Record Information
Version1.0
Created at2020-04-17 18:45:30 UTC
Updated at2020-12-07 19:11:09 UTC
CannabisDB IDCDB004872
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameS-Adenosylhomocysteine
DescriptionS-Adenosylhomocysteine, also known as adenosyl-homo-cys or adohcy, belongs to the class of organic compounds known as gamma butyrolactones. Gamma butyrolactones are compounds containing a gamma butyrolactone moiety, which consists of an aliphatic five-member ring with four carbon atoms, one oxygen atom, and bears a ketone group on the carbon adjacent to the oxygen atom. An organic sulfide that is the S-adenosyl derivative of L-homocysteine. S-Adenosylhomocysteine is a very strong basic compound (based on its pKa). S-Adenosylhomocysteine exists in all living species, ranging from bacteria to humans. Outside of the human body, S-Adenosylhomocysteine has been detected, but not quantified in, several different foods, such as arrowhead, guava, purslanes, kiwis, and gooseberries. This could make S-adenosylhomocysteine a potential biomarker for the consumption of these foods. S-Adenosylhomocysteine is a potentially toxic compound. S-Adenosylhomocysteine is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
(2S)-2-Amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoic acidChEBI
2-S-Adenosyl-L-homocysteineChEBI
Adenosyl-L-homocysteineChEBI
AdenosylhomocysteineChEBI
AdoHcyChEBI
S-(5'-Adenosyl)-L-homocysteineChEBI
S-[1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl]-L-homocysteineChEBI
SAHChEBI
(2S)-2-Amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoateGenerator
(2S)-2-Amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulphanyl)butanoateGenerator
(2S)-2-Amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulphanyl)butanoic acidGenerator
S-[1-(Adenin-9-yl)-1,5-dideoxy-b-D-ribofuranos-5-yl]-L-homocysteineGenerator
S-[1-(Adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl]-L-homocysteineGenerator
(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosineHMDB
5'-Deoxy-S-adenosyl-L-homocysteineHMDB
5'-S-(3-Amino-3-carboxypropyl)-5'-thio-L-adenosineHMDB
Adenosyl-homo-cysHMDB
Adenosylhomo-cysHMDB
FormycinylhomocysteineHMDB
L-5'-S-(3-Amino-3-carboxypropyl)-5'-thior-adenosineHMDB
L-S-Adenosyl-homocysteineHMDB
L-S-AdenosylhomocysteineHMDB
S-(5'-Deoxyadenosin-5'-yl)-L-homocysteineHMDB
S-(5'-Deoxyadenosine-5')-L-homocysteineHMDB
S-Adenosyl-homocysteineHMDB
S-Adenosyl-L-homocysteineHMDB
Adenosylhomocysteine, SHMDB
S AdenosylhomocysteineHMDB
Chemical FormulaC14H20N6O5S
Average Molecular Weight384.41
Monoisotopic Molecular Weight384.1216
IUPAC Name(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acid
Traditional NameS-adenosyl-L-homocysteine
CAS Registry Number979-92-0
SMILES
N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C(O)=O
InChI Identifier
InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChI KeyZJUKTBDSGOFHSH-WFMPWKQPSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as gamma butyrolactones. Gamma butyrolactones are compounds containing a gamma butyrolactone moiety, which consists of an aliphatic five-member ring with four carbon atoms, one oxygen atom, and bears a ketone group on the carbon adjacent to the oxygen atom.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassLactones
Sub ClassGamma butyrolactones
Direct ParentGamma butyrolactones
Alternative Parents
Substituents
  • Gamma butyrolactone
  • Tetrahydrofuran
  • Secondary alcohol
  • Carboxylic acid ester
  • 1,2-diol
  • Oxacycle
  • Monocarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Indirect biological role:

