Cannabis Compound Database: Showing Compound Card for S-Adenosylhomocysteine (CDB004872)

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Record Information

Version

1.0

Created at

2020-04-17 18:45:30 UTC

Updated at

2020-12-07 19:11:09 UTC

CannabisDB ID

CDB004872

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

S-Adenosylhomocysteine

Description

S-Adenosylhomocysteine, also known as adenosyl-homo-cys or adohcy, belongs to the class of organic compounds known as gamma butyrolactones. Gamma butyrolactones are compounds containing a gamma butyrolactone moiety, which consists of an aliphatic five-member ring with four carbon atoms, one oxygen atom, and bears a ketone group on the carbon adjacent to the oxygen atom. An organic sulfide that is the S-adenosyl derivative of L-homocysteine. S-Adenosylhomocysteine is a very strong basic compound (based on its pKa). S-Adenosylhomocysteine exists in all living species, ranging from bacteria to humans. Outside of the human body, S-Adenosylhomocysteine has been detected, but not quantified in, several different foods, such as arrowhead, guava, purslanes, kiwis, and gooseberries. This could make S-adenosylhomocysteine a potential biomarker for the consumption of these foods. S-Adenosylhomocysteine is a potentially toxic compound. S-Adenosylhomocysteine is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2S)-2-Amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoic acid	ChEBI
2-S-Adenosyl-L-homocysteine	ChEBI
Adenosyl-L-homocysteine	ChEBI
Adenosylhomocysteine	ChEBI
AdoHcy	ChEBI
S-(5'-Adenosyl)-L-homocysteine	ChEBI
S-[1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl]-L-homocysteine	ChEBI
SAH	ChEBI
(2S)-2-Amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoate	Generator
(2S)-2-Amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulphanyl)butanoate	Generator
(2S)-2-Amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulphanyl)butanoic acid	Generator
S-[1-(Adenin-9-yl)-1,5-dideoxy-b-D-ribofuranos-5-yl]-L-homocysteine	Generator
S-[1-(Adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl]-L-homocysteine	Generator
(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine	HMDB
5'-Deoxy-S-adenosyl-L-homocysteine	HMDB
5'-S-(3-Amino-3-carboxypropyl)-5'-thio-L-adenosine	HMDB
Adenosyl-homo-cys	HMDB
Adenosylhomo-cys	HMDB
Formycinylhomocysteine	HMDB
L-5'-S-(3-Amino-3-carboxypropyl)-5'-thior-adenosine	HMDB
L-S-Adenosyl-homocysteine	HMDB
L-S-Adenosylhomocysteine	HMDB
S-(5'-Deoxyadenosin-5'-yl)-L-homocysteine	HMDB
S-(5'-Deoxyadenosine-5')-L-homocysteine	HMDB
S-Adenosyl-homocysteine	HMDB
S-Adenosyl-L-homocysteine	HMDB
Adenosylhomocysteine, S	HMDB
S Adenosylhomocysteine	HMDB

Chemical Formula

C₁₄H₂₀N₆O₅S

Average Molecular Weight

384.41

Monoisotopic Molecular Weight

384.1216

IUPAC Name

(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acid

Traditional Name

S-adenosyl-L-homocysteine

CAS Registry Number

979-92-0

SMILES

N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C(O)=O

InChI Identifier

InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1

InChI Key

ZJUKTBDSGOFHSH-WFMPWKQPSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as gamma butyrolactones. Gamma butyrolactones are compounds containing a gamma butyrolactone moiety, which consists of an aliphatic five-member ring with four carbon atoms, one oxygen atom, and bears a ketone group on the carbon adjacent to the oxygen atom.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Lactones

Sub Class

Gamma butyrolactones

Direct Parent

Gamma butyrolactones

Alternative Parents

Substituents

Gamma butyrolactone
Tetrahydrofuran
Secondary alcohol
Carboxylic acid ester
1,2-diol
Oxacycle
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

diol (CHEBI:71176 )
butan-4-olide (CHEBI:71176 )

