Cannabis Compound Database: Showing Protein Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CDBP00449)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP00449

Secondary Accession Numbers

Not Available

Name

Chondroitin sulfate N-acetylgalactosaminyltransferase 1

Description

Not Available

Synonyms

Beta4GalNAcT-1
Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1
CsGalNAcT-1

Gene Name

CSGALNACT1

Protein Type

Enzyme

Biological Properties

General Function

Involved in transferase activity, transferring hexosyl groups

Specific Function

Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage.

GO Classification

Biological Process
anatomical structure morphogenesis
cell recognition
chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
heparin biosynthetic process
UDP-glucuronate metabolic process
UDP-N-acetylgalactosamine metabolic process
nervous system development
cartilage development
endochondral ossification
dermatan sulfate proteoglycan biosynthetic process
chondroitin sulfate biosynthetic process
extracellular matrix organization
cell proliferation
Cellular Component
Golgi cisterna membrane
integral to Golgi membrane
Component
organelle membrane
golgi cisterna membrane
golgi membrane
membrane
cell part
Function
catalytic activity
transferase activity
transferase activity, transferring hexosyl groups
transferase activity, transferring glycosyl groups
Molecular Function
metal ion binding
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
glucuronosyltransferase activity
glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
peptidoglycan glycosyltransferase activity

Cellular Location

Golgi apparatus
Golgi stack membrane
Single-pass type II membrane protein (Probable)

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	Not Available

Gene Properties

Chromosome Location

Locus

8p21.3

SNPs

CSGALNACT1

Gene Sequence

>1599 bp
ATGATGATGGTTCGCCGGGGGCTGCTTGCGTGGATTTCCCGGGTGGTGGTTTTGCTGGTG
CTCCTCTGCTGTGCTATCTCTGTCCTGTACATGTTGGCCTGCACCCCAAAAGGTGACGAG
GAGCAGCTGGCACTGCCCAGGGCCAACAGCCCCACGGGGAAGGAGGGGTACCAGGCCGTC
CTTCAGGAGTGGGAGGAGCAGCACCGCAACTACGTGAGCAGCCTGAAGCGGCAGATCGCA
CAGCTCAAGGAGGAGCTGCAGGAGAGGAGTGAGCAGCTCAGGAATGGGCAGTACCAAGCC
AGCGATGCTGCTGGCCTGGGTCTGGACAGGAGCCCCCCAGAGAAAACCCAGGCCGACCTC
CTGGCCTTCCTGCACTCGCAGGTGGACAAGGCAGAGGTGAATGCTGGCGTCAAGCTGGCC
ACAGAGTATGCAGCAGTGCCTTTCGATAGCTTTACTCTACAGAAGGTGTACCAGCTGGAG
ACTGGCCTTACCCGCCACCCCGAGGAGAAGCCTGTGAGGAAGGACAAGCGGGATGAGTTG
GTGGAAGCCATTGAATCAGCCTTGGAGACCCTGAACAATCCTGCAGAGAACAGCCCCAAT
CACCGTCCTTACACGGCCTCTGATTTCATAGAAGGGATCTACCGAACAGAAAGGGACAAA
GGGACATTGTATGAGCTCACCTTCAAAGGGGACCACAAACACGAATTCAAACGGCTCATC
TTATTTCGACCATTCAGCCCCATCATGAAAGTGAAAAATGAAAAGCTCAACATGGCCAAC
ACGCTTATCAATGTTATCGTGCCTCTAGCAAAAAGGGTGGACAAGTTCCGGCAGTTCATG
CAGAATTTCAGGGAGATGTGCATTGAGCAGGATGGGAGAGTCCATCTCACTGTTGTTTAC
TTTGGGAAAGAAGAAATAAATGAAGTCAAAGGAATACTTGAAAACACTTCCAAAGCTGCC
AACTTCAGGAACTTTACCTTCATCCAGCTGAATGGAGAATTTTCTCGGGGAAAGGGACTT
GATGTTGGAGCCCGCTTCTGGAAGGGAAGCAACGTCCTTCTCTTTTTCTGTGATGTGGAC
ATCTACTTCACATCTGAATTCCTCAATACGTGTAGGCTGAATACACAGCCAGGGAAGAAG
GTATTTTATCCAGTTCTTTTCAGTCAGTACAATCCTGGCATAATATACGGCCACCATGAT
GCAGTCCCTCCCTTGGAACAGCAGCTGGTCATAAAGAAGGAAACTGGATTTTGGAGAGAC
TTTGGATTTGGGATGACGTGTCAGTATCGGTCAGACTTCATCAATATAGGTGGGTTTGAT
CTGGACATCAAAGGCTGGGGCGGAGAGGATGTGCACCTTTATCGCAAGTATCTCCACAGC
AACCTCATAGTGGTACGGACGCCTGTGCGAGGACTCTTCCACCTCTGGCATGAGAAGCGC
TGCATGGACGAGCTGACCCCCGAGCAGTACAAGATGTGCATGCAGTCCAAGGCCATGAAC
GAGGCATCCCACGGCCAGCTGGGCATGCTGGTGTTCAGGCACGAGATAGAGGCTCACCTT
CGCAAACAGAAACAGAAGACAAGTAGCAAAAAAACATGA

Protein Properties

Number of Residues

532

Molecular Weight

61294.005

Theoretical pI

8.411

Pfam Domain Function

CHGN (PF05679 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Chondroitin sulfate N-acetylgalactosaminyltransferase 1
MMMVRRGLLAWISRVVVLLVLLCCAISVLYMLACTPKGDEEQLALPRANSPTGKEGYQAV
LQEWEEQHRNYVSSLKRQIAQLKEELQERSEQLRNGQYQASDAAGLGLDRSPPEKTQADL
LAFLHSQVDKAEVNAGVKLATEYAAVPFDSFTLQKVYQLETGLTRHPEEKPVRKDKRDEL
VEAIESALETLNSPAENSPNHRPYTASDFIEGIYRTERDKGTLYELTFKGDHKHEFKRLI
LFRPFGPIMKVKNEKLNMANTLINVIVPLAKRVDKFRQFMQNFREMCIEQDGRVHLTVVY
FGKEEINEVKGILENTSKAANFRNFTFIQLNGEFSRGKGLDVGARFWKGSNVLLFFCDVD
IYFTSEFLNTCRLNTQPGKKVFYPVLFSQYNPGIIYGHHDAVPPLEQQLVIKKETGFWRD
FGFGMTCQYRSDFINIGGFDLDIKGWGGEDVHLYRKYLHSNLIVVRTPVRGLFHLWHEKR
CMDELTPEQYKMCMQSKAMNEASHGQLGMLVFRHEIEAHLRKQKQKTSSKKT

External Links

GenBank ID Protein

19352192

UniProtKB/Swiss-Prot ID

Q8TDX6

UniProtKB/Swiss-Prot Entry Name

CGAT1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AB071403

GeneCard ID