| Identification |
|---|
| HMDB Protein ID
| CDBP02137 |
| Secondary Accession Numbers
| Not Available |
| Name
| N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform B |
| Description
| Not Available |
| Synonyms
|
- I-branching enzyme
- IGNT
- N-acetylglucosaminyltransferase
|
| Gene Name
| GCNT2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acetylglucosaminyltransferase activity |
| Specific Function
| Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C.
|
| GO Classification
|
| Biological Process |
| multicellular organismal development |
| glycosaminoglycan biosynthetic process |
| protein glycosylation |
| Cellular Component |
| membrane |
| integral to membrane |
| Golgi membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| transferase activity |
| acetylglucosaminyltransferase activity |
| udp-glycosyltransferase activity |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | Glycosphingolipid biosynthesis - lacto and neolacto series | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6p24.2 |
| SNPs
| GCNT2 |
| Gene Sequence
|
>1203 bp
ATGCCTTTATCAATGCGTTACCTCTTCATAATTTCTGTCTCTAGTGTAATTATTTTTATC
GTCTTCTCTGTGTTCAATTTTGGGGGAGATCCAAGCTTCCAAAGGCTAAATATCTCAGAC
CCTTTGAGGCTGACTCAAGTTTGCACATCTTTTATCAATGGAAAAACACGTTTCCTGTGG
AAAAACAAACTAATGATCCATGAGAAGTCTTCTTGCAAGGAATACTTGACCCAGAGCCAC
TACATCACAGCCCCTTTATCTAAGGAAGAAGCTGACTTTCCCTTGGCATATATAATGGTC
ATCCATCATCACTTTGACACCTTTGCAAGGCTCTTCAGGGCTATTTACATGCCCCAAAAT
ATCTACTGTGTTCATGTGGATGAAAAAGCAACAACTGAATTTAAAGATGCGGTAGAGCAA
CTATTAAGCTGCTTCCCAAACGCTTTTCTGGCTTCCAAGATGGAACCCGTTGTCTATGGA
GGGATCTCCAGGCTCCAGGCTGACCTGAACTGCATCAGAGATCTTTCTGCCTTCGAGGTC
TCATGGAAGTACGTTATCAACACCTGTGGGCAAGACTTCCCCCTGAAAACCAACAAGGAA
ATAGTTCAGTATCTGAAAGGATTTAAAGGTAAAAATATCACCCCAGGGGTGCTGCCCCCA
GCTCATGCAATTGGACGGACTAAATATGTCCACCAAGAGCACCTGGGCAAAGAGCTTTCC
TATGTGATAAGAACAACAGCGTTGAAACCGCCTCCCCCCCATAATCTCACAATTTACTTT
GGCTCTGCCTATGTGGCTCTATCAAGAGAGTTTGCCAACTTTGTTCTGCATGACCCACGG
GCTGTTGATTTGCTCCAGTGGTCCAAGGACACTTTCAGTCCTGATGAGCATTTCTGGGTG
ACACTCAATAGGATTCCAGGTGTTCCTGGCTCTATGCCAAATGCATCCTGGACTGGAAAC
CTCAGAGCTATAAAGTGGAGTGACATGGAAGACAGACACGGAGGCTGCCACGGCCACTAT
GTACATGGTATTTGTATCTATGGAAACGGAGACTTAAAGTGGCTGGTTAATTCACCAAGC
CTGTTTGCTAACAAGTTTGAGCTTAATACCTACCCCCTTACTGTGGAATGCCTAGAACTG
AGGCATCGCGAAAGAACCCTCAATCAGAGTGAAACTGCGATACAACCCAGCTGGTATTTT
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 400 |
| Molecular Weight
| 45854.405 |
| Theoretical pI
| 8.215 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform B
MPLSMRYLFIISVSSVIIFIVFSVFNFGGDPSFQRLNISDPLRLTQVCTSFINGKTRFLW
KNKLMIHEKSSCKEYLTQSHYITAPLSKEEADFPLAYIMVIHHHFDTFARLFRAIYMPQN
IYCVHVDEKATTEFKDAVEQLLSCFPNAFLASKMEPVVYGGISRLQADLNCIRDLSAFEV
SWKYVINTCGQDFPLKTNKEIVQYLKGFKGKNITPGVLPPAHAIGRTKYVHQEHLGKELS
YVIRTTALKPPPPHNLTIYFGSAYVALSREFANFVLHDPRAVDLLQWSKDTFSPDEHFWV
TLNRIPGVPGSMPNASWTGNLRAIKWSDMEDRHGGCHGHYVHGICIYGNGDLKWLVNSPS
LFANKFELNTYPLTVECLELRHRERTLNQSETAIQPSWYF
|
| External Links |
|---|
| GenBank ID Protein
| 21667009 |
| UniProtKB/Swiss-Prot ID
| Q06430 |
| UniProtKB/Swiss-Prot Entry Name
| GNT2B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF458025 |
| GeneCard ID
| GCNT2 |
| GenAtlas ID
| GCNT2 |
| HGNC ID
| HGNC:4204 |
| References |
|---|
| General References
| Not Available |