Cannabis Compound Database: Showing Compound Card for Astragalin (CDB000793)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (42)transporters (1) Show 98 proteins XML

Record Information

Version

1.0

Created at

2020-03-19 00:57:20 UTC

Updated at

2020-12-07 19:07:46 UTC

CannabisDB ID

CDB000793

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Astragalin

Description

Kaempferol 3-O-beta-D-glucoside also known as astragalin, is a kaempferol O-glucoside in which the glucosyl residue is attached at position 3 of kaempferol via a beta-glycosidic linkage. Astragalin has been isolated from many different plants and plant families including members of the Fabaceae, Convolvulaceae, Ebenaceae, Rosaceae and Eucommiaceae families. This compound is well known for its diverse pharmacological applications such as anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties (PMID: 29853868 ). It appears to carry out these activities by the regulation and modulation of various molecular targets such as transcription factors (NF-Œ∫B, TNF-Œ±, and TGF-Œ≤1), enzymes (iNOS, COX-2, PGE2, MMP-1, MMP-3, MIP-1Œ±, COX-2, PGE-2, HK2, AChe, SOD, DRP-1, DDH, PLC≈í‚â•1, and GPX), kinases (JNK, MAPK, Akt, ERK, SAPK, IŒ∫BŒ±, PI3K, and PKCŒ≤2), cell adhesion proteins (E-cadherin, vimentin PAR-2, and NCam), apoptotic and antiapoptotic proteins (Beclin-1, Bcl-2, Bax, Bcl-xL, cytochrome c, LC3A/B, caspase-3, caspase-9, procaspase-3, procaspase-8, and IgE), and inflammatory cytokines (SOCS-3, SOCS-5, IL-1Œ≤, IL-4, IL-6, IL-8, IL-13, MCP-1, CXCL-1, CXCL-2, and IFN-Œ≥) (PMID: 29853868 ). Astragalin was first identified in cold-pressed cannabis seed oil in 2016. (PMID: 27076277 ).

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Value	Source
3,4',5,7-Tetrahydroxyflavone-3-glucoside	ChEBI
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl beta-D-glucopyranoside	ChEBI
Astragaline	ChEBI
Kaempferol 3-O-glucoside	ChEBI
Kaempferol-3-O-beta-glucopyranoside	ChEBI
Kaempferol 3-O-beta-D-glucoside	Kegg
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl b-D-glucopyranoside	Generator
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl β-D-glucopyranoside	Generator
Kaempferol-3-O-b-glucopyranoside	Generator
Kaempferol-3-O-β-glucopyranoside	Generator
Kaempferol 3-O-b-D-glucoside	Generator
Kaempferol 3-O-β-D-glucoside	Generator
Kaempferol 3-O-beta-D-glucopyranoside	MeSH
Astragalin	ChEBI
3,4',5,7-Tetrahydroxyflavone	HMDB
3-O-b-D-Glucopyranoside	HMDB
3-O-b-D-Glucopyranosyloxy-4',5,7-trihydroxyflavone	HMDB
Asragalin	HMDB
Kaempferol 3-glucoside	HMDB
Kaempferol-3-beta-glucopyranoside	HMDB
Kaempferol-3-beta-monoglucoside	HMDB
Kaempferol-3-D-glucoside	HMDB
Kaempferol-3-glucoside	HMDB
Kaempferol-3-O-glucoside	HMDB
3-Glucosylkaempferol	PhytoBank
4',5,7-Trihydroxyflavone 3-beta-D-glucopyranoside	PhytoBank
4',5,7-Trihydroxyflavone 3-β-D-glucopyranoside	PhytoBank
4’,5,7-Trihydroxyflavone 3-β-D-glucopyranoside	PhytoBank
Kaemferol 3-O-glucopyranoside	PhytoBank
Kaempferol 3-O-glucopyranoside	PhytoBank
Kaempferol 3-O-β-D-glucopyranoside	PhytoBank
Kaempferol 3-O-beta-glucoside	PhytoBank
Kaempferol 3-O-β-glucoside	PhytoBank
Kaempferol 3-beta-D-glucopyranoside	PhytoBank
Kaempferol 3-β-D-glucopyranoside	PhytoBank
Kaempferol 3-beta-D-glucoside	PhytoBank
Kaempferol 3-β-D-glucoside	PhytoBank
Kaempherol 3-O-beta-D-glucopyranoside	PhytoBank
Kaempherol 3-O-β-D-glucopyranoside	PhytoBank

