| Identification |
|---|
| HMDB Protein ID
| CDBP00931 |
| Secondary Accession Numbers
| Not Available |
| Name
| Polypeptide N-acetylgalactosaminyltransferase 11 |
| Description
| Not Available |
| Synonyms
|
- GalNAc-T11
- Polypeptide GalNAc transferase 11
- Protein-UDP acetylgalactosaminyltransferase 11
- UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11
- pp-GaNTase 11
|
| Gene Name
| GALNT11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in polypeptide N-acetylgalactosaminyltransfera |
| Specific Function
| Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward Muc1, Muc4.1, and EA2 than GALNT1. Does not appear to be involved in glycosylation of erythropoietin.
|
| GO Classification
|
| Biological Process |
| O-glycan processing |
| post-translational protein modification |
| Cellular Component |
| integral to membrane |
| Golgi membrane |
| Molecular Function |
| polypeptide N-acetylgalactosaminyltransferase activity |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Mucin type O-Glycan biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7q36.1 |
| SNPs
| GALNT11 |
| Gene Sequence
|
>1827 bp
ATGGGAAGTGTCACAGTTCGGTATTTCTGTTATGGGTGCCTTTTTACATCTGCGACCTGG
ACAGTTTTGCTTTTTGTTTATTTCAACTTCAGTGAAGTGACTCAGCCACTTAAGAATGTG
CCCGTCAAGGGGTCTGGGCCCCACGGACCATCTCCAAAAAAATTCTATCCCCGTTTCACT
CGAGGCCCAAGTCGAGTGCTCGAGCCACAGTTCAAAGCAAACAAAATTGACGATGTGATA
GACAGTCGTGTTGAAGATCCAGAAGAAGGCCACTTGAAATTCTCTTCTGAATTAGGTATG
ATTTTTAATGAACGCGATCAAGAGTTGAGAGACTTGGGCTATCAGAAACATGCTTTTAAT
ATGCTTATCAGTGACCGCTTGGGCTACCACAGAGATGTGCCAGACACAAGGAATGCAGCA
TGTAAAGAAAAGTTCTACCCACCTGACCTGCCAGCTGCTAGTGTTGTTATCTGTTTCTAT
AATGAAGCGTTTTCTGCCTTGCTTCGGACAGTGCACAGTGTCATAGACCGCACGCCAGCA
CACCTGCTTCATGAGATCATCCTTGTGGATGATGATAGTGACTTTGATGATTTGAAAGGA
GAACTAGATGAATATGTCCAAAAATACCTCCCTGGAAAAATTAAAGTCATAAGAAATACA
AAGCGTGAGGGGTTGATTCGAGGGAGAATGATTGGCGCGGCCCACGCGACAGGAGAAGTC
CTTGTGTTCCTGGACAGCCACTGTGAAGTGAATGTGATGTGGCTGCAGCCCTTGCTGGCC
GCCATCCGTGAGGACCGGCACACCGTGGTGTGCCCAGTGATTGACATCATCAGCGCCGAC
ACGCTGGCCTACAGCTCGTCCCCTGTCGTCCGCGGAGGGTTCAACTGGGGACTGCACTTC
AAATGGGATCTTGTCCCCCTTTCTGAGCTAGGACGAGCGGAGGGAGCCACTGCACCAATA
AAGTCACCAACAATGGCTGGAGGTTTGTTTGCCATGAACAGACAGTATTTCCATGAACTT
GGACAGTATGATAGTGGCATGGATATCTGGGGAGGAGAAAATTTGGAAATATCATTTCGG
ATCTGGATGTGTGGCGGTAAGCTCTTCATCATCCCTTGCTCTAGAGTAGGACACATTTTC
CGAAAAAGGCGACCATATGGATCTCCCGAAGGCCAGGACACCATGACACACAACTCTTTG
CGGCTGGCACATGTCTGGTTGGATGAATACAAGGAGCAGTATTTTTCCTTAAGACCTGAC
CTGAAGACGAAAAGCTATGGCAATATCAGTGAGCGTGTGGAACTGAGAAAGAAGTTGGGC
TGTAAATCATTTAAATGGTATTTGGATAATGTATACCCAGAGATGCAGATATCTGGGTCC
CACGCCAAACCCCAACAACCCATTTTTGTCAATAGAGGGCCAAAACGACCCAAAGTCCTT
CAACGTGGAAGGCTCTATCACCTCCAGACCAACAAATGCCTGGTGGCCCAGGGCCGCCCA
AGTCAGAAGGGAGGTCTCGTGGTGCTTAAGGCCTGTGACTACAGTGACCCAAATCAGATC
TGGATCTATAATGAAGAGCATGAATTGGTTTTAAATAGTCTCCTTTGTCTAGATATGTCA
GAGACTCGCTCATCAGACCCGCCACGGCTCATGAAATGCCACGGGTCAGGAGGATCCCAG
CAGTGGACCTTTGGGAAAAACAATCGGCTATACCAGGTGTCGGTTGGACAGTGCCTGAGA
GCAGTGGATCCCCTGGGTCAGAAGGGCTCTGTCGCCATGGCGATCTGCGATGGCTCCTCT
TCACAGCAGTGGCATTTGGAAGGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 608 |
| Molecular Weight
| 68918.365 |
| Theoretical pI
| 8.188 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Polypeptide N-acetylgalactosaminyltransferase 11
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFT
RGPSRVLEPQFKANKIDDVIDSRVEDPEEGHLKFSSELGMIFNERDQELRDLGYQKHAFN
MLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEV
LVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHF
KWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPD
LKTKSYGNISERVELRKKLGCKSFKWYLDNVYPEMQISGSHAKPQQPIFVNRGPKRPKVL
QRGRLYHLQTNKCLVAQGRPSQKGGLVVLKACDYSDPNQIWIYNEEHELVLNSLLCLDMS
ETRSSDPPRLMKCHGSGGSQQWTFGKNNRLYQVSVGQCLRAVDPLGQKGSVAMAICDGSS
SQQWHLEG
|
| External Links |
|---|
| GenBank ID Protein
| 5630076 |
| UniProtKB/Swiss-Prot ID
| Q8NCW6 |
| UniProtKB/Swiss-Prot Entry Name
| GLT11_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AC006017 |
| GeneCard ID
| GALNT11 |
| GenAtlas ID
| GALNT11 |
| HGNC ID
| HGNC:19875 |
| References |
|---|
| General References
| Not Available |