Identification |
HMDB Protein ID
| CDBP00470 |
Secondary Accession Numbers
| Not Available |
Name
| UDP-glucuronosyltransferase 2B17 |
Description
| Not Available |
Synonyms
|
- C19-steroid-specific UDP-glucuronosyltransferase
- C19-steroid-specific UDPGT
- UDPGT 2B17
|
Gene Name
| UGT2B17 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in transferase activity, transferring hexosyl groups |
Specific Function
| UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).
|
GO Classification
|
Biological Process |
steroid metabolic process |
Cellular Component |
endoplasmic reticulum membrane |
membrane |
integral to membrane |
Function |
catalytic activity |
transferase activity |
transferase activity, transferring hexosyl groups |
transferase activity, transferring glycosyl groups |
Molecular Function |
glucuronosyltransferase activity |
Process |
metabolic process |
|
Cellular Location
|
- Endoplasmic reticulum membrane
- Microsome membrane
- Single-pass membrane protein (Potential)
- Single-pass membrane protein (Potential)
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Pentose and glucuronate interconversions | Not Available | ![Map00040](https://www.genome.jp/kegg/misc/thumbnail/map00040.gif) | Ascorbate and aldarate metabolism | Not Available | ![Map00053](https://www.genome.jp/kegg/misc/thumbnail/map00053.gif) | Steroid hormone biosynthesis | Not Available | ![Map00140](https://www.genome.jp/kegg/misc/thumbnail/map00140.gif) | Porphyrin and chlorophyll metabolism | Not Available | ![Map00860](https://www.genome.jp/kegg/misc/thumbnail/map00860.gif) | Metabolism of xenobiotics by cytochrome P450 | Not Available | ![Map00980](https://www.genome.jp/kegg/misc/thumbnail/map00980.gif) |
|
Gene Properties |
Chromosome Location
| 4 |
Locus
| 4q13 |
SNPs
| UGT2B17 |
Gene Sequence
|
>1593 bp
ATGTCTCTGAAATGGATGTCAGTCTTTCTGCTGATGCAGCTCAGTTGTTACTTTAGCTCT
GGGAGTTGTGGAAAGGTGCTGGTGTGGCCCACAGAATACAGCCATTGGATAAATATGAAG
ACAATCCTGGAAGAGCTTGTTCAGAGGGGTCATGAGGTGATTGTGTTGACATCTTCGGCT
TCTATTCTTGTCAATGCCAGTAAATCATCTGCTATTAAATTAGAAGTTTATCCTACATCT
TTAACTAAAAATGATTTGGAAGATTTTTTTATGAAAATGTTCGATAGATGGACATATAGT
ATTTCAAAAAATACATTTTGGTCATATTTTTCACAACTACAAGAATTGTGTTGGGAATAT
TCTGACTATAATATAAAGCTCTGTGAAGATGCAGTTTTGAACAAGAAACTTATGAGAAAA
CTACAAGAGTCAAAATTTGATGTCCTTCTGGCAGATGCCGTTAATCCCTGTGGTGAGCTG
CTGGCTGAACTACTTAACATACCCTTTCTGTACAGTCTCCGCTTCTCTGTTGGCTACACA
GTTGAGAAGAATGGTGGAGGATTTCTGTTCCCTCCTTCCTATGTACCTGTTGTTATGTCA
GAATTAAGTGATCAAATGATTTTCATGGAGAGGATAAAAAATATGATATATATGCTTTAT
TTTGACTTTTGGTTTCAAGCATATGATCTGAAGAAGTGGGACCAGTTTTATAGTGAAGTT
CTAGGAAGACCCACTACATTATTTGAGACAATGGGGAAAGCTGAAATGTGGCTCATTCGA
ACCTATTGGGATTTTGAATTTCCTCGCCCATTCTTACCAAATGTTGATTTTGTTGGAGGA
CTTCACTGTAAACCAGCCAAACCCTTGCCTAAGGAAATGGAAGAGTTTGTGCAGAGCTCT
GGAGAAAATGGTATTGTGGTGTTTTCTCTGGGGTCGATGATCAGTAACATGTCAGAAGAA
AGTGCCAACATGATTGCATCAGCCCTTGCCCAGATCCCACAAAAGGTTCTATGGAGATTT
GATGGCAAGAAGCCAAATACTTTAGGTTCCAATACTCGACTGTATAAGTGGTTACCCCAG
AATGACCTTCTTGGTCATCCCAAAACCAAAGCTTTTATAACTCATGGTGGAACCAATGGC
ATCTATGAGGCGATCTACCATGGGATCCCTATGGTGGGCATTCCCTTGTTTGCGGATCAA
CATGATAACATTGCTCACATGAAAGCCAAGGGAGCAGCCCTCAGTGTGGACATCAGGACC
ATGTCAAGTAGAGATTTGCTCAATGCATTGAAGTCAGTCATTAATGACCCTATCTATAAA
GAGAATATCATGAAATTATCAAGAATTCATCATGATCAACCGGTGAAGCCCCTGGATCGA
GCAGTCTTCTGGATTGAGTTTGTCATGCGCCATAAAGGAGCCAAGCACCTTCGGGTCGCA
GCCCACAACCTCACCTGGATCCAGTACCACTCTTTGGATGTGATAGCATTCCTGCTGGCC
TGCGTGGCAACTATGATATTTATGATCACAAAATGTTGCCTGTTTTGTTTCCGAAAGCTT
GCCAAAACAGGAAAGAAGAAGAAAAGGGATTAG
|
Protein Properties |
Number of Residues
| 530 |
Molecular Weight
| 61094.915 |
Theoretical pI
| 8.544 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>UDP-glucuronosyltransferase 2B17
MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSA
SILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEY
SDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYT
VEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEV
LGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSS
GENGIVVFSLGSMISNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQ
NDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRT
MSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVA
AHNLTWIQYHSLDVIAFLLACVATMIFMITKCCLFCFRKLAKTGKKKKRD
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| O75795 |
UniProtKB/Swiss-Prot Entry Name
| UDB17_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| U59209 |
GeneCard ID
| UGT2B17 |
GenAtlas ID
| UGT2B17 |
HGNC ID
| HGNC:12547 |
References |
General References
| Not Available |