Identification |
HMDB Protein ID
| CDBP00369 |
Secondary Accession Numbers
| Not Available |
Name
| Beta-1,4-galactosyltransferase 1 |
Description
| Not Available |
Synonyms
|
- Beta-1,4-GalTase 1
- Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
- Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
- Beta4Gal-T1
- Lactose synthase A protein
- N-acetyllactosamine synthase
- Nal synthase
- Processed beta-1,4-galactosyltransferase 1
- UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1
- UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
- b4Gal-T1
|
Gene Name
| B4GALT1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in transferase activity, transferring glycosyl groups |
Specific Function
| The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
The cell surface form functions as a recognition molecule during a variety of cell to cell and cell to matrix interactions, as those occurring during development and egg fertilization, by binding to specific oligosaccharide ligands on opposing cells or in the extracellular matrix.
|
GO Classification
|
Biological Process |
lactose biosynthetic process |
leukocyte migration |
mammary gland development |
Notch signaling pathway |
penetration of zona pellucida |
positive regulation of apoptotic process involved in mammary gland involution |
positive regulation of epithelial cell proliferation involved in wound healing |
regulation of acrosome reaction |
oligosaccharide biosynthetic process |
regulation of cellular component movement |
keratan sulfate biosynthetic process |
cell adhesion |
acute inflammatory response |
post-translational protein modification |
angiogenesis involved in wound healing |
protein N-linked glycosylation via asparagine |
branching morphogenesis of a tube |
negative regulation of cell proliferation |
development of secondary sexual characteristics |
binding of sperm to zona pellucida |
epithelial cell development |
extracellular matrix organization |
galactose metabolic process |
Cellular Component |
glycocalyx |
Golgi trans cisterna |
basolateral plasma membrane |
extracellular region |
brush border membrane |
external side of plasma membrane |
integral to membrane |
Golgi membrane |
Golgi cisterna membrane |
desmosome |
Function |
catalytic activity |
transferase activity |
transferase activity, transferring glycosyl groups |
Molecular Function |
protein homodimerization activity |
alpha-tubulin binding |
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity |
lactose synthase activity |
N-acetyllactosamine synthase activity |
metal ion binding |
Process |
metabolic process |
primary metabolic process |
carbohydrate metabolic process |
|
Cellular Location
|
- Processed beta-1
- 4-galactosyltransferase 1:Secreted
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | protein glycosylation | Not Available | Not Available | N-Glycan biosynthesis | Not Available | | Other types of O-glycan biosynthesis | Not Available | | Glycosaminoglycan biosynthesis - keratan sulfate | Not Available | | Glycosphingolipid biosynthesis - lacto and neolacto series | Not Available | |
|
Gene Properties |
Chromosome Location
| 9 |
Locus
| 9p13 |
SNPs
| B4GALT1 |
Gene Sequence
|
>1197 bp
ATGAGGCTTCGGGAGCCGCTCCTGAGCGGCAGCGCCGCGATGCCAGGCGCGTCCCTACAG
CGGGCCTGCCGCCTGCTCGTGGCCGTCTGCGCTCTGCACCTTGGCGTCACCCTCGTTTAC
TACCTGGCTGGCCGCGACCTGAGCCGCCTGCCCCAACTGGTCGGAGTCTCCACACCGCTG
CAGGGCGGCTCGAACAGTGCCGCCGCCATCGGGCAGTCCTCCGGGGAGCTCCGGACCGGA
GGGGCCCGGCCGCCGCCTCCTCTAGGCGCCTCCTCCCAGCCGCGCCCGGGTGGCGACTCC
AGCCCAGTCGTGGATTCTGGCCCTGGCCCCGCTAGCAACTTGACCTCGGTCCCAGTGCCC
CACACCACCGCACTGTCGCTGCCCGCCTGCCCTGAGGAGTCCCCGCTGCTTGTGGGCCCC
ATGCTGATTGAGTTTAACATGCCTGTGGACCTGGAGCTCGTGGCAAAGCAGAACCCAAAT
GTGAAGATGGGCGGCCGCTATGCCCCCAGGGACTGCGTCTCTCCTCACAAGGTGGCCATC
ATCATTCCATTCCGCAACCGGCAGGAGCACCTCAAGTACTGGCTATATTATTTGCACCCA
GTCCTGCAGCGCCAGCAGCTGGACTATGGCATCTATGTTATCAACCAGGCGGGAGACACT
ATATTCAATCGTGCTAAGCTCCTCAATGTTGGCTTTCAAGAAGCCTTGAAGGACTATGAC
TACACCTGCTTTGTGTTTAGCGACGTGGACCTCATTCCAATGAATGACCATAATGCGTAC
AGGTGTTTTTCACAGCCACGGCACATTTCCGTTGCAATGGATAAGTTTGGATTCAGCCTA
CCTTATGTTCAGTATTTTGGAGGTGTCTCTGCTCTAAGTAAACAACAGTTTCTAACCATC
AATGGATTTCCTAATAATTATTGGGGCTGGGGAGGAGAAGATGATGACATTTTTAACAGA
TTAGTTTTTAGAGGCATGTCTATATCTCGCCCAAATGCTGTGGTCGGGAGGTGTCGCATG
ATCCGCCACTCAAGAGACAAGAAAAATGAACCCAATCCTCAGAGGTTTGACCGAATTGCA
CACACAAAGGAGACAATGCTCTCTGATGGTTTGAACTCACTCACCTACCAGGTGCTGGAT
GTACAGAGATACCCATTGTATACCCAAATCACAGTGGACATCGGGACACCGAGCTAG
|
Protein Properties |
Number of Residues
| 398 |
Molecular Weight
| 43919.895 |
Theoretical pI
| 8.642 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Beta-1,4-galactosyltransferase 1
MRLREPLLSGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLSRLPQLVGVSTPL
QGGSNSAAAIGQSSGELRTGGARPPPPLGASSQPRPGGDSSPVVDSGPGPASNLTSVPVP
HTTALSLPACPEESPLLVGPMLIEFNMPVDLELVAKQNPNVKMGGRYAPRDCVSPHKVAI
IIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQAGDTIFNRAKLLNVGFQEALKDYD
YTCFVFSDVDLIPMNDHNAYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLTI
NGFPNNYWGWGGEDDDIFNRLVFRGMSISRPNAVVGRCRMIRHSRDKKNEPNPQRFDRIA
HTKETMLSDGLNSLTYQVLDVQRYPLYTQITVDIGTPS
|
External Links |
GenBank ID Protein
| 189053491 |
UniProtKB/Swiss-Prot ID
| P15291 |
UniProtKB/Swiss-Prot Entry Name
| B4GT1_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AK312797 |
GeneCard ID
| B4GALT1 |
GenAtlas ID
| B4GALT1 |
HGNC ID
| HGNC:924 |
References |
General References
| Not Available |