Chemical Formula

C₂₁H₂₀O₁₁

Average Molecular Weight

448.38

Monoisotopic Molecular Weight

448.1006

IUPAC Name

5,7-dihydroxy-2-(4-hydroxyphenyl)-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one

Traditional Name

astragalin

CAS Registry Number

480-10-4

SMILES

OC[C@H]1O[C@@H](OC2=C(OC3=CC(O)=CC(O)=C3C2=O)C2=CC=C(O)C=C2)[C@H](O)[C@@H](O)[C@@H]1O

InChI Identifier

InChI=1S/C21H20O11/c22-7-13-15(26)17(28)18(29)21(31-13)32-20-16(27)14-11(25)5-10(24)6-12(14)30-19(20)8-1-3-9(23)4-2-8/h1-6,13,15,17-18,21-26,28-29H,7H2/t13-,15-,17+,18-,21+/m1/s1

InChI Key

JPUKWEQWGBDDQB-QSOFNFLRSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as flavonoid-3-o-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C3-position.

Kingdom

Organic compounds

Super Class

Phenylpropanoids and polyketides

Class

Flavonoids

Sub Class

Flavonoid glycosides

Direct Parent

Flavonoid-3-O-glycosides

Alternative Parents

Substituents

Flavonoid-3-o-glycoside
4'-hydroxyflavonoid
5-hydroxyflavonoid
7-hydroxyflavonoid
Flavone
Hydroxyflavonoid
Hexose monosaccharide
Chromone
Glycosyl compound
O-glycosyl compound
Benzopyran
1-benzopyran
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Phenol
Pyranone
Pyran
Monocyclic benzene moiety
Oxane
Monosaccharide
Benzenoid
Heteroaromatic compound
Vinylogous acid
Secondary alcohol
Organoheterocyclic compound
Oxacycle
Acetal
Polyol
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Alcohol
Primary alcohol
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

monosaccharide derivative (CHEBI:30200 )
trihydroxyflavone (CHEBI:30200 )
kaempferol O-glucoside (CHEBI:30200 )
flavonols (C12249 )
Flavones and Flavonols (C12249 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Food

Biological:

Animal

Plant:

Biological location:

Subcellular:

Cytoplasm

Cell and elements:

Extracellular

Role

Industrial application:

Pharmaceutical industry:

Antineoplastic agent:

Anticancer agent

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	178 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.52	ALOGPS
logP	0.16	ChemAxon
logS	-2.4	ALOGPS
pKa (Strongest Acidic)	6.37	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	11	ChemAxon
Hydrogen Donor Count	7	ChemAxon
Polar Surface Area	186.37 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	107.29 m³·mol⁻¹	ChemAxon
Polarizability	42.39 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	Astragalin , non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0f8i-8914600000-70416132b3766fd636fb	Spectrum
Predicted GC-MS	Astragalin , 3 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0f72-4730019000-7036585c066b67f1f0ce	Spectrum
Predicted GC-MS	Astragalin , non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - ESI-TOF 10V, Negative	splash10-0iki-0930000000-20176d350f94ae4a84ed	2017-08-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 20V, Negative	splash10-0002-0020900000-182256be3fac5a878f1b	2017-08-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 30V, Negative	splash10-001i-0090100000-7bd32a5c1969c5a248ac	2017-08-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 40V, Negative	splash10-0560-0090000000-1c2e7f81b693e6297183	2017-08-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 50V, Negative	splash10-0a6r-0090000000-364026dfdcefd0d2e3a9	2017-08-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF , Negative	splash10-0002-0000900030-4139a6b8a2e916a0ea74	2017-08-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 10V, Negative	splash10-0002-0000900000-b3cdd88343725a79c5e0	2017-09-12	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 10V, Negative	splash10-0002-0000900010-9834ce03ded5a1fe8c48	2017-09-12	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 20V, Negative	splash10-0002-0020900000-182256be3fac5a878f1b	2017-09-12	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 30V, Negative	splash10-001i-0090100000-7bd32a5c1969c5a248ac	2017-09-12	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 40V, Negative	splash10-0560-0090000000-1c2e7f81b693e6297183	2017-09-12	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 50V, Negative	splash10-0a6r-0090000000-364026dfdcefd0d2e3a9	2017-09-12	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF , Negative	splash10-0002-0000900030-4139a6b8a2e916a0ea74	2017-09-12	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-052b-0090400000-98b6bb6a62f4d8812fde	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-0002-0020900010-4e6aa6edffb0c4b2f832	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-0a59-0090000000-94e191a13790b3b49952	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-0002-0000900000-1c8fa629cb5881a42933	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-055b-0090200000-269c7f2460a6f35009c8	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-0a7i-0090000000-d43f3a3dfafef985b9ef	2017-09-14	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000j-0190800000-d3b297eb0fe481caa10a	2016-06-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-0190000000-1e520254d0769f8f845e	2016-06-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-05n0-3590000000-7f6360b543570fc55716	2016-06-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-000b-1151900000-879fdf0c200d1a8caf5b	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-000i-1190200000-8b8be60a1a225937d8d8	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-000i-3590000000-22efe60043282fcdf379	2016-08-03	View Spectrum