Industrial application:

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point209 - 211 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-2.4ALOGPS
logP-4ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)1.81ChemAxon
pKa (Strongest Basic)9.5ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area182.63 ŲChemAxon
Rotatable Bond Count7ChemAxon
Refractivity92.72 m³·mol⁻¹ChemAxon
Polarizability38.41 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSS-Adenosylhomocysteine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0a6u-9853000000-441f171739659ea2b5f6Spectrum
Predicted GC-MSS-Adenosylhomocysteine, 3 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-004r-7096060000-d32383fe3b85ef1b9032Spectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0006-0943000000-80fa5c7d919e1085bc5dSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-00di-0900000000-3f143852503952daa0a8Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-03di-0900000000-23694a4b657a3478ad91Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0udr-0980000000-a8f61dcdc8693e2725f5Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-00kf-0974000000-b3f3632635b2847bf4d2Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-00di-0900000000-188a77c79aaefae8a184Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000i-0900000000-b848c20d743785117445Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0udr-0980000000-64b7b303fc07300e0782Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-001i-0319020200-859d659a39a790a582f1Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0a4i-0900000000-53acf4e10681047da062Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-001i-0910000000-5896502e31d66786e12aSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-001i-0009000000-01ea51599f8d30dec7feSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-001i-0409000100-2de58945ab0dfa81f099Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0a4i-1900000000-a640f1a0bafd33afdd2dSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-001i-0910000000-5f685035af9b243ccff2Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-001i-0009000000-8d01fd0969e47d3bcc5cSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-000i-2901000000-6c40a4a43a8c3e142eceSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-001i-0902000000-c6c0d5529cf011d89f7bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT , negativesplash10-0a4i-0900000000-53acf4e10681047da062Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-1905000000-71a19cb77ac6797e6d81Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-1900000000-11e0ecd68eec9b6ef4f5Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000i-5900000000-c10849015d4b1c3ef749Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-001i-0925000000-384762ca7868d8aa06ddSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-001i-1900000000-2fb047bdcd6fb31842eaSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-053r-2900000000-a6bc4489e6fe48ead399Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
2D NMR[1H,1H] 2D NMR SpectrumSpectrum
2D NMR[1H,13C] 2D NMR SpectrumSpectrum
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Phosphatidylethanolamine N-methyltransferasePEMT17p11.2Q9UBM1 details
Acetylserotonin O-methyltransferaseASMTXp22.3 or Yp11.3P46597 details
Catechol O-methyltransferaseCOMT22q11.21P21964 details
Histone-lysine N-methyltransferase, H3 lysine-79 specificDOT1L19p13.3Q8TEK3 details
Glycine N-methyltransferaseGNMT6p12Q14749 details
