| Identification |
|---|
| HMDB Protein ID
| CDBP00364 |
| Secondary Accession Numbers
| Not Available |
| Name
| Alpha-lactalbumin |
| Description
| Not Available |
| Synonyms
|
- Lactose synthase B protein
- Lysozyme-like protein 7
|
| Gene Name
| LALBA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in lactose synthase activity |
| Specific Function
| Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
|
| GO Classification
|
| Biological Process |
| signal transduction |
| cell-cell signaling |
| lactose biosynthetic process |
| defense response to bacterium |
| induction of apoptosis |
| Cellular Component |
| extracellular space |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| transferase activity |
| udp-glycosyltransferase activity |
| udp-galactosyltransferase activity |
| lactose synthase activity |
| transferase activity, transferring glycosyl groups |
| calcium ion binding |
| Molecular Function |
| lactose synthase activity |
| calcium ion binding |
| Process |
| carbohydrate metabolic process |
| oligosaccharide metabolic process |
| disaccharide metabolic process |
| lactose metabolic process |
| lactose biosynthetic process |
| metabolic process |
| primary metabolic process |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Lactose Synthesis |    | Not Available | | Congenital disorder of glycosylation CDG-IId |    | Not Available | | GLUT-1 deficiency syndrome |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| LALBA |
| Gene Sequence
|
>429 bp
ATGAGGTTCTTTGTCCCTCTGTTCCTGGTGGGCATCCTGTTCCCTGCCATCCTGGCCAAG
CAATTCACAAAATGTGAGCTGTCCCAGCTGCTGAAAGACATAGATGGTTATGGAGGCATC
GCTTTGCCTGAATTGATCTGTACCATGTTTCACACCAGTGGTTATGACACACAAGCCATA
GTTGAAAACAATGAAAGCACGGAATATGGACTCTTCCAGATCAGTAATAAGCTTTGGTGC
AAGAGCAGCCAGGTCCCTCAGTCAAGGAACATCTGTGACATCTCCTGTGACAAGTTCCTG
GATGATGACATTACTGATGACATAATGTGTGCCAAGAAGATCCTGGATATTAAAGGAATT
GACTACTGGTTGGCCCATAAAGCCCTCTGCACTGAGAAGCTGGAACAGTGGCTTTGTGAG
AAGTTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 142 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alpha-lactalbumin
MRFFVPLFLVGILFPAILAKQFTKCELSQLLKDIDGYGGIALPELICTMFHTSGYDTQAI
VENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCDKFLDDDITDDIMCAKKILDIKGI
DYWLAHKALCTEKLEQWLCEKL
|
| External Links |
|---|
| GenBank ID Protein
| 307104 |
| UniProtKB/Swiss-Prot ID
| P00709 |
| UniProtKB/Swiss-Prot Entry Name
| LALBA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| J00270 |
| GeneCard ID
| LALBA |
| GenAtlas ID
| LALBA |
| HGNC ID
| HGNC:6480 |
| References |
|---|
| General References
| Not Available |