Showing Protein Beta-1,4-N-acetylgalactosaminyltransferase 3 (CDBP04313)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP04313
Secondary Accession Numbers Not Available
Name Beta-1,4-N-acetylgalactosaminyltransferase 3
Description Not Available
Synonyms
  1. Beta-1,4-N-acetylgalactosaminyltransferase III
  2. Beta4GalNAc-T3
  3. Beta4GalNAcT3
  4. NGalNAc-T2
  5. B4GalNAcT3
  6. N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2
Gene Name B4GALNT3
Protein Type Enzyme
Biological Properties
General Function Involved in transferase activity, transferring hexosyl groups
Specific Function Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N'-diacetyllactosediamine formation on gastric mucosa.
GO Classification
Cellular Component
Golgi cisterna membrane
integral to membrane
Component
organelle membrane
golgi cisterna membrane
golgi membrane
membrane
cell part
Function
catalytic activity
transferase activity
transferase activity, transferring hexosyl groups
transferase activity, transferring glycosyl groups
Molecular Function
acetylgalactosaminyltransferase activity
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity
Cellular Location
  1. Single-pass type II membrane protein
  2. Golgi apparatus
  3. Golgi stack membrane
Pathways
Gene Properties
Chromosome Location 12
Locus 12p13.33
SNPs B4GALNT3
Gene Sequence 
>2997 bp
ATGGGGAGCCCCCGGGCCGCGCGGCCCCCGCTGCTCCTGCGCCCGGTGAAGCTGCTGCGG
AGGCGCTTCCGGCTGCTGCTGGCGCTCGCCGTGGTGTCTGTGGGGCTCTGGACTCTGTAT
CTGGAACTGGTGGCGTCGGCCCAGGTCGGCGGGAACCCCCTGAACCGGAGGTACGGCAGC
TGGAGAGAACTAGCCAAGGCTCTGGCCAGCAGGAACATTCCAGCTGTGGATCCACACCTC
CAGTTCTACCATCCCCAGAGGCTGAGCCTCGAGGACCACGACATTGACCAAGGGGTGAGC
AGTAACAGCAGCTACTTGAAGTGGAACAAGCCTGTCCCCTGGCTCTCAGAGTTCCGGGGC
CGTGCCAACCTGCATGTGTTTGAAGACTGGTGTGGCAGCTCTATCCAGCAGCTCAGGAGG
AACCTGCATTTCCCACTGTACCCCCATATTCGCACAACCCTGAGGAAGCTTGCTGTGTCC
CCCAAATGGACCAACTATGGCCTCCGCATCTTTGGCTACCTGCACCCCTTTACTGATGGG
AAAATCCAGTTTGCCATTGCTGCAGATGACAACGCGGAGTTCTGGCTGAGCCTCGATGAC
CAGGTCTCAGGCCTCCAGCTGCTGGCCAGTGTGGGCAAGACTGGAAAGGAGTGGACCGCC
CCGGGAGAGTTTGGGAAATTTCGGAGCCAAATTTCCAAGCCGGTGAGCCTGTCAGCCTCC
CACAGGTACTACTTCGAGGTGCTGCACAAGCAGAATGAGGAGGGCACCGACCACGTGGAA
GTTGCATGGCGACGGAACGACCCTGGAGCCAAGTTCACCATCATTGACTCCCTCTCCCTG
TCCCTCTTCACAAATGAGACGTTCCTACAGATGGATGAGGTGGGCCACATCCCACAGACA
GCAGCCAGCCACGTGGACTCCTCCAACGCTCTTCCCAGGGATGAGCAGCCGCCCGCTGAC
ATGCTTCGGCCTGACCCCCGGGACACCCTCTATCGAGTGCCTCTGATCCCCAAGTCGCAT
CTCCGCCACGTCCTGCCTGACTGTCCCTACAAACCCAGCTATCTGGTGGATGGGCTTCCT
CTGCAGCGCTACCAGGGACTCCGGTTTGTTCATCTGTCTTTTGTTTACCCCAATGACTAT
ACCCGCCTGAGCCACATGGAGACCCACAATAAATGTTTCTACCAGGAAAACGCCTACTAC
CAAGACCGGTTCAGCTTTCAGGAGTACATCAGGATTGACCAGCCTGAGAAGCAGGGGCTG
GAGCAGCCAGGTTTTGAGGAAAACCTTCTAGAAGAGTCCCAGTATGGGGAAGTGGCAGAG
GAGACCCCTGCCTCCAACAACCAGAATGCCAGGATGCTTGAGGGAAGACAGACACCTGCC
TCCACCCTGGAGCAAGATGCCACTGACTACCGCCTCCGAAGCCTGCGGAAACTCCTGGCT
CAGCCCCGGGAGGGCCTGCTGGCCCCCTTCTCCAAGCGGAACTCCACAGCGTCCTTCCCA
