Identification |
HMDB Protein ID
| CDBP00375 |
Secondary Accession Numbers
| Not Available |
Name
| Alpha-1,3/1,6-mannosyltransferase ALG2 |
Description
| Not Available |
Synonyms
|
- Asparagine-linked glycosylation protein 2 homolog
- GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase
- GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
- GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
|
Gene Name
| ALG2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in biosynthetic process |
Specific Function
| Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.
|
GO Classification
|
Biological Process |
protein glycosylation in endoplasmic reticulum |
response to calcium ion |
dolichol-linked oligosaccharide biosynthetic process |
post-translational protein modification |
protein N-linked glycosylation via asparagine |
Cellular Component |
endoplasmic reticulum membrane |
perinuclear region of cytoplasm |
nucleus |
integral to membrane |
Molecular Function |
alpha-1,3-mannosyltransferase activity |
calcium-dependent protein binding |
GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity |
protein anchor |
Process |
metabolic process |
biosynthetic process |
|
Cellular Location
|
- Membrane
- Single-pass membrane protein (Potential)
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | protein glycosylation | Not Available | Not Available | N-Glycan biosynthesis | Not Available | ![Map00510](https://www.genome.jp/kegg/misc/thumbnail/map00510.gif) |
|
Gene Properties |
Chromosome Location
| 9 |
Locus
| 9q22.33 |
SNPs
| ALG2 |
Gene Sequence
|
>1251 bp
ATGGCGGAGGAGCAGGGCCGGGAACGGGACTCGGTTCCCAAGCCGTCGGTGCTGTTCCTC
CACCCAGACCTGGGCGTGGGCGGCGCTGAGCGGCTGGTGTTGGACGCGGCGCTGGCGCTG
CAGGCGCGCGGGTGTAGCGTGAAGATCTGGACAGCGCACTACGACCCGGGCCACTGTTTC
GCCGAGAGCCGCGAGCTACCGGTGCGCTGTGCCGGGGACTGGCTGCCGCGAGGCCTGGGC
TGGGGCGGCCGCGGCGCCGCCGTCTGCGCCTACGTGCGCATGGTTTTCCTGGCGCTCTAC
GTGCTGTTCCTCGCCGACGAGGAGTTCGACGTGGTAGTGTGCGACCAGGTGTCTGCCTGT
ATCCCAGTGTTCAGGCTGGCTAGACGGCGGAAGAAGATCCTATTTTACTGTCACTTCCCA
GATCTGCTTCTCACCAAGAGAGATTCTTTTCTTAAACGACTATACAGGGCCCCAATTGAC
TGGATAGAGGAATACACCACAGGCATGGCAGACTGCATCTTAGTCAACAGCCAGTTCACA
GCTGCTGTTTTTAAGGAAACATTCAAGTCCCTGTCTCACATAGACCCTGATGTCCTCTAT
CCATCTCTAAATGTCACCAGCTTTGACTCAGTTGTTCCTGAAAAGCTGGATGACCTAGTC
CCCAAGGGGAAAAAATTCCTGCTGCTCTCCATCAACAGATACGAAAGGAAGAAAAATCTG
ACTTTGGCACTGGAAGCCCTAGTACAGCTGCGTGGAAGATTGACATCCCAAGATTGGGAG
AGGGTTCATCTGATCGTGGCAGGTGGTTATGACGAGAGAGTCCTGGAGAATGTGGAACAT
TATCAGGAATTGAAGAAAATGGTCCAACAGTCCGACCTTGGCCAGTATGTGACCTTCTTG
AGGTCTTTCTCAGACAAACAGAAAATCTCCCTCCTCCACAGCTGCACGTGTGTGCTTTAC
ACACCAAGCAATGAGCACTTTGGCATTGTCCCTCTGGAAGCCATGTACATGCAGTGCCCA
GTCATTGCTGTTAATTCGGGTGGACCCTTGGAGTCCATTGACCACAGTGTCACAGGGTTT
CTGTGTGAGCCTGACCCGGTGCACTTCTCAGAAGCAATAGAAAAGTTCATCCGTGAACCT
TCCTTAAAAGCCACCATGGGCCTGGCTGGAAGAGCCAGAGTGAAGGAAAAATTTTCCCCT
GAAGCATTTACAGAACAGCTCTACCGATATGTTACCAAACTGCTGGTATAA
|
Protein Properties |
Number of Residues
| 416 |
Molecular Weight
| 47091.075 |
Theoretical pI
| 7.047 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Alpha-1,3-mannosyltransferase ALG2
MAEEQGRERDSVPKPSVLFLHPDLGVGGAERLVLDAALALQARGCSVKIWTAHYDPGHCF
AESRELPVRCAGDWLPRGLGWGGRGAAVCAYVRMVFLALYVLFLADEEFDVVVCDQVSAC
IPVFRLARRRKKILFYCHFPDLLLTKRDSFLKRLYRAPIDWIEEYTTGMADCILVNSQFT
AAVFKETFKSLSHIDPDVLYPSLNVTSFDSVVPEKLDDLVPKGKKFLLLSINRYERKKNL
TLALEALVQLRGRLTSQDWERVHLIVAGGYDERVLENVEHYQELKKMVQQSDLGQYVTFL
RSFSDKQKISLLHSCTCVLYTPSNEHFGIVPLEAMYMQCPVIAVNSGGPLESIDHSVTGF
LCEPDPVHFSEAIEKFIREPSLKATMGLAGRARVKEKFSPEAFTEQLYRYVTKLLV
|
External Links |
GenBank ID Protein
| 44885912 |
UniProtKB/Swiss-Prot ID
| Q9H553 |
UniProtKB/Swiss-Prot Entry Name
| ALG2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AB161356 |
GeneCard ID
| ALG2 |
GenAtlas ID
| ALG2 |
HGNC ID
| HGNC:23159 |
References |
General References
| Not Available |