Identification |
HMDB Protein ID
| CDBP00970 |
Secondary Accession Numbers
| Not Available |
Name
| Beta-1,4-galactosyltransferase 4 |
Description
| Not Available |
Synonyms
|
- Beta-1,4-GalTase 4
- Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase
- Beta4Gal-T4
- N-acetyllactosamine synthase
- Nal synthase
- UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 4
- UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 4
- b4Gal-T4
|
Gene Name
| B4GALT4 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in transferase activity, transferring glycosyl groups |
Specific Function
| Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
|
GO Classification
|
Biological Process |
keratan sulfate biosynthetic process |
post-translational protein modification |
protein N-linked glycosylation via asparagine |
membrane lipid metabolic process |
Cellular Component |
Golgi cisterna membrane |
integral to membrane |
Golgi membrane |
Function |
catalytic activity |
transferase activity |
transferase activity, transferring glycosyl groups |
Molecular Function |
N-acetyllactosamine synthase activity |
metal ion binding |
galactosyltransferase activity |
Process |
primary metabolic process |
carbohydrate metabolic process |
metabolic process |
|
Cellular Location
|
- Single-pass type II membrane protein
- Golgi apparatus
- Golgi stack membrane
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | protein glycosylation | Not Available | Not Available | Glycosaminoglycan biosynthesis - keratan sulfate | Not Available | ![Map00533](https://www.genome.jp/kegg/misc/thumbnail/map00533.gif) | Glycosphingolipid biosynthesis - lacto and neolacto series | Not Available | ![Map00601](https://www.genome.jp/kegg/misc/thumbnail/map00601.gif) |
|
Gene Properties |
Chromosome Location
| 3 |
Locus
| 3q13.3 |
SNPs
| B4GALT4 |
Gene Sequence
|
>1035 bp
ATGGGCTTCAACCTGACTTTCCACCTTTCCTACAAATTCCGATTACTGTTGCTGTTGACT
TTGTGCCTGACAGTGGTTGGGTGGGCCACCAGTAACTACTTCGTGGGTGCCATTCAAGAG
ATTCCTAAAGCAAAGGAGTTCATGGCTAATTTCCATAAGACCCTCATTTTGGGGAAGGGA
AAAACTCTGACTAATGAAGCATCCACGAAGAAGGTAGAACTTGACAACTGCCCTTCTGTG
TCTCCTTACCTCAGAGGCCAGAGCAAGCTCATTTTCAAACCAGATCTCACTTTGGAAGAG
GTACAGGCAGAAAATCCCAAAGTGTCCAGAGGCCGGTATCGCCCTCAGGAATGTAAAGCT
TTACAGAGGGTCGCCATCCTCGTTCCCCACCGGAACAGAGAGAAACACCTGATGTACCTG
CTGGAACATCTGCATCCCTTCCTGCAGAGGCAGCAGCTGGATTATGGCATCTACGTCATC
CACCAGGCTGAAGGTAAAAAGTTTAATCGAGCCAAACTCTTGAATGTGGGCTATCTAGAA
GCCCTCAAGGAAGAAAATTGGGACTGCTTTATATTCCACGATGTGGACCTGGTACCCGAG
AATGACTTTAACCTTTACAAGTGTGAGGAGCATCCCAAGCATCTGGTGGTTGGCAGGAAC
AGCACTGGGTACAGGTTACGTTACAGTGGATATTTTGGGGGTGTTACTGCCCTAAGCAGA
GAGCAGTTTTTCAAGGTGAATGGATTCTCTAACAACTACTGGGGATGGGGAGGCGAAGAC
GATGACCTCAGACTCAGGGTTGAGCTCCAAAGAATGAAAATTTCCCGGCCCCTGCCTGAA
GTGGGTAAATATACAATGGTCTTCCACACTAGAGACAAAGGCAATGAGGTGAACGCAGAA
CGGATGAAGCTCTTACACCAAGTGTCACGAGTCTGGAGAACAGATGGGTTGAGTAGTTGT
TCTTATAAATTAGTATCTGTGGAACACAATCCTTTATATATCAACATCACAGTGGATTTC
TGGTTTGGTGCATGA
|
Protein Properties |
Number of Residues
| 344 |
Molecular Weight
| 40040.865 |
Theoretical pI
| 9.074 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Beta-1,4-galactosyltransferase 4
MGFNLTFHLSYKFRLLLLLTLCLTVVGWATSNYFVGAIQEIPKAKEFMANFHKTLILGKG
KTLTNEASTKKVELDNCPSVSPYLRGQSKLIFKPDLTLEEVQAENPKVSRGRYRPQECKA
LQRVAILVPHRNREKHLMYLLEHLHPFLQRQQLDYGIYVIHQAEGKKFNRAKLLNVGYLE
ALKEENWDCFIFHDVDLVPENDFNLYKCEEHPKHLVVGRNSTGYRLRYSGYFGGVTALSR
EQFFKVNGFSNNYWGWGGEDDDLRLRVELQRMKISRPLPEVGKYTMVFHTRDKGNEVNAE
RMKLLHQVSRVWRTDGLSSCSYKLVSVEHNPLYINITVDFWFGA
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| O60513 |
UniProtKB/Swiss-Prot Entry Name
| B4GT4_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF038662 |
GeneCard ID
| B4GALT4 |
GenAtlas ID
| B4GALT4 |
HGNC ID
| HGNC:927 |
References |
General References
| Not Available |