Cannabis Compound Database: Showing Compound Card for Guanosine diphosphate (CDB005095)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (75) Show 135 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 19:08:49 UTC

Updated at

2020-12-07 19:11:34 UTC

CannabisDB ID

CDB005095

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Guanosine diphosphate

Description

Guanosine diphosphate, also known as 5'-GDP or 5'-diphosphate, guanosine, belongs to the class of organic compounds known as purine ribonucleoside diphosphates. These are purine ribobucleotides with diphosphate group linked to the ribose moiety. Guanosine diphosphate is a moderately basic compound (based on its pKa). Guanosine diphosphate exists in all living species, ranging from bacteria to humans. In humans, guanosine diphosphate is involved in intracellular signalling through adenosine receptor A2B and adenosine. Outside of the human body, Guanosine diphosphate has been detected, but not quantified in, several different foods, such as devilfish, java plums, green beans, almonds, and orange mints. This could make guanosine diphosphate a potential biomarker for the consumption of these foods. A purine ribonucleoside 5'-diphosphate resulting from the formal condensation of the hydroxy group at the 5' position of guanosine with pyrophosphoric acid. Guanosine diphosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Guanosine 5'-diphosphate	ChEBI
Guanosine 5'-diphosphoric acid	Generator
Guanosine diphosphoric acid	Generator
5'-GDP	HMDB
GDP	HMDB
Guanosine 5'-(trihydrogen pyrophosphate)	HMDB
Guanosine 5'-pyrophosphate	HMDB
Guanosine mono(trihydrogen diphosphate)	HMDB
Guanosine pyrophosphate	HMDB
Guanosine-5'-diphosphate	HMDB
Guanosine-diphosphate	HMDB
PpG	HMDB
5'-Diphosphate, guanosine	HMDB
Diphosphate, guanosine 5'-trihydrogen	HMDB
Guanosine 5' diphosphate	HMDB
Guanosine 5' trihydrogen diphosphate	HMDB
5'-Trihydrogen diphosphate, guanosine	HMDB
Diphosphate, guanosine	HMDB
Guanosine 5'-trihydrogen diphosphate	HMDB

Chemical Formula

C₁₀H₁₅N₅O₁₁P₂

Average Molecular Weight

443.2

Monoisotopic Molecular Weight

443.0243

IUPAC Name

[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid

Traditional Name

{[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl}oxyphosphonic acid

CAS Registry Number

146-91-8

SMILES

NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1

InChI Identifier

InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1

InChI Key

QGWNDRXFNXRZMB-UUOKFMHZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as purine ribonucleoside diphosphates. These are purine ribobucleotides with diphosphate group linked to the ribose moiety.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Purine nucleotides

Sub Class

Purine ribonucleotides

Direct Parent

Purine ribonucleoside diphosphates

Alternative Parents

Substituents

Purine ribonucleoside diphosphate
Purine ribonucleoside monophosphate
Pentose phosphate
Pentose-5-phosphate
Glycosyl compound
N-glycosyl compound
6-oxopurine
Hypoxanthine
Monosaccharide phosphate
Organic pyrophosphate
Pentose monosaccharide
Imidazopyrimidine
Purine
Aminopyrimidine
Monoalkyl phosphate
Pyrimidone
Monosaccharide
N-substituted imidazole
Organic phosphoric acid derivative
Alkyl phosphate
Phosphoric acid ester
Pyrimidine
Vinylogous amide
Tetrahydrofuran
Azole
Imidazole
Heteroaromatic compound
Secondary alcohol
1,2-diol
Organoheterocyclic compound
Azacycle
Oxacycle
Organooxygen compound
Organic nitrogen compound
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Alcohol
Amine
Organic oxygen compound
Primary amine
Organonitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

purine ribonucleoside 5'-diphosphate (CHEBI:17552 )
guanosine 5'-phosphate (CHEBI:17552 )
Ribonucleotides (C00035 )

Ontology

Physiological effect

Health effect:

Health condition:

Nervous system disorders:

Stroke

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Plant:

Animal

Biological location:

Biofluid and excreta:

Subcellular:

Cell and elements:

