Record Information
Version1.0
Created at2020-04-17 19:08:49 UTC
Updated at2020-12-07 19:11:34 UTC
CannabisDB IDCDB005095
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameGuanosine diphosphate
DescriptionGuanosine diphosphate, also known as 5'-GDP or 5'-diphosphate, guanosine, belongs to the class of organic compounds known as purine ribonucleoside diphosphates. These are purine ribobucleotides with diphosphate group linked to the ribose moiety. Guanosine diphosphate is a moderately basic compound (based on its pKa). Guanosine diphosphate exists in all living species, ranging from bacteria to humans. In humans, guanosine diphosphate is involved in intracellular signalling through adenosine receptor A2B and adenosine. Outside of the human body, Guanosine diphosphate has been detected, but not quantified in, several different foods, such as devilfish, java plums, green beans, almonds, and orange mints. This could make guanosine diphosphate a potential biomarker for the consumption of these foods. A purine ribonucleoside 5'-diphosphate resulting from the formal condensation of the hydroxy group at the 5' position of guanosine with pyrophosphoric acid. Guanosine diphosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
Guanosine 5'-diphosphateChEBI
Guanosine 5'-diphosphoric acidGenerator
Guanosine diphosphoric acidGenerator
5'-GDPHMDB
GDPHMDB
Guanosine 5'-(trihydrogen pyrophosphate)HMDB
Guanosine 5'-pyrophosphateHMDB
Guanosine mono(trihydrogen diphosphate)HMDB
Guanosine pyrophosphateHMDB
Guanosine-5'-diphosphateHMDB
Guanosine-diphosphateHMDB
PpGHMDB
5'-Diphosphate, guanosineHMDB
Diphosphate, guanosine 5'-trihydrogenHMDB
Guanosine 5' diphosphateHMDB
Guanosine 5' trihydrogen diphosphateHMDB
5'-Trihydrogen diphosphate, guanosineHMDB
Diphosphate, guanosineHMDB
Guanosine 5'-trihydrogen diphosphateHMDB
Chemical FormulaC10H15N5O11P2
Average Molecular Weight443.2
Monoisotopic Molecular Weight443.0243
IUPAC Name[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid
Traditional Name{[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxyphosphonic acid
CAS Registry Number146-91-8
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
InChI Identifier
InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChI KeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as purine ribonucleoside diphosphates. These are purine ribobucleotides with diphosphate group linked to the ribose moiety.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
ClassPurine nucleotides
Sub ClassPurine ribonucleotides
Direct ParentPurine ribonucleoside diphosphates
Alternative Parents
Substituents
  • Purine ribonucleoside diphosphate
  • Purine ribonucleoside monophosphate
  • Pentose phosphate
  • Pentose-5-phosphate
  • Glycosyl compound
  • N-glycosyl compound
  • 6-oxopurine
  • Hypoxanthine
  • Monosaccharide phosphate
  • Organic pyrophosphate
  • Pentose monosaccharide
  • Imidazopyrimidine
  • Purine
  • Aminopyrimidine
  • Monoalkyl phosphate
  • Pyrimidone
  • Monosaccharide
  • N-substituted imidazole
  • Organic phosphoric acid derivative
  • Alkyl phosphate
  • Phosphoric acid ester
  • Pyrimidine
  • Vinylogous amide
  • Tetrahydrofuran
  • Azole
  • Imidazole
  • Heteroaromatic compound
  • Secondary alcohol
  • 1,2-diol
  • Organoheterocyclic compound
  • Azacycle
  • Oxacycle
  • Organooxygen compound
  • Organic nitrogen compound
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Alcohol
  • Amine
  • Organic oxygen compound
  • Primary amine
  • Organonitrogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-1.5ALOGPS
logP-3.7ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)1.71ChemAxon
pKa (Strongest Basic)2.55ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count13ChemAxon
Hydrogen Donor Count7ChemAxon
Polar Surface Area248.28 ŲChemAxon
Rotatable Bond Count6ChemAxon
Refractivity85.93 m³·mol⁻¹ChemAxon
Polarizability34.74 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSGuanosine diphosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-004i-5930200000-bdc0893316c12636a495Spectrum