NMR

Not Available

Pathways

Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Prostaglandin E synthase	PTGES	9q34.3	O14684	details
Aldo-keto reductase family 1 member C1	AKR1C1	10p15-p14	Q04828	details
Acetylcholinesterase	ACHE	7q22	P22303	details
Glutathione peroxidase 7	GPX7	1p32	Q96SL4	details
Epididymal secretory glutathione peroxidase	GPX5	6p22.1	O75715	details
Glutathione peroxidase 6	GPX6	6p22.1	P59796	details
Glutathione peroxidase 1	GPX1	3p21.3	P07203	details
Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	19p13.3	P36969	details
Glutathione peroxidase 3	GPX3	5q23	P22352	details
Glutathione peroxidase 2	GPX2	14q24.1	P18283	details
Nitric oxide synthase, inducible	NOS2	17q11.2-q12	P35228	details
Prostaglandin G/H synthase 2	PTGS2	1q25.2-q25.3	P35354	details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details
Mitogen-activated protein kinase 12	MAPK12	22q13.33	P53778	details
Mitogen-activated protein kinase 1	MAPK1	22q11.2\|22q11.21	P28482	details
Mitogen-activated protein kinase 7	MAPK7	17p11.2	Q13164	details
Mitogen-activated protein kinase 3	MAPK3	16p11.2	P27361	details
Mitogen-activated protein kinase 9	MAPK9	5q35	P45984	details
Mitogen-activated protein kinase 13	MAPK13	6p21.31	O15264	details
Mitogen-activated protein kinase 11	MAPK11	22q13.33	Q15759	details
Mitogen-activated protein kinase 4	MAPK4	18q21.2	P31152	details
Mitogen-activated protein kinase 6	MAPK6	15q21	Q16659	details
Mitogen-activated protein kinase 10	MAPK10	4q22.1-q23	P53779	details
Mitogen-activated protein kinase 8	MAPK8	10q11.22	P45983	details
Vimentin	VIM	10p13	P08670	details
C-C motif chemokine 2	CCL2	17q11.2-q12	P13500	details
Superoxide dismutase [Mn], mitochondrial	SOD2	6q25.3	P04179	details
Superoxide dismutase [Cu-Zn]	SOD1	21q22.11	P00441	details
Tumor necrosis factor	TNF	6p21.3	P01375	details
Interferon gamma	IFNG	12q14	P01579	details
Interleukin-1 beta	IL1B	2q14	P01584	details
Interleukin-6	IL6	7p21	P05231	details
Nuclear factor NF-kappa-B p105 subunit	NFKB1	4q24	P19838	details
Interleukin-8	IL8	4q13-q21	P10145	details
Apoptosis regulator Bcl-2	BCL2	18q21.33\|18q21.3	P10415	details
Interstitial collagenase	MMP1	11q22.3	P03956	details
Extracellular superoxide dismutase [Cu-Zn]	SOD3	4p15.2	P08294	details
Cytochrome c oxidase subunit 2	MT-CO2		P00403	details
Mitogen-activated protein kinase 15	MAPK15		Q8TD08	details
Probable glutathione peroxidase 8	GPX8	5q11.2	Q8TED1	details
Caspase-3	CASP3	4q35.1	P42574	details
Caspase-9	CASP9	1p36.21	P55211	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Nitric oxide synthase, inducible	NOS2	17q11.2-q12	P35228	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Nitric oxide synthase, inducible	NOS2	17q11.2-q12	P35228	details
Prostaglandin G/H synthase 2	PTGS2	1q25.2-q25.3	P35354	details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details
Superoxide dismutase [Mn], mitochondrial	SOD2	6q25.3	P04179	details
Superoxide dismutase [Cu-Zn]	SOD1	21q22.11	P00441	details
