| Identification |
|---|
| HMDB Protein ID
| CDBP00868 |
| Secondary Accession Numbers
| Not Available |
| Name
| GDP-L-fucose synthase |
| Description
| Not Available |
| Synonyms
|
- GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase
- Protein FX
- Red cell NADP(H)-binding protein
- Short-chain dehydrogenase/reductase family 4E member 1
|
| Gene Name
| TSTA3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
|
| GO Classification
|
| Biological Process |
| GDP-mannose metabolic process |
| 'de novo' GDP-L-fucose biosynthetic process |
| cytolysis |
| leukocyte cell-cell adhesion |
| Cellular Component |
| cytoplasm |
| Function |
| binding |
| catalytic activity |
| coenzyme binding |
| cofactor binding |
| Molecular Function |
| GDP-L-fucose synthase activity |
| nucleotide binding |
| coenzyme binding |
| electron carrier activity |
| isomerase activity |
| GDP-4-dehydro-D-rhamnose reductase activity |
| Process |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Fructose and Mannose Degradation |    |  | | GDP-L-fucose biosynthesis via de novo pathway | Not Available | Not Available | | Fructose and mannose metabolism | Not Available | | | Amino sugar and nucleotide sugar metabolism | Not Available |  | | Fructosuria |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8q24.3 |
| SNPs
| TSTA3 |
| Gene Sequence
|
>966 bp
ATGGGTGAACCCCAGGGATCCATGCGGATTCTAGTGACAGGGGGCTCTGGGCTGGTAGGC
AAAGCCATCCAGAAGGTGGTAGCAGATGGAGCTGGACTTCCTGGAGAGGACTGGGTGTTT
GTCTCCTCTAAAGACGCCGATCTCACGGATACAGCACAGACCCGCGCCCTGTTTGAGAAG
GTCCAACCCACACACGTCATCCATCTTGCTGCAATGGTGGGGGGCCTGTTCCGGAATATC
AAATACAATTTGGACTTCTGGAGGAAAAACGTGCACATGAACGACAACGTCCTGCACTCG
GCCTTTGAGGTGGGGGCCCGCAAGGTGGTGTCCTGCCTGTCCACCTGTATCTTCCCTGAC
AAGACGACCTACCCGATAGATGAGACCATGATCCACAATGGGCCTCCCCACAACAGCAAT
TTTGGGTACTCGTATGCCAAGAGGATGATCGACGTGCAGAACAGGGCCTACTTCCAGCAG
TACGGCTGCACCTTCACCGCTGTCATCCCCACCAACGTTTTCGGGCCCCACGACAACTTC
AACATCGAGGATGGCCACGTGCTGCCTGGCCTCATCCACAAGGTGCACCTGGCCAAGAGC
AGCGGCTCGGCCCTGACGGTGTGGGGTACAGGGAATCCGCGGAGGCAGTTCATATACTCG
CTGGACCTGGCCCAGCTCTTTATCTGGGTCCTGCGGGAGTACAATGAAGTGGAGCCCATC
ATCCTCTCCGTGGGCGAGGAAGATGAGGTCTCCATCAAGGAGGCAGCCGAGGCGGTGGTG
GAGGCCATGGACTTCCATGGGGAAGTCACCTTTGATACAACCAAGTCGGATGGGCAGTTT
AAGAAGACAGCCAGTAACAGCAAGCTGAGGACCTACCTGCCCGACTTCCGGTTCACACCC
TTCAAGCAGGCGGTGAAGGAGACCTGTGCTTGGTTCACTGACAACTACGAGCAGGCCCGG
AAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 321 |
| Molecular Weight
| 35892.46 |
| Theoretical pI
| 6.6 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>GDP-L-fucose synthase
MGEPQGSMRILVTGGSGLVGKAIQKVVADGAGLPGEDWVFVSSKDADLTDTAQTRALFEK
VQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHMNDNVLHSAFEVGARKVVSCLSTCIFPD
KTTYPIDETMIHNGPPHNSNFGYSYAKRMIDVQNRAYFQQYGCTFTAVIPTNVFGPHDNF
NIEDGHVLPGLIHKVHLAKSSGSALTVWGTGNPRRQFIYSLDLAQLFIWVLREYNEVEPI
ILSVGEEDEVSIKEAAEAVVEAMDFHGEVTFDTTKSDGQFKKTASNSKLRTYLPDFRFTP
FKQAVKETCAWFTDNYEQARK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q13630 |
| UniProtKB/Swiss-Prot Entry Name
| FCL_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| U58766 |
| GeneCard ID
| TSTA3 |
| GenAtlas ID
| TSTA3 |
| HGNC ID
| HGNC:12390 |
| References |
|---|
| General References
| Not Available |