Predicted GC-MSGuanosine diphosphate, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0229-6393250000-a57b7f18975223fa888cSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0udl-0900600000-5c7173a5771dfefadc5eSpectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0udi-0900000000-d38af29994fa5108c331Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0udi-0900000000-3072d857dcc8a1b2cbaaSpectrum
MS/MSLC-MS/MS Spectrum - , negativesplash10-0kdi-5901100000-24a5c807e53370f01d0cSpectrum
MS/MSLC-MS/MS Spectrum - , positivesplash10-0udi-0900000000-6399eaf97235815c4cb7Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0udi-0911300000-fcd49d8a5e9d3dc3f933Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0udi-0900000000-ded96f0f499982ac1ab0Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0udi-0900000000-ac93e95f54842f42e273Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0f6x-0900800000-1ed1199fdace4d1b4d80Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0zir-3900000000-b9aeef613c34fe99a48cSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9200000000-f630c9237e72a76d3d63Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
2D NMR[1H,1H] 2D NMR SpectrumSpectrum
2D NMR[1H,13C] 2D NMR SpectrumSpectrum
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Ectonucleoside triphosphate diphosphohydrolase 1ENTPD110q24P49961 details
Soluble calcium-activated nucleotidase 1CANT117q25.3Q8WVQ1 details
Ectonucleoside triphosphate diphosphohydrolase 3ENTPD33p21.3O75355 details
Uridine-cytidine kinase 1UCK19q34.13Q9HA47 details
Nucleoside diphosphate kinase, mitochondrialNME416p13.3O00746 details
Ribonucleoside-diphosphate reductase large subunitRRM111p15.5P23921 details
Nucleoside diphosphate kinase ANME117q21.3P15531 details
Nucleoside diphosphate kinase 7NME71q24Q9Y5B8 details
Ribonucleoside-diphosphate reductase subunit M2RRM22p25-p24P31350 details
Nucleoside diphosphate kinase BNME217q21.3P22392 details
Nucleoside diphosphate kinase 3NME316q13.3Q13232 details
Nucleoside diphosphate kinase 6NME63p21O75414 details
Fucose-1-phosphate guanylyltransferaseFPGT1p31.1O14772 details
Alpha-1,3/1,6-mannosyltransferase ALG2ALG29q22.33Q9H553 details
Dolichol-phosphate mannosyltransferaseDPM120q13.13O60762 details
GDP-mannose 4,6 dehydrataseGMDS6p25O60547 details
Galactoside 2-alpha-L-fucosyltransferase 2FUT219q13.3Q10981 details
Galactoside 2-alpha-L-fucosyltransferase 1FUT119q13.3P19526 details
6-phosphofructokinase type CPFKP10p15.3-p15.2Q01813 details
6-phosphofructokinase, liver typePFKL21q22.3P17858 details
6-phosphofructokinase, muscle typePFKM12q13.3P08237 details
Pyruvate kinase isozymes M1/M2PKM15q22P14618 details
Pyruvate kinase isozymes R/LPKLR1q21P30613 details
Ectonucleoside triphosphate diphosphohydrolase 4ENTPD48p21.3Q9Y227 details
Ectonucleoside triphosphate diphosphohydrolase 6ENTPD620p11.21O75354 details
Ectonucleoside triphosphate diphosphohydrolase 5ENTPD514q24O75356 details
Adenylosuccinate synthetase isozyme 2ADSS1q44P30520 details
Adenylosuccinate synthetase isozyme 1ADSSL114q32.33Q8N142 details
Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialSUCLG12p11.2P53597 details
Phosphoenolpyruvate carboxykinase [GTP], mitochondrialPCK214q11.2Q16822 details
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrialSUCLG23p14.1Q96I99 details
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]PCK120q13.31P35558 details
GDP-L-fucose synthaseTSTA38q24.3Q13630 details
Guanylate kinaseGUK11q32-q41Q16774 details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrialSUCLA213q12.2-q13.3Q9P2R7 details
Alpha-(1,3)-fucosyltransferaseFUT519p13.3Q11128 details
Polyribonucleotide nucleotidyltransferase 1, mitochondrialPNPT12p15Q8TCS8 details
Rho guanine nucleotide exchange factor 1ARHGEF119q13.13Q92888 details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortGNAS20q13.3P63092 details
VinexinSORBS38p21.3O60504 details
GTPase HRasHRAS11p15.5P01112 details
Guanine nucleotide-binding protein G(q) subunit alphaGNAQ9q21P50148 details
Guanine nucleotide-binding protein subunit alpha-11GNA1119p13.3P29992 details
Chitobiosyldiphosphodolichol beta-mannosyltransferaseALG116p13.3Q9BT22 details