Interstitial collagenase	MMP1	11q22.3	P03956	details
Stromelysin-1	MMP3	11q22.3	P08254	details
Cadherin-1	CDH1	16q22.1	P12830	details
Extracellular superoxide dismutase [Cu-Zn]	SOD3	4p15.2	P08294	details
Cytochrome c oxidase subunit 2	MT-CO2		P00403	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Acetylcholinesterase	ACHE	7q22	P22303	details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details
Mitogen-activated protein kinase 12	MAPK12	22q13.33	P53778	details
Mitogen-activated protein kinase 1	MAPK1	22q11.2\|22q11.21	P28482	details
Mitogen-activated protein kinase 7	MAPK7	17p11.2	Q13164	details
Mitogen-activated protein kinase 3	MAPK3	16p11.2	P27361	details
Mitogen-activated protein kinase 9	MAPK9	5q35	P45984	details
Mitogen-activated protein kinase 13	MAPK13	6p21.31	O15264	details
Mitogen-activated protein kinase 11	MAPK11	22q13.33	Q15759	details
Mitogen-activated protein kinase 4	MAPK4	18q21.2	P31152	details
Mitogen-activated protein kinase 6	MAPK6	15q21	Q16659	details
Mitogen-activated protein kinase 10	MAPK10	4q22.1-q23	P53779	details
Mitogen-activated protein kinase 8	MAPK8	10q11.22	P45983	details
C-C motif chemokine 2	CCL2	17q11.2-q12	P13500	details
Superoxide dismutase [Cu-Zn]	SOD1	21q22.11	P00441	details
Tumor necrosis factor	TNF	6p21.3	P01375	details
Interferon gamma	IFNG	12q14	P01579	details
Interleukin-1 beta	IL1B	2q14	P01584	details
Interleukin-6	IL6	7p21	P05231	details
Interleukin-8	IL8	4q13-q21	P10145	details
Mitogen-activated protein kinase 15	MAPK15		Q8TD08	details
Growth-regulated alpha protein	CXCL1	4q13.3	P09341	details
Caspase-3	CASP3	4q35.1	P42574	details
C-X-C motif chemokine 2	CXCL2	4q13.3	P19875	details
Suppressor of cytokine signaling 5	SOCS5	2p21	O75159	details
Suppressor of cytokine signaling 3	SOCS3	17q25.3	O14543	details
Transforming growth factor beta-1 proprotein	TGFB1	19q13.2	P01137	details
Interleukin-4	IL4	5q31.1	P05112	details
Beclin-1	BECN1	17q21.31	Q14457	details
Interleukin-13	IL13	5q31.1	P35225	details
C-C motif chemokine 3	CCL3	17q12	P10147	details
Apoptosis regulator BAX	BAX	19q13.33	Q07812	details
Neural cell adhesion molecule 1	NCAM1	11q23.2	P13591	details
NF-kappa-B inhibitor alpha	NFKBIA	14q13.2	P25963	details
Proteinase-activated receptor 2	F2RL1	5q13.3	P55085	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Glutathione peroxidase 3	GPX3	5q23	P22352	details
Superoxide dismutase [Mn], mitochondrial	SOD2	6q25.3	P04179	details
Nuclear factor NF-kappa-B p105 subunit	NFKB1	4q24	P19838	details
Nuclear factor NF-kappa-B p100 subunit	NFKB2	10q24.32	Q00653	details
Transforming growth factor beta-1 proprotein	TGFB1	19q13.2	P01137	details
Interleukin-4	IL4	5q31.1	P05112	details
C-C motif chemokine 3	CCL3	17q12	P10147	details
Apoptosis regulator BAX	BAX	19q13.33	Q07812	details
NF-kappa-B inhibitor alpha	NFKBIA	14q13.2	P25963	details
Proteinase-activated receptor 2	F2RL1	5q13.3	P55085	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0037429