Ontology

Physiological effect

Health effect:

Health condition:

Neurodegenerative disease

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Plant:

Biological location:

Role

Indirect biological role:

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	209 - 211 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-2.4	ALOGPS
logP	-4	ChemAxon
logS	-2	ALOGPS
pKa (Strongest Acidic)	1.81	ChemAxon
pKa (Strongest Basic)	9.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	10	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	182.63 Å²	ChemAxon
Rotatable Bond Count	7	ChemAxon
Refractivity	92.72 m³·mol⁻¹	ChemAxon
Polarizability	38.41 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	S-Adenosylhomocysteine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0a6u-9853000000-441f171739659ea2b5f6	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, 3 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-004r-7096060000-d32383fe3b85ef1b9032	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_1_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_2_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_2_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_2_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_2_6, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_2_7, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_2_8, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_2_9, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_2_10, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_2_11, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_2_12, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_3_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_3_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_3_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	S-Adenosylhomocysteine, TMS_3_5, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0319020200-859d659a39a790a582f1	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a4i-0900000000-53acf4e10681047da062	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0910000000-5896502e31d66786e12a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0009000000-01ea51599f8d30dec7fe	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0409000100-2de58945ab0dfa81f099	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a4i-1900000000-a640f1a0bafd33afdd2d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0910000000-5f685035af9b243ccff2	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0009000000-8d01fd0969e47d3bcc5c	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-001i-0902000000-c6c0d5529cf011d89f7b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , negative	splash10-0a4i-0900000000-53acf4e10681047da062	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , negative	splash10-001i-0910000000-5896502e31d66786e12a	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , negative	splash10-001i-0009000000-01ea51599f8d30dec7fe	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , negative	splash10-0a4i-1900000000-a640f1a0bafd33afdd2d	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , negative	splash10-001i-0910000000-6da47cc70ea7d7eb41f1	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT , negative	splash10-001i-0009000000-8d01fd0969e47d3bcc5c	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-001i-0902000000-c6c0d5529cf011d89f7b	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Negative	splash10-001i-0900000000-978dc4fcc4643522e8ef	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0006-0943000000-80fa5c7d919e1085bc5d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-0900000000-3f143852503952daa0a8	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-03di-0900000000-23694a4b657a3478ad91	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udr-0980000000-a8f61dcdc8693e2725f5	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00kf-0974000000-b3f3632635b2847bf4d2	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-0900000000-188a77c79aaefae8a184	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-b848c20d743785117445	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udr-0980000000-64b7b303fc07300e0782	2012-08-31	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, 100%_DMSO, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, 100%_DMSO, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Betaine Metabolism
Methionine Metabolism
Carnitine Synthesis		Not Available
Glycine and Serine Metabolism
Arginine and Proline Metabolism