Extracellular

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-1.5	ALOGPS
logP	-3.7	ChemAxon
logS	-2	ALOGPS
pKa (Strongest Acidic)	1.71	ChemAxon
pKa (Strongest Basic)	2.55	ChemAxon
Physiological Charge	-3	ChemAxon
Hydrogen Acceptor Count	13	ChemAxon
Hydrogen Donor Count	7	ChemAxon
Polar Surface Area	248.28 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	85.93 m³·mol⁻¹	ChemAxon
Polarizability	34.74 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	Guanosine diphosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-004i-5930200000-bdc0893316c12636a495	Spectrum
Predicted GC-MS	Guanosine diphosphate, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0229-6393250000-a57b7f18975223fa888c	Spectrum
Predicted GC-MS	Guanosine diphosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0udl-0900600000-5c7173a5771dfefadc5e	Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0udi-0900000000-d38af29994fa5108c331	Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0udi-0900000000-3072d857dcc8a1b2cbaa	Spectrum
MS/MS	LC-MS/MS Spectrum - , negative	splash10-0kdi-5901100000-24a5c807e53370f01d0c	Spectrum
MS/MS	LC-MS/MS Spectrum - , positive	splash10-0udi-0900000000-6399eaf97235815c4cb7	Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Positive	splash10-0udi-0900000000-80f8e0b42526cc03fef4	Spectrum
MS/MS	LC-MS/MS Spectrum - 30V, Negative	splash10-0pdl-2902100000-027fb059218f84756c35	Spectrum
MS/MS	LC-MS/MS Spectrum - 30V, Negative	splash10-0pdl-2902200000-876f01fe6b2be177ac75	Spectrum
MS/MS	LC-MS/MS Spectrum - 30V, Negative	splash10-0pdl-3902100000-054557b6d17ed830f7e5	Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9600000000-2f85040f9b280383ec8a	Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-054o-5904800000-e39f64dcf91afa144498	Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-0006-0001900000-cdce5e7d8986462632b2	Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Negative	splash10-0kdi-5901100000-ba4bded631640c110a56	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0udi-0911300000-fcd49d8a5e9d3dc3f933	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-0900000000-ded96f0f499982ac1ab0	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0udi-0900000000-ac93e95f54842f42e273	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0f6x-0900800000-1ed1199fdace4d1b4d80	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0zir-3900000000-b9aeef613c34fe99a48c	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9200000000-f630c9237e72a76d3d63	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0udi-0900200000-fa2d42f6050d9ab60119	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-0900000000-ed3d09503a04c850d595	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0udi-0900000000-19a5699334c495daa4e5	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0006-0001900000-7b9b9276c5e39c703f8c	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-004i-9202300000-fa0fbdc8c265ee49a371	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9100000000-278ab542160fff840256	Spectrum