Histone-lysine N-methyltransferase SETD7SETD74q28Q8WTS6 details
Phenylethanolamine N-methyltransferasePNMT17qP11086 details
Diphthine synthaseDPH51p21.2Q9H2P9 details
Arsenite methyltransferaseAS3MT10q24.32Q9HBK9 details
Mitochondrial tRNA-specific 2-thiouridylase 1TRMU22q13O75648 details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificNSD15q35Q96L73 details
Histone-lysine N-methyltransferase SETDB1SETDB11q21Q15047 details
Protein-L-isoaspartate(D-aspartate) O-methyltransferasePCMT16q24-q25P22061 details
Protein-S-isoprenylcysteine O-methyltransferaseICMT1p36.21O60725 details
Indolethylamine N-methyltransferaseINMT7p14.3O95050 details
DNA (cytosine-5)-methyltransferase 3ADNMT3A2p23Q9Y6K1 details
Hexaprenyldihydroxybenzoate methyltransferase, mitochondrialCOQ36q16.2Q9NZJ6 details
Histone-lysine N-methyltransferase EHMT2EHMT26p21.31Q96KQ7 details
Methionine synthase reductaseMTRR5p15.31Q9UBK8 details
Histone-lysine N-methyltransferase SUV39H1SUV39H1Xp11.23O43463 details
Nicotinamide N-methyltransferaseNNMT11q23.1P40261 details
Histone-lysine N-methyltransferase SUV39H2SUV39H210p13Q9H5I1 details
Histone-lysine N-methyltransferase EHMT1EHMT19q34.3Q9H9B1 details
Guanidinoacetate N-methyltransferaseGAMT19p13.3Q14353 details
Histamine N-methyltransferaseHNMT2q22.1P50135 details
Thiopurine S-methyltransferaseTPMT6p22.3P51580 details
N6-adenosine-methyltransferase 70 kDa subunitMETTL314q11.1Q86U44 details
Putative adenosylhomocysteinase 3AHCYL27q32.1Q96HN2 details
AdenosylhomocysteinaseAHCY20q11.22P23526 details
Putative adenosylhomocysteinase 2AHCYL11p13.2O43865 details
Protein arginine N-methyltransferase 5PRMT514q11.2O14744 details
Histone-lysine N-methyltransferase SETD1ASETD1A16p11.2O15047 details
Histone-lysine N-methyltransferase MLLMLL11q23Q03164 details
DNA (cytosine-5)-methyltransferase 3BDNMT3B20q11.2Q9UBC3 details
tRNA (cytosine(38)-C(5))-methyltransferaseTRDMT110p15.1O14717 details
N-lysine methyltransferase SETD8SETD812q24.31Q9NQR1 details
Histone-lysine N-methyltransferase MLL3MLL37q36.1Q8NEZ4 details
DNA (cytosine-5)-methyltransferase 1DNMT119p13.2P26358 details
Histone-lysine N-methyltransferase SETDB2SETDB213q14Q96T68 details
tRNA (cytosine(34)-C(5))-methyltransferaseNSUN25p15.31Q08J23 details
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialCOQ512q24.31Q5HYK3 details
Histone-lysine N-methyltransferase ASH1LASH1L1q22Q9NR48 details
Histone-arginine methyltransferase CARM1CARM119p13.2Q86X55 details
Histone-lysine N-methyltransferase EZH2EZH27q35-q36Q15910 details
mRNA cap guanine-N7 methyltransferaseRNMT18p11.21O43148 details
Histone-lysine N-methyltransferase MLL2MLL212q13.12O14686 details
Histone-lysine N-methyltransferase MLL4WBP719q13.1Q9UMN6 details
Histone-lysine N-methyltransferase MLL5MLL57q22.1Q8IZD2 details
Histone-lysine N-methyltransferase NSD2WHSC14p16.3O96028 details
Histone-lysine N-methyltransferase NSD3WHSC1L18p11.2Q9BZ95 details
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferaseFTSJ1Xp11.23Q9UET6 details
Putative ribosomal RNA methyltransferase 2FTSJ27p22Q9UI43 details
Histone-lysine N-methyltransferase SETD1BSETD1B12q24.31Q9UPS6 details
Histone-lysine N-methyltransferase SETD2SETD23p21.31Q9BYW2 details
Histone-lysine N-methyltransferase SETMARSETMAR3p26.1Q53H47 details
Histone-lysine N-methyltransferase SMYD3SMYD31q44Q9H7B4 details
Histone-lysine N-methyltransferase SUV420H1SUV420H111q13.2Q4FZB7 details
Histone-lysine N-methyltransferase SUV420H2SUV420H219q13.42Q86Y97 details
tRNA (guanine(26)-N(2))-dimethyltransferaseTRMT119p13.2Q9NXH9 details
