Identification |
HMDB Protein ID
| CDBP00451 |
Secondary Accession Numbers
| Not Available |
Name
| Galactoside 2-alpha-L-fucosyltransferase 1 |
Description
| Not Available |
Synonyms
|
- Alpha(1,2)FT 1
- Blood group H alpha 2-fucosyltransferase
- Fucosyltransferase 1
- GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
|
Gene Name
| FUT1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in galactoside 2-alpha-L-fucosyltransferase activity |
Specific Function
| Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.
|
GO Classification
|
Biological Process |
L-fucose catabolic process |
protein glycosylation |
Cellular Component |
Golgi cisterna membrane |
Golgi apparatus |
integral to plasma membrane |
Component |
membrane |
golgi apparatus |
cell part |
organelle |
membrane-bounded organelle |
intracellular membrane-bounded organelle |
Function |
catalytic activity |
transferase activity |
transferase activity, transferring hexosyl groups |
transferase activity, transferring glycosyl groups |
fucosyltransferase activity |
alpha(1,2)-fucosyltransferase activity |
galactoside 2-alpha-l-fucosyltransferase activity |
Molecular Function |
galactoside 2-alpha-L-fucosyltransferase activity |
Process |
metabolic process |
primary metabolic process |
carbohydrate metabolic process |
|
Cellular Location
|
- Single-pass type II membrane protein
- Golgi apparatus
- Golgi stack membrane
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | protein glycosylation | Not Available | Not Available | Glycosphingolipid biosynthesis - lacto and neolacto series | Not Available | ![Map00601](https://www.genome.jp/kegg/misc/thumbnail/map00601.gif) | Glycosphingolipid biosynthesis - globo series | Not Available | ![Map00603](https://www.genome.jp/kegg/misc/thumbnail/map00603.gif) |
|
Gene Properties |
Chromosome Location
| 19 |
Locus
| 19q13.3 |
SNPs
| FUT1 |
Gene Sequence
|
>1098 bp
ATGTGGCTCCGGAGCCATCGTCAGCTCTGCCTGGCCTTCCTGCTAGTCTGTGTCCTCTCT
GTAATCTTCTTCCTCCATATCCATCAAGACAGCTTTCCACATGGCCTAGGCCTGTCGATC
CTGTGTCCAGACCGCCGCCTGGTGACACCCCCAGTGGCCATCTTCTGCCTGCCGGGTACT
GCGATGGGCCCCAACGCCTCCTCTTCCTGTCCCCAGCACCCTGCTTCCCTCTCCGGCACC
TGGACTGTCTACCCCAATGGCCGGTTTGGTAATCAGATGGGACAGTATGCCACGCTGCTG
GCTCTGGCCCAGCTCAACGGCCGCCGGGCCTTTATCCTGCCTGCCATGCATGCCGCCCTG
GCCCCGGTATTCCGCATCACCCTGCCCGTGCTGGCCCCAGAAGTGGACAGCCGCACGCCG
TGGCGGGAGCTGCAGCTTCACGACTGGATGTCGGAGGAGTACGCGGACTTGAGAGATCCT
TTCCTGAAGCTCTCTGGCTTCCCCTGCTCTTGGACTTTCTTCCACCATCTCCGGGAACAG
ATCCGCAGAGAGTTCACCCTGCACGACCACCTTCGGGAAGAGGCGCAGAGTGTGCTGGGT
CAGCTCCGCCTGGGCCGCACAGGGGACCGCCCGCGCACCTTTGTCGGCGTCCACGTGCGC
CGTGGGGACTATCTGCAGGTTATGCCTCAGCGCTGGAAGGGTGTGGTGGGCGACAGCGCC
CACCTCCGGCAGGCCATGGACTGGTTCCGGGCACGGCACGAAGCCCCCGTTTTCGTGGTC
ACCAGCAACGGCATGGAGTGGTGTAAAGAAAACATCGACACCTCCCAGGGCGATGTGACG
TTTGCTGGCGATGGACAGGAGGCTACACCGTGGAAAGACTTTGCCCTGCTCACACAGTGC
AACCACACCATTATGACCATTGGCACCTTCGGCTTCTGGGCTGCCTACCTGGCTGGCGGA
GACACTGTCTACCTGGCCAACTTCACCCTGCCAGACTCTGAGTTCCTGAAGATCTTTAAG
CCGGAGGCGGCCTTCCTGCCCGAGTGGGTGGGCATTAATGCAGACTTGTCTCCACTCTGG
ACATTGGCTAAGCCTTGA
|
Protein Properties |
Number of Residues
| 365 |
Molecular Weight
| 41251.11 |
Theoretical pI
| 7.355 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Galactoside 2-alpha-L-fucosyltransferase 1
MWLRSHRQLCLAFLLVCVLSVIFFLHIHQDSFPHGLGLSILCPDRRLVTPPVAIFCLPGT
AMGPNASSSCPQHPASLSGTWTVYPNGRFGNQMGQYATLLALAQLNGRRAFILPAMHAAL
APVFRITLPVLAPEVDSRTPWRELQLHDWMSEEYADLRDPFLKLSGFPCSWTFFHHLREQ
IRREFTLHDHLREEAQSVLGQLRLGRTGDRPRTFVGVHVRRGDYLQVMPQRWKGVVGDSA
YLRQAMDWFRARHEAPVFVVTSNGMEWCKENIDTSQGDVTFAGDGQEATPWKDFALLTQC
NHTIMTIGTFGFWAAYLAGGDTVYLANFTLPDSEFLKIFKPEAAFLPEWVGINADLSPLW
TLAKP
|
External Links |
GenBank ID Protein
| 2217925 |
UniProtKB/Swiss-Prot ID
| P19526 |
UniProtKB/Swiss-Prot Entry Name
| FUT1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AB004861 |
GeneCard ID
| FUT1 |
GenAtlas ID
| FUT1 |
HGNC ID
| HGNC:4012 |
References |
General References
| Not Available |