NMR

Type	Description	View
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
2D NMR	[1H,1H] 2D NMR Spectrum	Spectrum
2D NMR	[1H,13C] 2D NMR Spectrum	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Citric Acid Cycle
Gluconeogenesis
Purine Metabolism
Aspartate Metabolism
Canavan Disease		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleoside triphosphate diphosphohydrolase 1	ENTPD1	10q24	P49961	details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Ectonucleoside triphosphate diphosphohydrolase 3	ENTPD3	3p21.3	O75355	details
Uridine-cytidine kinase 1	UCK1	9q34.13	Q9HA47	details
Nucleoside diphosphate kinase, mitochondrial	NME4	16p13.3	O00746	details
Ribonucleoside-diphosphate reductase large subunit	RRM1	11p15.5	P23921	details
Nucleoside diphosphate kinase A	NME1	17q21.3	P15531	details
Nucleoside diphosphate kinase 7	NME7	1q24	Q9Y5B8	details
Ribonucleoside-diphosphate reductase subunit M2	RRM2	2p25-p24	P31350	details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
Nucleoside diphosphate kinase 3	NME3	16q13.3	Q13232	details
Nucleoside diphosphate kinase 6	NME6	3p21	O75414	details
Fucose-1-phosphate guanylyltransferase	FPGT	1p31.1	O14772	details
Alpha-1,3/1,6-mannosyltransferase ALG2	ALG2	9q22.33	Q9H553	details
Dolichol-phosphate mannosyltransferase	DPM1	20q13.13	O60762	details
GDP-mannose 4,6 dehydratase	GMDS	6p25	O60547	details
Galactoside 2-alpha-L-fucosyltransferase 2	FUT2	19q13.3	Q10981	details
Galactoside 2-alpha-L-fucosyltransferase 1	FUT1	19q13.3	P19526	details
6-phosphofructokinase type C	PFKP	10p15.3-p15.2	Q01813	details
6-phosphofructokinase, liver type	PFKL	21q22.3	P17858	details
6-phosphofructokinase, muscle type	PFKM	12q13.3	P08237	details
Pyruvate kinase isozymes M1/M2	PKM	15q22	P14618	details
Pyruvate kinase isozymes R/L	PKLR	1q21	P30613	details
Ectonucleoside triphosphate diphosphohydrolase 4	ENTPD4	8p21.3	Q9Y227	details
Ectonucleoside triphosphate diphosphohydrolase 6	ENTPD6	20p11.21	O75354	details
Ectonucleoside triphosphate diphosphohydrolase 5	ENTPD5	14q24	O75356	details
Adenylosuccinate synthetase isozyme 2	ADSS	1q44	P30520	details
Adenylosuccinate synthetase isozyme 1	ADSSL1	14q32.33	Q8N142	details
Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial	SUCLG1	2p11.2	P53597	details
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial	PCK2	14q11.2	Q16822	details
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial	SUCLG2	3p14.1	Q96I99	details
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	PCK1	20q13.31	P35558	details
GDP-L-fucose synthase	TSTA3	8q24.3	Q13630	details
Guanylate kinase	GUK1	1q32-q41	Q16774	details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial	SUCLA2	13q12.2-q13.3	Q9P2R7	details
Alpha-(1,3)-fucosyltransferase	FUT5	19p13.3	Q11128	details
Polyribonucleotide nucleotidyltransferase 1, mitochondrial	PNPT1	2p15	Q8TCS8	details
Rho guanine nucleotide exchange factor 1	ARHGEF1	19q13.13	Q92888	details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	20q13.3	P63092	details
Vinexin	SORBS3	8p21.3	O60504	details
GTPase HRas	HRAS	11p15.5	P01112	details
Guanine nucleotide-binding protein G(q) subunit alpha	GNAQ	9q21	P50148	details
Guanine nucleotide-binding protein subunit alpha-11	GNA11	19p13.3	P29992	details
Chitobiosyldiphosphodolichol beta-mannosyltransferase	ALG1	16p13.3	Q9BT22	details
Guanine nucleotide-binding protein G(t) subunit alpha-1	GNAT1	3p21	P11488	details
Uridine-cytidine kinase 2	UCK2	1q23	Q9BZX2	details
Protein ALEX	GNAS	20q13.3	P84996	details
Lysophosphatidic acid receptor 2	LPAR2	19p12	Q9HBW0	details
ENTPD4 protein	ENTPD4	8p21.3	Q8NE73	details
Mannose-1-phosphate guanyltransferase beta	GMPPB	3p21.31	Q9Y5P6	details
Mannose-1-phosphate guanyltransferase alpha	GMPPA	2q35	Q96IJ6	details
Alpha-(1,6)-fucosyltransferase	FUT8	14q24.3	Q9BYC5	details
Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	8q23.1	Q7LG56	details
Uridine-cytidine kinase-like 1	UCKL1	20q13.33	Q9NWZ5	details
Ectonucleoside triphosphate diphosphohydrolase 8	ENTPD8	9q34.3	Q5MY95	details
GTPase-activating protein and VPS9 domain-containing protein 1	GAPVD1	9q33.3	Q14C86	details
Probable E3 ubiquitin-protein ligase HERC1	HERC1	15q22	Q15751	details
Interferon-inducible GTPase 5	IRGC	19q13.31	Q6NXR0	details
MAP kinase-activating death domain protein	MADD	11p11.2	Q8WXG6	details
Putative nucleoside diphosphate kinase	NME2P1	12q24.31	O60361	details
Probable 8-oxo-dGTP diphosphatase NUDT15	NUDT15	13q14.2	Q9NV35	details
8-oxo-dGDP phosphatase NUDT18	NUDT18	8p21.3	Q6ZVK8	details
GDP-fucose protein O-fucosyltransferase 1	POFUT1	20q11	Q9H488	details
Rho-related GTP-binding protein RhoU	RHOU	1q42.11-q42.3	Q7L0Q8	details
GDP-fucose protein O-fucosyltransferase 2	POFUT2	21q22.3	Q9Y2G5	details
Protein RCC2	RCC2	1p36.13	Q9P258	details
Protein very KIND	KNDC1	10q26.3	Q76NI1	details
Nucleoside diphosphate kinase	NME4	16p13.3	A2IDD0	details
Hydroxylysine kinase	AGPHD1	15q25.1	A2RU49	details
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase	ALG11	13q14.2	Q2TAA5	details
Dolichol-phosphate mannosyltransferase subunit 3	DPM3		Q9P2X0	details
Galactoside 3(4)-L-fucosyltransferase	FUT3	19p13.3	P21217	details
GDP-D-glucose phosphorylase 1	GDPGP1	15q26.1	Q6ZNW5	details
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1	HDDC3	15q26.1	Q8N4P3	details
Nucleoside diphosphate kinase homolog 5	NME5		P56597	details

