| Identification |
|---|
| HMDB Protein ID
| CDBP00885 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphatidylinositol N-acetylglucosaminyltransferase subunit H |
| Description
| Not Available |
| Synonyms
|
- PIG-H
- Phosphatidylinositol-glycan biosynthesis class H protein
|
| Gene Name
| PIGH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatidylinositol N-acetylglucosaminyltr |
| Specific Function
| Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
|
| GO Classification
|
| Biological Process |
| C-terminal protein lipidation |
| preassembly of GPI anchor in ER membrane |
| Cellular Component |
| endoplasmic reticulum membrane |
| mitochondrion |
| nucleolus |
| glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex |
| Molecular Function |
| phosphatidylinositol N-acetylglucosaminyltransferase activity |
| catalytic activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | glycosylphosphatidylinositol-anchor biosynthesis | Not Available | Not Available | | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| 14q24.1 |
| SNPs
| PIGH |
| Gene Sequence
|
>567 bp
ATGGAGGATGAGCGGAGCTTTTCGGATATCTGCGGCGGCCGCCTGGCGCTGCAGCGCCGC
TACTACTCCCCGTCCTGCCGGGAATTCTGCCTCAGCTGCCCTCGGCTCTCGCTGCGTTCG
CTCACCGCTGTCACCTGCACGGTGTGGCTGGCGGCCTACGGACTCTTCACCCTCTGCGAG
AACAGCATGATCCTCTCTGCTGCCATCTTCATCACCCTCTTAGGTCTGCTTGGTTATCTC
CATTTTGTGAAGATTGATCAGGAGACTCTGTTAATCATTGATTCCCTTGGCATTCAGATG
ACTTCATCTTATGCTTCAGGCAAAGAAAGCACTACCTTCATAGAAATGGGCAAGGTCAAG
GATATTGTCATCAATGAGGCCATTTACATGCAGAAGGTGATTTACTACCTCTGCATCTTA
TTGAAAGATCCAGTGGAACCACATGGGATATCCCAAGTAGTACCCGTCTTCCAGAGTGCC
AAGCCCCGGCTGGACTGCTTGATTGAAGTATACAGGAGCTGCCAGGAGATCCTGGCACAC
CAGAAAGCCACATCAACAAGCCCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 188 |
| Molecular Weight
| 21080.415 |
| Theoretical pI
| 6.724 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
MEDERSFSDICGGRLALQRRYYSPSCREFCLSCPRLSLRSLTAVTCTVWLAAYGLFTLCE
NSMILSAAIFITLLGLLGYLHFVKIDQETLLIIDSLGIQMTSSYASGKESTTFIEMGKVK
DIVINEAIYMQKVIYYLCILLKDPVEPHGISQVVPVFQSAKPRLDCLIEVYRSCQEILAH
QKATSTSP
|
| External Links |
|---|
| GenBank ID Protein
| 189054281 |
| UniProtKB/Swiss-Prot ID
| Q14442 |
| UniProtKB/Swiss-Prot Entry Name
| PIGH_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK314108 |
| GeneCard ID
| PIGH |
| GenAtlas ID
| PIGH |
| HGNC ID
| HGNC:8964 |
| References |
|---|
| General References
| Not Available |