GGGAGGACCAGCCACATTCCAGTGCAGCAGCCAGAGAAGAGGAAGCAAAAACCCAGCCCT
GAGCCCAGCCAAGATTCACCTCATTCCGACAAGTGGCCTCCTGGGCACCCTGTGAAGAAC
CTGCCTCAGATGAGGGGGCCCAGGCCCAGGCCCGCTGGTGACAGCCCCAGGAAGACTCAG
TGGCTGAACCAGGTGGAGTCGTACATCGCAGAGCAGAGACGGGGTGACAGGATGCGGCCT
CAGGCCCCCGGAAGGGGCTGGCATGGGGAGGAGGAAGTGGTGGCGGCCGCAGGCCAGGAA
GGACAAGTGGAGGGAGAGGAAGAGGGGGAAGAAGAGGAGGAGGAAGAGGATATGAGTGAG
GTGTTCGAGTACGTACCTGTGTTTGACCCGGTAGTAAACTGGGACCAGACCTTCAGTGCC
CGGAATCTCGACTTCCAAGCCCTGAGGACTGACTGGATCGATCTGAGCTGTAACACATCT
GGCAACCTGCTGCTTCCAGAGCAGGAAGCTCTGGAGGTCACGCGAGTCTTCTTGAAGAAG
CTCAACCAGAGGAGCCGGGGGAGGTACCAGCTACAGCGCATTGTGAACGTGGAAAAGCGT
CAGGACCAGCTACGTGGGGGTCGCTACCTCCTGGAGCTTGAACTGTTGGAACAAGGCCAG
CGCGTGGTGCGGCTCTCGGAGTATGTGTCTGCACGAGGCTGGCAGGGCATCGATCCAGCT
GGTGGGGAGGAGGTCGAGGCCCGGAACCTGCAAGGCCTGGTCTGGGACCCACACAACCGT
AGGAGACAGGTCCTGAATACCCGGGCCCAAGAGCCCAAGCTGTGCTGGCCTCAGGGTTTC
TCCTGGAGTCACCGAGCCGTGGTCCACTTCGTCGTGCCTGTGAAGAACCAGGCACGCTGG
GTACAGCAATTCATCAAAGACATGGAAAACCTGTTCCAGGTCACCGGTGACCCACACTTC
AACATCGTCATCACTGACTATAGCAGTGAGGACATGGATGTTGAGATGGCACTGAAGAGG
TCCAAGCTGCGGAGCTACCAGTACGTGAAGCTAAGTGGAAACTTTGAACGCTCAGCTGGA
CTTCAGGCTGGCATAGACCTCGTGAAGGACCCGCACAGCATCATCTTCCTCTGTGACCTC
CACATCCACTTCCCAGCTGGAGTCATCGATGCCATTCGGAAGCACTGTGTGGAGGGAAAG
ATGGCCTTTGCCCCCATGGTGATGAGGCTGCATTGTGGGGCCACCCCCCAGTGGCCTGAG
GGCTACTGGGAGGTGAATGGGTTCGGGCTGCTTGGCATCTACAAGTCTGACCTGGACAGG
ATTGGGGGCATGAACACCAAGGAGTTCCGAGACCGCTGGGGCGGGGAAGACTGGGAGCTG
CTGGACAGGATACTCCAAGCGGGCCTGGACGTGGAGCGTCTCTCCCTCAGGAATTTCTTC
CATCATTTCCATTCCAAGCGAGGCATGTGGAGCCGTCGCCAGATGAAGACGCTGTAG
Protein Properties
Number of Residues 998
Molecular Weight 114974.105
Theoretical pI 7.489
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2
MGSPRAARPPLLLRPVKLLRRRFRLLLALAVVSVGLWTLYLELVASAQVGGNPLNRRYGS
WRELAKALASRNIPAVDPHLQFYHPQRLSLEDHDIDQGVSSNSSYLKWNKPVPWLSEFRG
RANLHVFEDWCGSSIQQLRRNLHFPLYPHIRTTLRKLAVSPKWTNYGLRIFGYLHPFTDG
KIQFAIAADDNAEFWLSLDDQVSGLQLLASVGKTGKEWTAPGEFGKFRSQISKPVSLSAS
HRYYFEVLHKQNEEGTDHVEVAWRRNDPGAKFTIIDSLSLSLFTNETFLQMDEVGHIPQT
AASHVDSSNALPRDEQPPADMLRPDPRDTLYRVPLIPKSHLRHVLPDCPYKPSYLVDGLP
LQRYQGLRFVHLSFVYPNDYTRLSHMETHNKCFYQENAYYQDRFSFQEYIKIDQPEKQGL
EQPGFEENLLEESQYGEVAEETPASNNQNARMLEGRQTPASTLEQDATDYRLRSLRKLLA
QPREGLLAPFSKRNSTASFPGRTSHIPVQQPEKRKQKPSPEPSQDSPHSDKWPPGHPVKN
LPQMRGPRPRPAGDSPRKTQWLNQVESYIAEQRRGDRMRPQAPGRGWHGEEEVVAAAGQE
GQVEGEEEGEEEEEEEDMSEVFEYVPVFDPVVNWDQTFSARNLDFQALRTDWIDLSCNTS
GNLLLPEQEALEVTRVFLKKLNQRSRGRYQLQRIVNVEKRQDQLRGGRYLLELELLEQGQ
RVVRLSEYVSARGWQGIDPAGGEEVEARNLQGLVWDPHNRRRQVLNTRAQEPKLCWPQGF
SWSHRAVVHFVVPVKNQARWVQQFIKDMENLFQVTGDPHFNIVITDYSSEDMDVEMALKR
SKLRSYQYVKLSGNFERSAGLQAGIDLVKDPHSIIFLCDLHIHFPAGVIDAIRKHCVEGK
MAFAPMVMRLHCGATPQWPEGYWEVNGFGLLGIYKSDLDRIGGMNTKEFRDRWGGEDWEL
LDRILQAGLDVERLSLRNFFHHFHSKRGMWSRRQMKTL
GenBank ID Protein 38564141
UniProtKB/Swiss-Prot ID Q6L9W6
UniProtKB/Swiss-Prot Entry Name B4GN3_HUMAN
PDB IDs Not Available
GenBank Gene ID AB089940
GeneCard ID B4GALNT3
GenAtlas ID B4GALNT3
HGNC ID HGNC:24137
References
General References Not Available