Transporters

Not Available

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Nucleoside diphosphate kinase, mitochondrial	NME4	16p13.3	O00746	details
Nucleoside diphosphate kinase 7	NME7	1q24	Q9Y5B8	details
Ribonucleoside-diphosphate reductase subunit M2	RRM2	2p25-p24	P31350	details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
Nucleoside diphosphate kinase 3	NME3	16q13.3	Q13232	details
Nucleoside diphosphate kinase 6	NME6	3p21	O75414	details
6-phosphofructokinase type C	PFKP	10p15.3-p15.2	Q01813	details
6-phosphofructokinase, liver type	PFKL	21q22.3	P17858	details
6-phosphofructokinase, muscle type	PFKM	12q13.3	P08237	details
Pyruvate kinase isozymes M1/M2	PKM	15q22	P14618	details
Pyruvate kinase isozymes R/L	PKLR	1q21	P30613	details
Adenylosuccinate synthetase isozyme 2	ADSS	1q44	P30520	details
Adenylosuccinate synthetase isozyme 1	ADSSL1	14q32.33	Q8N142	details
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial	PCK2	14q11.2	Q16822	details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial	SUCLA2	13q12.2-q13.3	Q9P2R7	details
Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	8q23.1	Q7LG56	details
Dedicator of cytokinesis protein 2	DOCK2	5q35.1	Q92608	details
Probable 8-oxo-dGTP diphosphatase NUDT15	NUDT15	13q14.2	Q9NV35	details
Ras guanyl-releasing protein 3	RASGRP3	2p25.1-p24.1	Q8IV61	details
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1	HDDC3	15q26.1	Q8N4P3	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	GNG2	14q21	P59768	details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	20q13.3	P63092	details
Guanine nucleotide-binding protein G(q) subunit alpha	GNAQ	9q21	P50148	details
Guanine nucleotide-binding protein subunit alpha-11	GNA11	19p13.3	P29992	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	GNG11	7q21	P61952	details
Guanine nucleotide-binding protein G(t) subunit alpha-1	GNAT1	3p21	P11488	details
Lysophosphatidic acid receptor 2	LPAR2	19p12	Q9HBW0	details
Alpha-(1,6)-fucosyltransferase	FUT8	14q24.3	Q9BYC5	details
Dynamin-1	DNM1	9q34	Q05193	details
Dynamin-2	DNM2	19p13.2	P50570	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	GNG10	9q31.3	P50151	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNG12	1p31.3	Q9UBI6	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNG13	16p13.3	Q9P2W3	details
Guanine nucleotide-binding protein G(T) subunit gamma-T1	GNGT1	7q21.3	P63211	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	GNG3	11p11	P63215	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	GNG4	1q42.3	P50150	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	GNG5	1p22	P63218	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	GNG7	19p13.3	O60262	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNG8	19q13.32	Q9UK08	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	GNGT2	17q21	O14610	details
T-lymphoma invasion and metastasis-inducing protein 2	TIAM2	6q25.2	Q8IVF5	details
Guanine nucleotide-binding protein G(i) subunit alpha-1	GNAI1	7q21	P63096	details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	GNAS	20q13.3	Q5JWF2	details
Guanine nucleotide-binding protein subunit alpha-14	GNA14	9q21	O95837	details
Guanine nucleotide-binding protein G(k) subunit alpha	GNAI3	1p13	P08754	details
Guanine nucleotide-binding protein G(i) subunit alpha-2	GNAI2	3p21	P04899	details
Guanine nucleotide-binding protein G(t) subunit alpha-2	GNAT2	1p13.1	P19087	details
Guanine nucleotide-binding protein G(o) subunit alpha	GNAO1	16q13	P09471	details
Guanine nucleotide-binding protein subunit alpha-13	GNA13	17q24.3	Q14344	details
Guanine nucleotide binding protein (G protein), alpha 14	GNA14	9q21	B1ALW3	details
Guanine nucleotide-binding protein subunit alpha-12	GNA12	7p22.2	Q03113	details
Growth factor receptor-bound protein 2	GRB2	17q24-q25	P62993	details
Guanine nucleotide binding protein (G protein), q polypeptide	GNAQ	9q21	B1AM21	details
Guanine nucleotide-binding protein G(z) subunit alpha	GNAZ	22q11.22	P19086	details
Guanine nucleotide-binding protein G(olf) subunit alpha	GNAL	18p11.22-p11.21	P38405	details
Guanine nucleotide-binding protein subunit alpha-15	GNA15	19p13.3	P30679	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ribonucleoside-diphosphate reductase subunit M2	RRM2	2p25-p24	P31350	details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
Dynamin-2	DNM2	19p13.2	P50570	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0001201