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Phosphatidylethanolamine N-methyltransferase	PEMT	17p11.2	Q9UBM1	details
Acetylserotonin O-methyltransferase	ASMT	Xp22.3 or Yp11.3	P46597	details
Catechol O-methyltransferase	COMT	22q11.21	P21964	details
Histone-lysine N-methyltransferase, H3 lysine-79 specific	DOT1L	19p13.3	Q8TEK3	details
Glycine N-methyltransferase	GNMT	6p12	Q14749	details
Histone-lysine N-methyltransferase SETD7	SETD7	4q28	Q8WTS6	details
Phenylethanolamine N-methyltransferase	PNMT	17q	P11086	details
Diphthine synthase	DPH5	1p21.2	Q9H2P9	details
Arsenite methyltransferase	AS3MT	10q24.32	Q9HBK9	details
Mitochondrial tRNA-specific 2-thiouridylase 1	TRMU	22q13	O75648	details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	NSD1	5q35	Q96L73	details
Histone-lysine N-methyltransferase SETDB1	SETDB1	1q21	Q15047	details
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	PCMT1	6q24-q25	P22061	details
Protein-S-isoprenylcysteine O-methyltransferase	ICMT	1p36.21	O60725	details
Indolethylamine N-methyltransferase	INMT	7p14.3	O95050	details
DNA (cytosine-5)-methyltransferase 3A	DNMT3A	2p23	Q9Y6K1	details
Hexaprenyldihydroxybenzoate methyltransferase, mitochondrial	COQ3	6q16.2	Q9NZJ6	details
Histone-lysine N-methyltransferase EHMT2	EHMT2	6p21.31	Q96KQ7	details
Methionine synthase reductase	MTRR	5p15.31	Q9UBK8	details
Histone-lysine N-methyltransferase SUV39H1	SUV39H1	Xp11.23	O43463	details
Nicotinamide N-methyltransferase	NNMT	11q23.1	P40261	details
Histone-lysine N-methyltransferase SUV39H2	SUV39H2	10p13	Q9H5I1	details
Histone-lysine N-methyltransferase EHMT1	EHMT1	9q34.3	Q9H9B1	details
Guanidinoacetate N-methyltransferase	GAMT	19p13.3	Q14353	details
Histamine N-methyltransferase	HNMT	2q22.1	P50135	details
Thiopurine S-methyltransferase	TPMT	6p22.3	P51580	details
N6-adenosine-methyltransferase 70 kDa subunit	METTL3	14q11.1	Q86U44	details
Putative adenosylhomocysteinase 3	AHCYL2	7q32.1	Q96HN2	details
Adenosylhomocysteinase	AHCY	20q11.22	P23526	details
Putative adenosylhomocysteinase 2	AHCYL1	1p13.2	O43865	details
Protein arginine N-methyltransferase 5	PRMT5	14q11.2	O14744	details
Histone-lysine N-methyltransferase SETD1A	SETD1A	16p11.2	O15047	details
Histone-lysine N-methyltransferase MLL	MLL	11q23	Q03164	details
DNA (cytosine-5)-methyltransferase 3B	DNMT3B	20q11.2	Q9UBC3	details
tRNA (cytosine(38)-C(5))-methyltransferase	TRDMT1	10p15.1	O14717	details
N-lysine methyltransferase SETD8	SETD8	12q24.31	Q9NQR1	details
Histone-lysine N-methyltransferase MLL3	MLL3	7q36.1	Q8NEZ4	details
DNA (cytosine-5)-methyltransferase 1	DNMT1	19p13.2	P26358	details
Histone-lysine N-methyltransferase SETDB2	SETDB2	13q14	Q96T68	details
tRNA (cytosine(34)-C(5))-methyltransferase	NSUN2	5p15.31	Q08J23	details
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial	COQ5	12q24.31	Q5HYK3	details
Histone-lysine N-methyltransferase ASH1L	ASH1L	1q22	Q9NR48	details
Histone-arginine methyltransferase CARM1	CARM1	19p13.2	Q86X55	details
Histone-lysine N-methyltransferase EZH2	EZH2	7q35-q36	Q15910	details
mRNA cap guanine-N7 methyltransferase	RNMT	18p11.21	O43148	details