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61ATRMT61A14q32Q96FX7 details
tRNA (guanine-N(7)-)-methyltransferaseMETTL112q13Q9UBP6 details
tRNA (adenine(58)-N(1))-methyltransferase, mitochondrialTRMT61B2p23.2Q9BVS5 details
tRNA (guanine(37)-N1)-methyltransferaseTRMT514q23.1Q32P41 details
Transmembrane O-methyltransferaseLRTOMT11q13.4Q8WZ04 details
DNA (cytosine-5)-methyltransferase 3-likeDNMT3LQ9UJW3 details
Histone-lysine N-methyltransferase EZH1EZH117q21.1-q21.3Q92800 details
Leucine carboxyl methyltransferase 1LCMT116p12.1Q9UIC8 details
tRNA (uracil(54)-C(5))-methyltransferase homologTRMT2BXq22.1Q96GJ1 details
Protein arginine N-methyltransferase 1PRMT119q13.3Q99873 details
Protein arginine N-methyltransferase 2PRMT221q22.3P55345 details
Protein arginine N-methyltransferase 6PRMT61p13.3Q96LA8 details
Protein arginine N-methyltransferase 7PRMT716q22.1Q9NVM4 details
Calmodulin-lysine N-methyltransferaseCAMKMT2p21Q7Z624 details
Probable dimethyladenosine transferaseDIMT15q12.1Q9UNQ2 details
HemK methyltransferase family member 1HEMK1Q9Y5R4 details
Small RNA 2'-O-methyltransferaseHENMT11p13.3Q5T8I9 details
Methyltransferase-like protein 2BMETTL2BQ6P1Q9 details
Methyltransferase-like protein 6METTL6Q8TCB7 details
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1FTSJD26p21.2Q8N1G2 details
Ribosomal RNA small subunit methyltransferase NEP1EMG112p13.3Q92979 details
N-terminal Xaa-Pro-Lys N-methyltransferase 1NTMT19q34.11Q9BV86 details
Alpha N-terminal protein methyltransferase 1BMETTL11B1q24.2Q5VVY1 details
Putative histone-lysine N-methyltransferase PRDM6PRDM65q23.2Q9NQX0 details
Probable histone-lysine N-methyltransferase PRDM7PRDM716q24.3Q9NQW5 details
Histone-lysine N-methyltransferase PRDM9PRDM95p14Q9NQV7 details
Histone-lysine N-methyltransferase setd3SETD314q32.2Q86TU7 details
N-lysine methyltransferase SMYD2SMYD21q32.3Q9NRG4 details
Trimethylguanosine synthaseTGS18q11Q96RS0 details
Probable tRNA (uracil-O(2)-)-methyltransferaseTRMT444p16.1Q8IYL2 details
Uncharacterized methyltransferase WBSCR22WBSCR22O43709 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Putative adenosylhomocysteinase 2AHCYL11p13.2O43865 details
Histone-lysine N-methyltransferase MLLMLL11q23Q03164 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Catechol O-methyltransferaseCOMT22q11.21P21964 details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificNSD15q35Q96L73 details
Histone-lysine N-methyltransferase SETDB1SETDB11q21Q15047 details
DNA (cytosine-5)-methyltransferase 3ADNMT3A2p23Q9Y6K1 details
Histone-lysine N-methyltransferase EHMT2EHMT26p21.31Q96KQ7 details
Methionine synthase reductaseMTRR5p15.31Q9UBK8 details
Histone-lysine N-methyltransferase SUV39H1SUV39H1Xp11.23O43463 details
Histone-lysine N-methyltransferase SUV39H2SUV39H210p13Q9H5I1 details
Histone-lysine N-methyltransferase EHMT1EHMT19q34.3Q9H9B1 details
PR domain zinc finger protein 2PRDM21p36.21Q13029 details
Histone-lysine N-methyltransferase MLLMLL11q23Q03164 details
DNA (cytosine-5)-methyltransferase 3BDNMT3B20q11.2Q9UBC3 details
Histone-lysine N-methyltransferase MLL3MLL37q36.1Q8NEZ4 details
DNA (cytosine-5)-methyltransferase 1DNMT119p13.2P26358 details
Histone-lysine N-methyltransferase SETDB2SETDB213q14Q96T68 details
Histone-lysine N-methyltransferase ASH1LASH1L1q22Q9NR48 details
Histone-lysine N-methyltransferase MLL2MLL212q13.12O14686 details
Histone-lysine N-methyltransferase MLL4WBP719q13.1Q9UMN6 details
Histone-lysine N-methyltransferase MLL5MLL57q22.1Q8IZD2 details
Histone-lysine N-methyltransferase NSD2WHSC14p16.3O96028 details