DrugBank ID

DB04315

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB030875

KNApSAcK ID

Not Available

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

Guanosine diphosphate

METLIN ID

6077

PubChem Compound

8977

PDB ID

Not Available

ChEBI ID

17552

References

General References

Not Available

Only showing the first 10 proteins. There are 135 proteins in total.

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Enzymes

Enzyme Details

1. Ectonucleoside triphosphate diphosphohydrolase 1

General function:: Involved in hydrolase activity
Specific function:: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:: ENTPD1
Uniprot ID:: P49961
Molecular weight:: 58706.0

Enzyme Details

2. Soluble calcium-activated nucleotidase 1

General function:: Involved in calcium ion binding
Specific function:: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:: CANT1
Uniprot ID:: Q8WVQ1
Molecular weight:: 44839.24

Enzyme Details

3. Ectonucleoside triphosphate diphosphohydrolase 3

General function:: Involved in hydrolase activity
Specific function:: Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:: ENTPD3
Uniprot ID:: O75355
Molecular weight:: 59104.76

Enzyme Details

4. Uridine-cytidine kinase 1

General function:: Involved in ATP binding
Specific function:: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Gene Name:: UCK1
Uniprot ID:: Q9HA47
Molecular weight:: 22760.43

Enzyme Details

5. Nucleoside diphosphate kinase, mitochondrial

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).
Gene Name:: NME4
Uniprot ID:: O00746
Molecular weight:: 20658.45

Enzyme Details

6. Ribonucleoside-diphosphate reductase large subunit

General function:: Involved in oxidation reduction
Specific function:: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Gene Name:: RRM1
Uniprot ID:: P23921
Molecular weight:: 90069.375

Enzyme Details

7. Nucleoside diphosphate kinase A

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Gene Name:: NME1
Uniprot ID:: P15531
Molecular weight:: 17148.635

Enzyme Details

8. Nucleoside diphosphate kinase 7

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Gene Name:: NME7
Uniprot ID:: Q9Y5B8
Molecular weight:: 42491.365

Enzyme Details

9. Ribonucleoside-diphosphate reductase subunit M2

General function:: Involved in oxidoreductase activity
Specific function:: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Gene Name:: RRM2
Uniprot ID:: P31350
Molecular weight:: 44877.25

Enzyme Details

10. Nucleoside diphosphate kinase B

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
Gene Name:: NME2
Uniprot ID:: P22392
Molecular weight:: 30136.92

Only showing the first 10 proteins. There are 135 proteins in total.

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Showing Compound Card for Guanosine diphosphate (CDB005095)

Structure for CDB005095 (Guanosine diphosphate)

Enzymes