extracellular region
brush border membrane
external side of plasma membrane
integral to membrane
Golgi membrane
Function
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
Molecular Function
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
lactose synthase activity
N-acetyllactosamine synthase activity
metal ion binding
protein homodimerization activity
alpha-tubulin binding
Process
metabolic process
primary metabolic process
carbohydrate metabolic process

Cellular Location

Processed beta-1
4-galactosyltransferase 1:Secreted

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein glycosylation	Not Available	Not Available
N-Glycan biosynthesis	Not Available
Other types of O-glycan biosynthesis	Not Available
Glycosaminoglycan biosynthesis - keratan sulfate	Not Available
Glycosphingolipid biosynthesis - lacto and neolacto series	Not Available

Gene Properties

Chromosome Location

Locus

9p13

SNPs

B4GALT1

Gene Sequence

>1197 bp
ATGAGGCTTCGGGAGCCGCTCCTGAGCGGCAGCGCCGCGATGCCAGGCGCGTCCCTACAG
CGGGCCTGCCGCCTGCTCGTGGCCGTCTGCGCTCTGCACCTTGGCGTCACCCTCGTTTAC
TACCTGGCTGGCCGCGACCTGAGCCGCCTGCCCCAACTGGTCGGAGTCTCCACACCGCTG
CAGGGCGGCTCGAACAGTGCCGCCGCCATCGGGCAGTCCTCCGGGGAGCTCCGGACCGGA
GGGGCCCGGCCGCCGCCTCCTCTAGGCGCCTCCTCCCAGCCGCGCCCGGGTGGCGACTCC
AGCCCAGTCGTGGATTCTGGCCCTGGCCCCGCTAGCAACTTGACCTCGGTCCCAGTGCCC
CACACCACCGCACTGTCGCTGCCCGCCTGCCCTGAGGAGTCCCCGCTGCTTGTGGGCCCC
ATGCTGATTGAGTTTAACATGCCTGTGGACCTGGAGCTCGTGGCAAAGCAGAACCCAAAT
GTGAAGATGGGCGGCCGCTATGCCCCCAGGGACTGCGTCTCTCCTCACAAGGTGGCCATC
ATCATTCCATTCCGCAACCGGCAGGAGCACCTCAAGTACTGGCTATATTATTTGCACCCA
GTCCTGCAGCGCCAGCAGCTGGACTATGGCATCTATGTTATCAACCAGGCGGGAGACACT
ATATTCAATCGTGCTAAGCTCCTCAATGTTGGCTTTCAAGAAGCCTTGAAGGACTATGAC
TACACCTGCTTTGTGTTTAGCGACGTGGACCTCATTCCAATGAATGACCATAATGCGTAC
AGGTGTTTTTCACAGCCACGGCACATTTCCGTTGCAATGGATAAGTTTGGATTCAGCCTA
CCTTATGTTCAGTATTTTGGAGGTGTCTCTGCTCTAAGTAAACAACAGTTTCTAACCATC
AATGGATTTCCTAATAATTATTGGGGCTGGGGAGGAGAAGATGATGACATTTTTAACAGA
TTAGTTTTTAGAGGCATGTCTATATCTCGCCCAAATGCTGTGGTCGGGAGGTGTCGCATG
ATCCGCCACTCAAGAGACAAGAAAAATGAACCCAATCCTCAGAGGTTTGACCGAATTGCA
CACACAAAGGAGACAATGCTCTCTGATGGTTTGAACTCACTCACCTACCAGGTGCTGGAT
GTACAGAGATACCCATTGTATACCCAAATCACAGTGGACATCGGGACACCGAGCTAG

Protein Properties

Number of Residues

398

Molecular Weight

43919.895

Theoretical pI

8.642

Pfam Domain Function

Galactosyl_T_2 (PF02709 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Beta-1,4-galactosyltransferase 1
MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPL
QGGSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVP
HTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAI
IIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYD
YTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLTI
NGFPNNYWGWGGEDDDIFNRLVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIA
HTKETMLSDGLNSLTYQVLDVQRYPLYTQITVDIGTPS

External Links

GenBank ID Protein

189053491

UniProtKB/Swiss-Prot ID

P15291

UniProtKB/Swiss-Prot Entry Name

B4GT1_HUMAN

PDB IDs