Histone-lysine N-methyltransferase MLL2	MLL2	12q13.12	O14686	details
Histone-lysine N-methyltransferase MLL4	WBP7	19q13.1	Q9UMN6	details
Histone-lysine N-methyltransferase MLL5	MLL5	7q22.1	Q8IZD2	details
Histone-lysine N-methyltransferase NSD2	WHSC1	4p16.3	O96028	details
Histone-lysine N-methyltransferase NSD3	WHSC1L1	8p11.2	Q9BZ95	details
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase	FTSJ1	Xp11.23	Q9UET6	details
Putative ribosomal RNA methyltransferase 2	FTSJ2	7p22	Q9UI43	details
Histone-lysine N-methyltransferase SETD1B	SETD1B	12q24.31	Q9UPS6	details
Histone-lysine N-methyltransferase SETD2	SETD2	3p21.31	Q9BYW2	details
Histone-lysine N-methyltransferase SETMAR	SETMAR	3p26.1	Q53H47	details
Histone-lysine N-methyltransferase SMYD3	SMYD3	1q44	Q9H7B4	details
Histone-lysine N-methyltransferase SUV420H1	SUV420H1	11q13.2	Q4FZB7	details
Histone-lysine N-methyltransferase SUV420H2	SUV420H2	19q13.42	Q86Y97	details
tRNA (guanine(26)-N(2))-dimethyltransferase	TRMT1	19p13.2	Q9NXH9	details
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A	TRMT61A	14q32	Q96FX7	details
tRNA (guanine-N(7)-)-methyltransferase	METTL1	12q13	Q9UBP6	details
tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial	TRMT61B	2p23.2	Q9BVS5	details
tRNA (guanine(37)-N1)-methyltransferase	TRMT5	14q23.1	Q32P41	details
Transmembrane O-methyltransferase	LRTOMT	11q13.4	Q8WZ04	details
DNA (cytosine-5)-methyltransferase 3-like	DNMT3L		Q9UJW3	details
Histone-lysine N-methyltransferase EZH1	EZH1	17q21.1-q21.3	Q92800	details
Leucine carboxyl methyltransferase 1	LCMT1	16p12.1	Q9UIC8	details
tRNA (uracil(54)-C(5))-methyltransferase homolog	TRMT2B	Xq22.1	Q96GJ1	details
Protein arginine N-methyltransferase 1	PRMT1	19q13.3	Q99873	details
Protein arginine N-methyltransferase 2	PRMT2	21q22.3	P55345	details
Protein arginine N-methyltransferase 6	PRMT6	1p13.3	Q96LA8	details
Protein arginine N-methyltransferase 7	PRMT7	16q22.1	Q9NVM4	details
Calmodulin-lysine N-methyltransferase	CAMKMT	2p21	Q7Z624	details
Probable dimethyladenosine transferase	DIMT1	5q12.1	Q9UNQ2	details
HemK methyltransferase family member 1	HEMK1		Q9Y5R4	details
Small RNA 2'-O-methyltransferase	HENMT1	1p13.3	Q5T8I9	details
Methyltransferase-like protein 2B	METTL2B		Q6P1Q9	details
Methyltransferase-like protein 6	METTL6		Q8TCB7	details
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1	FTSJD2	6p21.2	Q8N1G2	details
Ribosomal RNA small subunit methyltransferase NEP1	EMG1	12p13.3	Q92979	details
N-terminal Xaa-Pro-Lys N-methyltransferase 1	NTMT1	9q34.11	Q9BV86	details
Alpha N-terminal protein methyltransferase 1B	METTL11B	1q24.2	Q5VVY1	details
Putative histone-lysine N-methyltransferase PRDM6	PRDM6	5q23.2	Q9NQX0	details
Probable histone-lysine N-methyltransferase PRDM7	PRDM7	16q24.3	Q9NQW5	details
Histone-lysine N-methyltransferase PRDM9	PRDM9	5p14	Q9NQV7	details
Histone-lysine N-methyltransferase setd3	SETD3	14q32.2	Q86TU7	details
N-lysine methyltransferase SMYD2	SMYD2	1q32.3	Q9NRG4	details
Trimethylguanosine synthase	TGS1	8q11	Q96RS0	details
