Showing Protein Beta-1,4-galactosyltransferase 2 (CDBP00363)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP00363
Secondary Accession Numbers Not Available
Name Beta-1,4-galactosyltransferase 2
Description Not Available
Synonyms
  1. Beta-1,4-GalTase 2
  2. Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
  3. Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
  4. Beta4Gal-T2
  5. Lactose synthase A protein
  6. N-acetyllactosamine synthase
  7. Nal synthase
  8. UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2
  9. UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2
  10. b4Gal-T2
Gene Name B4GALT2
Protein Type Enzyme
Biological Properties
General Function Involved in transferase activity, transferring glycosyl groups
Specific Function Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose.
GO Classification
Biological Process
post-translational protein modification
protein N-linked glycosylation via asparagine
keratan sulfate biosynthetic process
Cellular Component
Golgi cisterna membrane
integral to membrane
Golgi membrane
Function
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
Molecular Function
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
lactose synthase activity
N-acetyllactosamine synthase activity
metal ion binding
galactosyltransferase activity
Process
metabolic process
primary metabolic process
carbohydrate metabolic process
Cellular Location
  1. Single-pass type II membrane protein
  2. Golgi apparatus
  3. Golgi stack membrane
Pathways
Gene Properties
Chromosome Location 1
Locus 1p34-p33
SNPs B4GALT2
Gene Sequence 
>1119 bp
ATGAGCAGACTGCTGGGGGGGACGCTGGAGCGCGTCTGCAAGGCTGTGCTCCTTCTCTGC
CTGCTGCACTTCCTCGTGGCCGTCATCCTCTACTTTGACGTCTACGCCCAGCACCTGGCC
TTCTTCAGCCGCTTCAGTGCCCGAGGCCCTGCCCATGCCCTCCACCCAGCTGCTAGCAGC
AGCAGCAGCAGCAGCAACTGCTCCCGGCCCAACGCCACCGCCTCTAGCTCCGGGCTCCCT
GAGGTCCCCAGTGCCCTGCCCGGTCCCACGGCTCCCACGCTGCCACCCTGTCCTGACTCG
CCACCTGGTCTTGTGGGCAGACTGCTGATCGAGTTCACCTCACCCATGCCCCTGGAGCGG
GTGCAGAGGGAGAACCCAGGCGTGCTCATGGGCGGCCGATACACACCGCCCGACTGCACC
CCAGCCCAGACGGTGGCGGTCATCATCCCCTTTAGACACCGGGAACACCACCTGCGCTAC
TGGCTCCACTATCTACACCCCATCTTGAGGCGGCAGCGGCTGCGCTACGGCGTCTATGTC
ATCAACCAGCATGGTGAGGACACCTTCAACCGGGCCAAGCTGCTTAACGTGGGCTTCCTA
GAGGCGCTGAAGGAGGATGCCGCCTATGACTGCTTCATCTTCAGCGATGTGGACCTGGTC
CCCATGGATGACCGCAACCTATACCGCTGCGGCGACCAACCCCGCCACTTTGCCATTGCC
ATGGACAAGTTTGGCTTCCGGCTTCCCTATGCTGGCTACTTTGGAGGTGTGTCAGGCCTG
AGTAAGGCTCAGTTTCTGAGAATCAATGGCTTCCCCAATGAGTACTGGGGCTGGGGTGGC
GAGGATGATGACATCTTCAACCGGATCTCCCTGACTGGGATGAAGATCTCACGCCCAGAC
ATCCGAATTGGCCGCTACCGCATGATCAAGCACGACCGCGACAAGCATAACGAACCTAAC
CCTCAGAGGTTTACCAAGATTCAAAACACGAAGCTGACCATGAAGCGGGACGGCATTGGG
TCAGTGCGGTACCAGGTCTTGGAGGTGTCTCGGCAACCACTCTTCACCAATATCACAGTG
GACATTGGGCGGCCTCCGTCGTGGCCCCCTCGGGGCTGA
Protein Properties
Number of Residues 372
Molecular Weight 41971.815
Theoretical pI 9.376
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Beta-1,4-galactosyltransferase 2
MSRLLGGTLERVCKAVLLLCLLHFLVAVILYFDVYAQHLAFFSRFSARGPAHALHPAASS
SSSSSNCSRPNATASSSGLPEVPSALPGPTAPTLPPCPDSPPGLVGRLLIEFTSPMPLER
VQRENPGVLMGGRYTPPDCTPAQTVAVIIPFRHREHHLRYWLHYLHPILRRQRLRYGVYV
INQHGEDTFNRAKLLNVGFLEALKEDAAYDCFIFSDVDLVPMDDRNLYRCGDQPRHFAIA
MDKFGFRLPYAGYFGGVSGLSKAQFLRINGFPNEYWGWGGEDDDIFNRISLTGMKISRPD
IRIGRYRMIKHDRDKHNEPNPQRFTKIQNTKLTMKRDGIGSVRYQVLEVSRQPLFTNITV
DIGRPPSWPPRG
GenBank ID Protein 4520136
UniProtKB/Swiss-Prot ID O60909
UniProtKB/Swiss-Prot Entry Name B4GT2_HUMAN
PDB IDs Not Available
GenBank Gene ID AB024434
GeneCard ID B4GALT2
GenAtlas ID B4GALT2
HGNC ID HGNC:925
References
General References Not Available