Guanine nucleotide-binding protein G(t) subunit alpha-1GNAT13p21P11488 details
Uridine-cytidine kinase 2UCK21q23Q9BZX2 details
Protein ALEXGNAS20q13.3P84996 details
Lysophosphatidic acid receptor 2LPAR219p12Q9HBW0 details
ENTPD4 proteinENTPD48p21.3Q8NE73 details
Mannose-1-phosphate guanyltransferase betaGMPPB3p21.31Q9Y5P6 details
Mannose-1-phosphate guanyltransferase alphaGMPPA2q35Q96IJ6 details
Alpha-(1,6)-fucosyltransferaseFUT814q24.3Q9BYC5 details
Ribonucleoside-diphosphate reductase subunit M2 BRRM2B8q23.1Q7LG56 details
Uridine-cytidine kinase-like 1UCKL120q13.33Q9NWZ5 details
Ectonucleoside triphosphate diphosphohydrolase 8ENTPD89q34.3Q5MY95 details
GTPase-activating protein and VPS9 domain-containing protein 1GAPVD19q33.3Q14C86 details
Probable E3 ubiquitin-protein ligase HERC1HERC115q22Q15751 details
Interferon-inducible GTPase 5IRGC19q13.31Q6NXR0 details
MAP kinase-activating death domain proteinMADD11p11.2Q8WXG6 details
Putative nucleoside diphosphate kinaseNME2P112q24.31O60361 details
Probable 8-oxo-dGTP diphosphatase NUDT15NUDT1513q14.2Q9NV35 details
8-oxo-dGDP phosphatase NUDT18NUDT188p21.3Q6ZVK8 details
GDP-fucose protein O-fucosyltransferase 1POFUT120q11Q9H488 details
Rho-related GTP-binding protein RhoURHOU1q42.11-q42.3Q7L0Q8 details
GDP-fucose protein O-fucosyltransferase 2POFUT221q22.3Q9Y2G5 details
Protein RCC2RCC21p36.13Q9P258 details
Protein very KINDKNDC110q26.3Q76NI1 details
Nucleoside diphosphate kinaseNME416p13.3A2IDD0 details
Hydroxylysine kinaseAGPHD115q25.1A2RU49 details
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferaseALG1113q14.2Q2TAA5 details
Dolichol-phosphate mannosyltransferase subunit 3DPM3Q9P2X0 details
Galactoside 3(4)-L-fucosyltransferaseFUT319p13.3P21217 details
GDP-D-glucose phosphorylase 1GDPGP115q26.1Q6ZNW5 details
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1HDDC315q26.1Q8N4P3 details
Nucleoside diphosphate kinase homolog 5NME5P56597 details
TransportersNot Available
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Soluble calcium-activated nucleotidase 1CANT117q25.3Q8WVQ1 details
Nucleoside diphosphate kinase, mitochondrialNME416p13.3O00746 details
Nucleoside diphosphate kinase 7NME71q24Q9Y5B8 details
Ribonucleoside-diphosphate reductase subunit M2RRM22p25-p24P31350 details
Nucleoside diphosphate kinase BNME217q21.3P22392 details
Nucleoside diphosphate kinase 3NME316q13.3Q13232 details
Nucleoside diphosphate kinase 6NME63p21O75414 details
6-phosphofructokinase type CPFKP10p15.3-p15.2Q01813 details
6-phosphofructokinase, liver typePFKL21q22.3P17858 details
6-phosphofructokinase, muscle typePFKM12q13.3P08237 details
Pyruvate kinase isozymes M1/M2PKM15q22P14618 details
Pyruvate kinase isozymes R/LPKLR1q21P30613 details
Adenylosuccinate synthetase isozyme 2ADSS1q44P30520 details
Adenylosuccinate synthetase isozyme 1ADSSL114q32.33Q8N142 details
Phosphoenolpyruvate carboxykinase [GTP], mitochondrialPCK214q11.2Q16822 details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrialSUCLA213q12.2-q13.3Q9P2R7 details
Ribonucleoside-diphosphate reductase subunit M2 BRRM2B8q23.1Q7LG56 details
Dedicator of cytokinesis protein 2DOCK25q35.1Q92608 details
Probable 8-oxo-dGTP diphosphatase NUDT15NUDT1513q14.2Q9NV35 details
Ras guanyl-releasing protein 3RASGRP32p25.1-p24.1Q8IV61 details
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1HDDC315q26.1Q8N4P3 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2GNG214q21P59768 details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortGNAS20q13.3P63092 details
Guanine nucleotide-binding protein G(q) subunit alphaGNAQ9q21P50148 details
Guanine nucleotide-binding protein subunit alpha-11GNA1119p13.3P29992 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11GNG117q21P61952 details
Guanine nucleotide-binding protein G(t) subunit alpha-1GNAT13p21P11488 details
Lysophosphatidic acid receptor 2LPAR219p12Q9HBW0 details
Alpha-(1,6)-fucosyltransferaseFUT814q24.3Q9BYC5 details
Dynamin-1DNM19q34Q05193 details
Dynamin-2DNM219p13.2P50570 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10GNG109q31.3P50151 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12GNG121p31.3Q9UBI6 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13GNG1316p13.3Q9P2W3 details
