| Identification |
|---|
| HMDB Protein ID
| CDBP00887 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphatidylinositol N-acetylglucosaminyltransferase subunit C |
| Description
| Not Available |
| Synonyms
|
- PIG-C
- Phosphatidylinositol-glycan biosynthesis class C protein
|
| Gene Name
| PIGC |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatidylinositol N-acetylglucosaminyltransferase activity |
| Specific Function
| Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
|
| GO Classification
|
| Biological Process |
| C-terminal protein lipidation |
| preassembly of GPI anchor in ER membrane |
| Cellular Component |
| endoplasmic reticulum membrane |
| glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex |
| integral to membrane |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| catalytic activity |
| transferase activity |
| acetylglucosaminyltransferase activity |
| phosphatidylinositol n-acetylglucosaminyltransferase activity |
| udp-glycosyltransferase activity |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| phosphatidylinositol N-acetylglucosaminyltransferase activity |
| catalytic activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein amino acid lipidation |
| gpi anchor biosynthetic process |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
- Multi-pass membrane protein (Potential)
- Endoplasmic reticulum membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | glycosylphosphatidylinositol-anchor biosynthesis | Not Available | Not Available | | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q23-q25 |
| SNPs
| PIGC |
| Gene Sequence
|
>894 bp
ATGTATGCTCAACCTGTGACTAACACCAAGGAGGTCAAGTGGCAGAAGGTCTTGTATGAG
CGACAGCCCTTTCCTGATAACTATGTGGACCGGCGATTCCTGGAAGAGCTCCGGAAAAAC
ATCCATGCTCGGAAATACCAATATTGGGCTGTGGTATTTGAGTCCAGTGTGGTGATCCAG
CAGCTGTGCAGTGTTTGTGTTTTTGTGGTTATCTGGTGGTATATGGATGAGGGTCTTCTG
GCCCCCCATTGGCTTTTAGGGACTGGCCTGGCTTCTTCACTGATTGGGTATGTTTTGTTT
GATCTCATTGATGGAGGTGAAGGGCGGAAGAAGAGTGGGCAGACCCGGTGGGCTGACCTG
AAGAGTGCCCTAGTCTTCATTACTTTCACTTATGGGTTTTCACCAGTGCTGAAGACCCTT
ACAGAGTCTGTCAGCACTGACACCATCTATGCCATGTCAGTCTTCATGCTGTTAGGCCAT
CTCATCTTTTTTGACTATGGTGCCAATGCTGCCATTGTATCCAGCACACTATCCTTGAAC
ATGGCCATCTTTGCTTCTGTATGCTTGGCATCACGTCTTCCCCGGTCCCTGCATGCCTTC
ATCATGGTGACATTTGCCATTCAGATTTTTGCCCTGTGGCCCATGTTGCAGAAGAAACTA
AAGGCATGTACTCCCCGGAGCTATGTGGGGGTCACACTGCTTTTTGCATTTTCAGCCGTG
GGAGGCCTACTGTCCATTAGTGCTGTGGGAGCCGTACTCTTTGCCCTTCTGCTGATGTCT
ATCTCATGTCTGTGTTCATTCTACCTCATTCGCTTGCAGCTTTTTAAAGAAAACATTCAT
GGGCCTTGGGATGAAGCTGAAATCAAGGAAGACTTGTCCAGGTTCCTCAGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 297 |
| Molecular Weight
| 33582.18 |
| Theoretical pI
| 8.41 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
MYAQPVTNTKEVKWQKVLYERQPFPDNYVDRRFLEELRKNIHARKYQYWAVVFESSVVIQ
QLCSVCVFVVIWWYMDEGLLAPHWLLGTGLASSLIGYVLFDLIDGGEGRKKSGQTRWADL
KSALVFITFTYGFSPVLKTLTESVSTDTIYAMSVFMLLGHLIFFDYGANAAIVSSTLSLN
MAIFASVCLASRLPRSLHAFIMVTFAIQIFALWPMLQKKLKACTPRSYVGVTLLFAFSAV
GGLLSISAVGAVLFALLLMSISCLCPFYLIRLQLFKENIHGPWDEAEIKEDLSRFLS
|
| External Links |
|---|
| GenBank ID Protein
| 2547042 |
| UniProtKB/Swiss-Prot ID
| Q92535 |
| UniProtKB/Swiss-Prot Entry Name
| PIGC_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB000360 |
| GeneCard ID
| PIGC |
| GenAtlas ID
| PIGC |
| HGNC ID
| HGNC:8960 |
| References |
|---|
| General References
| Not Available |