Probable tRNA (uracil-O(2)-)-methyltransferase	TRMT44	4p16.1	Q8IYL2	details
Uncharacterized methyltransferase WBSCR22	WBSCR22		O43709	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Putative adenosylhomocysteinase 2	AHCYL1	1p13.2	O43865	details
Histone-lysine N-methyltransferase MLL	MLL	11q23	Q03164	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Catechol O-methyltransferase	COMT	22q11.21	P21964	details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	NSD1	5q35	Q96L73	details
Histone-lysine N-methyltransferase SETDB1	SETDB1	1q21	Q15047	details
DNA (cytosine-5)-methyltransferase 3A	DNMT3A	2p23	Q9Y6K1	details
Histone-lysine N-methyltransferase EHMT2	EHMT2	6p21.31	Q96KQ7	details
Methionine synthase reductase	MTRR	5p15.31	Q9UBK8	details
Histone-lysine N-methyltransferase SUV39H1	SUV39H1	Xp11.23	O43463	details
Histone-lysine N-methyltransferase SUV39H2	SUV39H2	10p13	Q9H5I1	details
Histone-lysine N-methyltransferase EHMT1	EHMT1	9q34.3	Q9H9B1	details
PR domain zinc finger protein 2	PRDM2	1p36.21	Q13029	details
Histone-lysine N-methyltransferase MLL	MLL	11q23	Q03164	details
DNA (cytosine-5)-methyltransferase 3B	DNMT3B	20q11.2	Q9UBC3	details
Histone-lysine N-methyltransferase MLL3	MLL3	7q36.1	Q8NEZ4	details
DNA (cytosine-5)-methyltransferase 1	DNMT1	19p13.2	P26358	details
Histone-lysine N-methyltransferase SETDB2	SETDB2	13q14	Q96T68	details
Histone-lysine N-methyltransferase ASH1L	ASH1L	1q22	Q9NR48	details
Histone-lysine N-methyltransferase MLL2	MLL2	12q13.12	O14686	details
Histone-lysine N-methyltransferase MLL4	WBP7	19q13.1	Q9UMN6	details
Histone-lysine N-methyltransferase MLL5	MLL5	7q22.1	Q8IZD2	details
Histone-lysine N-methyltransferase NSD2	WHSC1	4p16.3	O96028	details
Histone-lysine N-methyltransferase NSD3	WHSC1L1	8p11.2	Q9BZ95	details
Histone-lysine N-methyltransferase SETD2	SETD2	3p21.31	Q9BYW2	details
Histone-lysine N-methyltransferase SETMAR	SETMAR	3p26.1	Q53H47	details
Histone-lysine N-methyltransferase SMYD3	SMYD3	1q44	Q9H7B4	details
tRNA:m(4)X modification enzyme TRM13 homolog	TRMT13	1p21.2	Q9NUP7	details
tRNA (guanine(26)-N(2))-dimethyltransferase	TRMT1	19p13.2	Q9NXH9	details
DNA (cytosine-5)-methyltransferase 3-like	DNMT3L		Q9UJW3	details
Alkylated DNA repair protein alkB homolog 8	ALKBH8	11q22.3	Q96BT7	details
Small RNA 2'-O-methyltransferase	HENMT1	1p13.3	Q5T8I9	details
Putative histone-lysine N-methyltransferase PRDM6	PRDM6	5q23.2	Q9NQX0	details
Histone-lysine N-methyltransferase PRDM9	PRDM9	5p14	Q9NQV7	details
N-lysine methyltransferase SMYD2	SMYD2	1q32.3	Q9NRG4	details
Probable tRNA (uracil-O(2)-)-methyltransferase	TRMT44	4p16.1	Q8IYL2	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	NSD1	5q35	Q96L73	details
Histone-arginine methyltransferase CARM1	CARM1	19p13.2	Q86X55	details
Histone-lysine N-methyltransferase EZH2	EZH2	7q35-q36	Q15910	details
Histone-lysine N-methyltransferase MLL2	MLL2	12q13.12	O14686	details
Histone-lysine N-methyltransferase MLL5	MLL5	7q22.1	Q8IZD2	details
Transmembrane O-methyltransferase	LRTOMT	11q13.4	Q8WZ04	details
Protein arginine N-methyltransferase 1	PRMT1	19q13.3	Q99873	details
