| Identification |
|---|
| HMDB Protein ID
| CDBP00774 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phospholipid hydroperoxide glutathione peroxidase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- GPx-4
- GSHPx-4
- Glutathione peroxidase 4
- PHGPx
|
| Gene Name
| GPX4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutathione peroxidase activity |
| Specific Function
| Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
|
| GO Classification
|
| Biological Process |
| phospholipid metabolic process |
| response to oxidative stress |
| multicellular organismal development |
| Cellular Component |
| mitochondrion |
| Function |
| peroxidase activity |
| antioxidant activity |
| glutathione peroxidase activity |
| Molecular Function |
| glutathione peroxidase activity |
| phospholipid-hydroperoxide glutathione peroxidase activity |
| Process |
| response to stimulus |
| response to stress |
| response to oxidative stress |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Cytoplasm
- Mitochondrion
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.3 |
| SNPs
| GPX4 |
| Gene Sequence
|
>594 bp
ATGAGCCTCGGCCGCCTTTGCCGCCTACTGAAGCCGGCGCTGCTCTGTGGGGCTCTGGCC
GCGCCTGGCCTGGCCGGGACCATGTGCGCGTCCCGGGACGACTGGCGCTGTGCGCGCTCC
ATGCACGAGTTTTCCGCCAAGGACATCGACGGGCACATGGTTAACCTGGACAAGTACCGG
GGCTTCGTGTGCATCGTCACCAACGTGGCCTCCCAGTGAGGCAAGACCGAAGTAAACTAC
ACTCAGCTCGTCGACCTGCACGCCCGATACGCTGAGTGTGGTTTGCGGATCCTGGCCTTC
CCGTGTAACCAGTTCGGGAAGCAGGAGCCAGGGAGTAACGAAGAGATCAAAGAGTTCGCC
GCGGGCTACAACGTCAAATTCGATATGTTCAGCAAGATCTGCGTGAACGGGGACGACGCC
CACCCGCTGTGGAAGTGGATGAAGATCCAACCCAAGGGCAAGGGCATCCTGGGAAATGCC
ATCAAGTGGAACTTCACCAAGTTCCTCATCGACAAGAACGGCTGCGTGGTGAAGCGCTAC
GGACCCATGGAGGAGCCCCTGGTGATAGAGAAGGACCTGCCCCACTATTTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 197 |
| Molecular Weight
| 25046.57 |
| Theoretical pI
| 9.083 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phospholipid hydroperoxide glutathione peroxidase, mitochondrial
MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR
GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA
AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRY
GPMEEPLVIEKDLPHYF
|
| External Links |
|---|
| GenBank ID Protein
| 825667 |
| UniProtKB/Swiss-Prot ID
| P36969 |
| UniProtKB/Swiss-Prot Entry Name
| GPX4_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X71973 |
| GeneCard ID
| GPX4 |
| GenAtlas ID
| GPX4 |
| HGNC ID
| HGNC:4556 |
| References |
|---|
| General References
| Not Available |