Histone-lysine N-methyltransferase NSD3WHSC1L18p11.2Q9BZ95 details
Histone-lysine N-methyltransferase SETD2SETD23p21.31Q9BYW2 details
Histone-lysine N-methyltransferase SETMARSETMAR3p26.1Q53H47 details
Histone-lysine N-methyltransferase SMYD3SMYD31q44Q9H7B4 details
tRNA:m(4)X modification enzyme TRM13 homologTRMT131p21.2Q9NUP7 details
tRNA (guanine(26)-N(2))-dimethyltransferaseTRMT119p13.2Q9NXH9 details
DNA (cytosine-5)-methyltransferase 3-likeDNMT3LQ9UJW3 details
Alkylated DNA repair protein alkB homolog 8ALKBH811q22.3Q96BT7 details
Small RNA 2'-O-methyltransferaseHENMT11p13.3Q5T8I9 details
Putative histone-lysine N-methyltransferase PRDM6PRDM65q23.2Q9NQX0 details
Histone-lysine N-methyltransferase PRDM9PRDM95p14Q9NQV7 details
N-lysine methyltransferase SMYD2SMYD21q32.3Q9NRG4 details
Probable tRNA (uracil-O(2)-)-methyltransferaseTRMT444p16.1Q8IYL2 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificNSD15q35Q96L73 details
Histone-arginine methyltransferase CARM1CARM119p13.2Q86X55 details
Histone-lysine N-methyltransferase EZH2EZH27q35-q36Q15910 details
Histone-lysine N-methyltransferase MLL2MLL212q13.12O14686 details
Histone-lysine N-methyltransferase MLL5MLL57q22.1Q8IZD2 details
Transmembrane O-methyltransferaseLRTOMT11q13.4Q8WZ04 details
Protein arginine N-methyltransferase 1PRMT119q13.3Q99873 details
Protein arginine N-methyltransferase 2PRMT221q22.3P55345 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Histone-lysine N-methyltransferase, H3 lysine-79 specificDOT1L19p13.3Q8TEK3 details
Histone-lysine N-methyltransferase SETD7SETD74q28Q8WTS6 details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificNSD15q35Q96L73 details
Histone-lysine N-methyltransferase SETDB1SETDB11q21Q15047 details
DNA (cytosine-5)-methyltransferase 3ADNMT3A2p23Q9Y6K1 details
Histone-lysine N-methyltransferase EHMT2EHMT26p21.31Q96KQ7 details
Histone-lysine N-methyltransferase SUV39H1SUV39H1Xp11.23O43463 details
Histone-lysine N-methyltransferase SUV39H2SUV39H210p13Q9H5I1 details
Histone-lysine N-methyltransferase EHMT1EHMT19q34.3Q9H9B1 details
Protein arginine N-methyltransferase 5PRMT514q11.2O14744 details
Histone-lysine N-methyltransferase SETD1ASETD1A16p11.2O15047 details
PR domain zinc finger protein 2PRDM21p36.21Q13029 details
Histone-lysine N-methyltransferase MLLMLL11q23Q03164 details
DNA (cytosine-5)-methyltransferase 3BDNMT3B20q11.2Q9UBC3 details
N-lysine methyltransferase SETD8SETD812q24.31Q9NQR1 details
Histone-lysine N-methyltransferase MLL3MLL37q36.1Q8NEZ4 details
DNA (cytosine-5)-methyltransferase 1DNMT119p13.2P26358 details
Histone-lysine N-methyltransferase SETDB2SETDB213q14Q96T68 details
Histone-lysine N-methyltransferase ASH1LASH1L1q22Q9NR48 details
Histone-arginine methyltransferase CARM1CARM119p13.2Q86X55 details
Histone-lysine N-methyltransferase EZH2EZH27q35-q36Q15910 details
mRNA cap guanine-N7 methyltransferaseRNMT18p11.21O43148 details
Histone-lysine N-methyltransferase MLL2MLL212q13.12O14686 details
Histone-lysine N-methyltransferase MLL4WBP719q13.1Q9UMN6 details
Histone-lysine N-methyltransferase MLL5MLL57q22.1Q8IZD2 details
Histone-lysine N-methyltransferase NSD2WHSC14p16.3O96028 details
Histone-lysine N-methyltransferase NSD3WHSC1L18p11.2Q9BZ95 details
Histone-lysine N-methyltransferase SETD1BSETD1B12q24.31Q9UPS6 details
Histone-lysine N-methyltransferase SETD2SETD23p21.31Q9BYW2 details
Histone-lysine N-methyltransferase SUV420H1SUV420H111q13.2Q4FZB7 details
Histone-lysine N-methyltransferase SUV420H2SUV420H219q13.42Q86Y97 details