Protein arginine N-methyltransferase 2	PRMT2	21q22.3	P55345	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Histone-lysine N-methyltransferase, H3 lysine-79 specific	DOT1L	19p13.3	Q8TEK3	details
Histone-lysine N-methyltransferase SETD7	SETD7	4q28	Q8WTS6	details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	NSD1	5q35	Q96L73	details
Histone-lysine N-methyltransferase SETDB1	SETDB1	1q21	Q15047	details
DNA (cytosine-5)-methyltransferase 3A	DNMT3A	2p23	Q9Y6K1	details
Histone-lysine N-methyltransferase EHMT2	EHMT2	6p21.31	Q96KQ7	details
Histone-lysine N-methyltransferase SUV39H1	SUV39H1	Xp11.23	O43463	details
Histone-lysine N-methyltransferase SUV39H2	SUV39H2	10p13	Q9H5I1	details
Histone-lysine N-methyltransferase EHMT1	EHMT1	9q34.3	Q9H9B1	details
Protein arginine N-methyltransferase 5	PRMT5	14q11.2	O14744	details
Histone-lysine N-methyltransferase SETD1A	SETD1A	16p11.2	O15047	details
PR domain zinc finger protein 2	PRDM2	1p36.21	Q13029	details
Histone-lysine N-methyltransferase MLL	MLL	11q23	Q03164	details
DNA (cytosine-5)-methyltransferase 3B	DNMT3B	20q11.2	Q9UBC3	details
N-lysine methyltransferase SETD8	SETD8	12q24.31	Q9NQR1	details
Histone-lysine N-methyltransferase MLL3	MLL3	7q36.1	Q8NEZ4	details
DNA (cytosine-5)-methyltransferase 1	DNMT1	19p13.2	P26358	details
Histone-lysine N-methyltransferase SETDB2	SETDB2	13q14	Q96T68	details
Histone-lysine N-methyltransferase ASH1L	ASH1L	1q22	Q9NR48	details
Histone-arginine methyltransferase CARM1	CARM1	19p13.2	Q86X55	details
Histone-lysine N-methyltransferase EZH2	EZH2	7q35-q36	Q15910	details
mRNA cap guanine-N7 methyltransferase	RNMT	18p11.21	O43148	details
Histone-lysine N-methyltransferase MLL2	MLL2	12q13.12	O14686	details
Histone-lysine N-methyltransferase MLL4	WBP7	19q13.1	Q9UMN6	details
Histone-lysine N-methyltransferase MLL5	MLL5	7q22.1	Q8IZD2	details
Histone-lysine N-methyltransferase NSD2	WHSC1	4p16.3	O96028	details
Histone-lysine N-methyltransferase NSD3	WHSC1L1	8p11.2	Q9BZ95	details
Histone-lysine N-methyltransferase SETD1B	SETD1B	12q24.31	Q9UPS6	details
Histone-lysine N-methyltransferase SETD2	SETD2	3p21.31	Q9BYW2	details
Histone-lysine N-methyltransferase SUV420H1	SUV420H1	11q13.2	Q4FZB7	details
Histone-lysine N-methyltransferase SUV420H2	SUV420H2	19q13.42	Q86Y97	details
DNA (cytosine-5)-methyltransferase 3-like	DNMT3L		Q9UJW3	details
Histone-lysine N-methyltransferase EZH1	EZH1	17q21.1-q21.3	Q92800	details
Protein arginine N-methyltransferase 2	PRMT2	21q22.3	P55345	details
Protein arginine N-methyltransferase 6	PRMT6	1p13.3	Q96LA8	details
Protein arginine N-methyltransferase 7	PRMT7	16q22.1	Q9NVM4	details
Putative histone-lysine N-methyltransferase PRDM6	PRDM6	5q23.2	Q9NQX0	details
Probable histone-lysine N-methyltransferase PRDM7	PRDM7	16q24.3	Q9NQW5	details
Histone-lysine N-methyltransferase PRDM9	PRDM9	5p14	Q9NQV7	details
Histone-lysine N-methyltransferase setd3	SETD3	14q32.2	Q86TU7	details
N-lysine methyltransferase SMYD2	SMYD2	1q32.3	Q9NRG4	details
Trimethylguanosine synthase	TGS1	8q11	Q96RS0	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000939