DrugBank ID

Not Available

Phenol Explorer Compound ID

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Not Available

Wikipedia Link

Astragalin

METLIN ID

Not Available

PubChem Compound

5282102

PDB ID

Not Available

ChEBI ID

30200

References

General References

Riaz A, Rasul A, Hussain G, Zahoor MK, Jabeen F, Subhani Z, Younis T, Ali M, Sarfraz I, Selamoglu Z: Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities. Adv Pharmacol Sci. 2018 May 2;2018:9794625. doi: 10.1155/2018/9794625. eCollection 2018. [PubMed:29853868 ]
Smeriglio A, Galati EM, Monforte MT, Lanuzza F, D'Angelo V, Circosta C: Polyphenolic Compounds and Antioxidant Activity of Cold-Pressed Seed Oil from Finola Cultivar of Cannabis sativa L. Phytother Res. 2016 Aug;30(8):1298-307. doi: 10.1002/ptr.5623. Epub 2016 Apr 14. [PubMed:27076277 ]

Only showing the first 10 proteins. There are 98 proteins in total.

Show All

Enzymes

Enzyme Details

1. Prostaglandin E synthase

General function:: Involved in prostaglandin-E synthase activity
Specific function:: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
Gene Name:: PTGES
Uniprot ID:: O14684
Molecular weight:: 17102.135

Enzyme Details

2. Aldo-keto reductase family 1 member C1

General function:: Involved in oxidoreductase activity
Specific function:: Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
Gene Name:: AKR1C1
Uniprot ID:: Q04828
Molecular weight:: 36788.02

Enzyme Details

3. Acetylcholinesterase

General function:: Involved in carboxylesterase activity
Specific function:: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Gene Name:: ACHE
Uniprot ID:: P22303
Molecular weight:: 67795.525

Enzyme Details

4. Glutathione peroxidase 7

General function:: Involved in glutathione peroxidase activity
Specific function:: It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
Gene Name:: GPX7
Uniprot ID:: Q96SL4
Molecular weight:: 20995.88

Enzyme Details

5. Epididymal secretory glutathione peroxidase

General function:: Involved in glutathione peroxidase activity
Specific function:: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
Gene Name:: GPX5
Uniprot ID:: O75715
Molecular weight:: 25202.14

Enzyme Details

6. Glutathione peroxidase 6

General function:: Involved in glutathione peroxidase activity
Specific function:: Not Available
Gene Name:: GPX6
Uniprot ID:: P59796
Molecular weight:: 24970.46

Enzyme Details

7. Glutathione peroxidase 1

General function:: Involved in glutathione peroxidase activity
Specific function:: Protects the hemoglobin in erythrocytes from oxidative breakdown.
Gene Name:: GPX1
Uniprot ID:: P07203
Molecular weight:: 22087.94

Enzyme Details

8. Phospholipid hydroperoxide glutathione peroxidase, mitochondrial

General function:: Involved in glutathione peroxidase activity
Specific function:: Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
Gene Name:: GPX4
Uniprot ID:: P36969
Molecular weight:: 25046.57

Enzyme Details

9. Glutathione peroxidase 3

General function:: Involved in glutathione peroxidase activity
Specific function:: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Gene Name:: GPX3
Uniprot ID:: P22352
Molecular weight:: 25552.185

Enzyme Details

10. Glutathione peroxidase 2

General function:: Involved in glutathione peroxidase activity
Specific function:: Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
Gene Name:: GPX2
Uniprot ID:: P18283
Molecular weight:: 21953.835

Transporters

Enzyme Details

1. Nitric oxide synthase, inducible

General function:: Involved in oxidoreductase activity
Specific function:: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Gene Name:: NOS2
Uniprot ID:: P35228
Molecular weight:: 131116.3

Only showing the first 10 proteins. There are 98 proteins in total.

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Showing Compound Card for Astragalin (CDB000793)

Structure for CDB000793 (Astragalin )

Enzymes

Transporters