DNA (cytosine-5)-methyltransferase 3-likeDNMT3LQ9UJW3 details
Histone-lysine N-methyltransferase EZH1EZH117q21.1-q21.3Q92800 details
Protein arginine N-methyltransferase 2PRMT221q22.3P55345 details
Protein arginine N-methyltransferase 6PRMT61p13.3Q96LA8 details
Protein arginine N-methyltransferase 7PRMT716q22.1Q9NVM4 details
Putative histone-lysine N-methyltransferase PRDM6PRDM65q23.2Q9NQX0 details
Probable histone-lysine N-methyltransferase PRDM7PRDM716q24.3Q9NQW5 details
Histone-lysine N-methyltransferase PRDM9PRDM95p14Q9NQV7 details
Histone-lysine N-methyltransferase setd3SETD314q32.2Q86TU7 details
N-lysine methyltransferase SMYD2SMYD21q32.3Q9NRG4 details
Trimethylguanosine synthaseTGS18q11Q96RS0 details
Concentrations Data
Not Available
HMDB IDHMDB0000939
DrugBank IDDB01752
Phenol Explorer Compound IDNot Available
FoodDB IDFDB031150
KNApSAcK IDC00007230
Chemspider ID388301
KEGG Compound IDC00021
BioCyc IDADENOSYL-HOMO-CYS
BiGG ID33543
Wikipedia LinkS-Adenosyl-L-homocysteine
METLIN ID296
PubChem Compound439155
PDB IDNot Available
ChEBI ID16680
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 175 proteins in total.

Enzymes

General function:
Involved in N-methyltransferase activity
Specific function:
Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC).
Gene Name:
PEMT
Uniprot ID:
Q9UBM1
Molecular weight:
23697.395
General function:
Involved in O-methyltransferase activity
Specific function:
Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.
Gene Name:
ASMT
Uniprot ID:
P46597
Molecular weight:
41660.34
General function:
Involved in magnesium ion binding
Specific function:
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Gene Name:
COMT
Uniprot ID:
P21964
Molecular weight:
30036.77
General function:
Involved in DNA binding
Specific function:
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Gene Name:
DOT1L
Uniprot ID:
Q8TEK3
Molecular weight:
164854.41
General function:
Involved in folic acid binding
Specific function:
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
Gene Name:
GNMT
Uniprot ID:
Q14749
Molecular weight:
32742.0
General function:
Involved in histone-lysine N-methyltransferase activity
Specific function:
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Gene Name:
SETD7
Uniprot ID:
Q8WTS6
Molecular weight:
40720.595
General function:
Involved in methyltransferase activity
Specific function:
Converts noradrenaline to adrenaline.
Gene Name:
PNMT
Uniprot ID:
P11086
Molecular weight:
30854.745
General function:
Involved in methyltransferase activity
Specific function:
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis (By similarity).
Gene Name:
DPH5
Uniprot ID:
Q9H2P9
Molecular weight:
31651.17
General function:
Involved in methyltransferase activity
Specific function:
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).
Gene Name:
AS3MT
Uniprot ID:
Q9HBK9
Molecular weight:
41747.49
General function:
Involved in transferase activity
Specific function:
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2- thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base
Gene Name:
TRMU
Uniprot ID:
O75648
Molecular weight:
47744.3

Transporters

General function:
Involved in adenosylhomocysteinase activity
Specific function:
Not Available
Gene Name:
AHCYL1
Uniprot ID:
O43865
Molecular weight:
53753.0
General function:
Involved in DNA binding
Specific function:
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.
Gene Name:
MLL
Uniprot ID:
Q03164
Molecular weight:
432047.735

Only showing the first 10 proteins. There are 175 proteins in total.