Guanine nucleotide-binding protein G(T) subunit gamma-T1GNGT17q21.3P63211 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3GNG311p11P63215 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4GNG41q42.3P50150 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5GNG51p22P63218 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7GNG719p13.3O60262 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8GNG819q13.32Q9UK08 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2GNGT217q21O14610 details
T-lymphoma invasion and metastasis-inducing protein 2TIAM26q25.2Q8IVF5 details
Guanine nucleotide-binding protein G(i) subunit alpha-1GNAI17q21P63096 details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLasGNAS20q13.3Q5JWF2 details
Guanine nucleotide-binding protein subunit alpha-14GNA149q21O95837 details
Guanine nucleotide-binding protein G(k) subunit alphaGNAI31p13P08754 details
Guanine nucleotide-binding protein G(i) subunit alpha-2GNAI23p21P04899 details
Guanine nucleotide-binding protein G(t) subunit alpha-2GNAT21p13.1P19087 details
Guanine nucleotide-binding protein G(o) subunit alphaGNAO116q13P09471 details
Guanine nucleotide-binding protein subunit alpha-13GNA1317q24.3Q14344 details
Guanine nucleotide binding protein (G protein), alpha 14GNA149q21B1ALW3 details
Guanine nucleotide-binding protein subunit alpha-12GNA127p22.2Q03113 details
Growth factor receptor-bound protein 2GRB217q24-q25P62993 details
Guanine nucleotide binding protein (G protein), q polypeptideGNAQ9q21B1AM21 details
Guanine nucleotide-binding protein G(z) subunit alphaGNAZ22q11.22P19086 details
Guanine nucleotide-binding protein G(olf) subunit alphaGNAL18p11.22-p11.21P38405 details
Guanine nucleotide-binding protein subunit alpha-15GNA1519p13.3P30679 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Ribonucleoside-diphosphate reductase subunit M2RRM22p25-p24P31350 details
Nucleoside diphosphate kinase BNME217q21.3P22392 details
Dynamin-2DNM219p13.2P50570 details
Concentrations Data
Not Available
HMDB IDHMDB0001201
DrugBank IDDB04315
Phenol Explorer Compound IDNot Available
FoodDB IDFDB030875
KNApSAcK IDNot Available
Chemspider ID8630
KEGG Compound IDC00035
BioCyc IDGDP
BiGG ID33599
Wikipedia LinkGuanosine diphosphate
METLIN ID6077
PubChem Compound8977
PDB IDNot Available
ChEBI ID17552
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 135 proteins in total.

Enzymes

General function:
Involved in hydrolase activity
Specific function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:
ENTPD1
Uniprot ID:
P49961
Molecular weight:
58706.0
General function:
Involved in calcium ion binding
Specific function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:
CANT1
Uniprot ID:
Q8WVQ1
Molecular weight:
44839.24
General function:
Involved in hydrolase activity
Specific function:
Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:
ENTPD3
Uniprot ID:
O75355
Molecular weight:
59104.76
General function:
Involved in ATP binding
Specific function:
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Gene Name:
UCK1
Uniprot ID:
Q9HA47
Molecular weight:
22760.43
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).
Gene Name:
NME4
Uniprot ID:
O00746
Molecular weight:
20658.45
General function:
Involved in oxidation reduction
Specific function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Gene Name:
RRM1
Uniprot ID:
P23921
Molecular weight:
90069.375
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Gene Name:
NME1
Uniprot ID:
P15531
Molecular weight:
17148.635
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Gene Name:
NME7
Uniprot ID:
Q9Y5B8
Molecular weight:
42491.365
General function:
Involved in oxidoreductase activity
Specific function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Gene Name:
RRM2
Uniprot ID:
P31350
Molecular weight:
44877.25
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
Gene Name:
NME2
Uniprot ID:
P22392
Molecular weight:
30136.92

Only showing the first 10 proteins. There are 135 proteins in total.