Identification |
HMDB Protein ID
| CDBP05291 |
Secondary Accession Numbers
| Not Available |
Name
| Galactoside 3(4)-L-fucosyltransferase |
Description
| Not Available |
Synonyms
|
- Blood group Lewis alpha-4-fucosyltransferase
- Fucosyltransferase 3
- Fucosyltransferase III
- Lewis FT
- FucT-III
|
Gene Name
| FUT3 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Not Available |
Specific Function
| May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.
|
GO Classification
|
Biological Process |
oligosaccharide biosynthetic process |
cell-cell recognition |
macromolecule glycosylation |
protein glycosylation |
Cellular Component |
Golgi cisterna membrane |
membrane |
integral to membrane |
Molecular Function |
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity |
alpha-(1->3)-fucosyltransferase activity |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | protein glycosylation | Not Available | Not Available | Glycosphingolipid biosynthesis - lacto and neolacto series | Not Available | ![Map00601](https://www.genome.jp/kegg/misc/thumbnail/map00601.gif) |
|
Gene Properties |
Chromosome Location
| 19 |
Locus
| 19p13.3 |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 42116.69 |
Theoretical pI
| 9.006 |
Pfam Domain Function
|
Not Available |
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>gi|4503809|ref|NP_000140.1| galactoside 3(4)-L-fucosyltransferase [Homo sapiens]
MDPLGAAKPQWPWRRCLAALLFQLLVAVCFFSYLRVSRDDATGSPRAPSGSSRQDTTPTR
PTLLILLWTW
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P21217 |
UniProtKB/Swiss-Prot Entry Name
| Not Available |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| HGNC:4014 |
References |
General References
| Not Available |