DrugBank ID

DB01752

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

S-Adenosyl-L-homocysteine

METLIN ID

296

PubChem Compound

439155

PDB ID

Not Available

ChEBI ID

16680

References

General References

Not Available

Only showing the first 10 proteins. There are 175 proteins in total.

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Enzymes

Enzyme Details

1. Phosphatidylethanolamine N-methyltransferase

General function:: Involved in N-methyltransferase activity
Specific function:: Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
Gene Name:: PEMT
Uniprot ID:: Q9UBM1
Molecular weight:: 23697.395

Enzyme Details

2. Acetylserotonin O-methyltransferase

General function:: Involved in O-methyltransferase activity
Specific function:: Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.
Gene Name:: ASMT
Uniprot ID:: P46597
Molecular weight:: 41660.34

Enzyme Details

3. Catechol O-methyltransferase

General function:: Involved in magnesium ion binding
Specific function:: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Gene Name:: COMT
Uniprot ID:: P21964
Molecular weight:: 30036.77

Enzyme Details

4. Histone-lysine N-methyltransferase, H3 lysine-79 specific

General function:: Involved in DNA binding
Specific function:: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Gene Name:: DOT1L
Uniprot ID:: Q8TEK3
Molecular weight:: 164854.41

Enzyme Details

5. Glycine N-methyltransferase

General function:: Involved in folic acid binding
Specific function:: Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
Gene Name:: GNMT
Uniprot ID:: Q14749
Molecular weight:: 32742.0

Enzyme Details

6. Histone-lysine N-methyltransferase SETD7

General function:: Involved in histone-lysine N-methyltransferase activity
Specific function:: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Gene Name:: SETD7
Uniprot ID:: Q8WTS6
Molecular weight:: 40720.595

Enzyme Details

7. Phenylethanolamine N-methyltransferase

General function:: Involved in methyltransferase activity
Specific function:: Converts noradrenaline to adrenaline.
Gene Name:: PNMT
Uniprot ID:: P11086
Molecular weight:: 30854.745

Enzyme Details

8. Diphthine synthase

General function:: Involved in methyltransferase activity
Specific function:: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis (By similarity).
Gene Name:: DPH5
Uniprot ID:: Q9H2P9
Molecular weight:: 31651.17

Enzyme Details

9. Arsenite methyltransferase

General function:: Involved in methyltransferase activity
Specific function:: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).
Gene Name:: AS3MT
Uniprot ID:: Q9HBK9
Molecular weight:: 41747.49

Enzyme Details

10. Mitochondrial tRNA-specific 2-thiouridylase 1

General function:: Involved in transferase activity
Specific function:: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2- thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base
Gene Name:: TRMU
Uniprot ID:: O75648
Molecular weight:: 47744.3

Transporters

Enzyme Details

1. Putative adenosylhomocysteinase 2

General function:: Involved in adenosylhomocysteinase activity
Specific function:: Not Available
Gene Name:: AHCYL1
Uniprot ID:: O43865
Molecular weight:: 53753.0

Enzyme Details

2. Histone-lysine N-methyltransferase MLL

General function:: Involved in DNA binding
Specific function:: Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.
Gene Name:: MLL
Uniprot ID:: Q03164
Molecular weight:: 432047.735

Only showing the first 10 proteins. There are 175 proteins in total.

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Showing Compound Card for S-Adenosylhomocysteine (CDB004872)

Structure for CDB004872 (S-Adenosylhomocysteine)

Enzymes

Transporters