| Identification |
|---|
| HMDB Protein ID
| CDBP01780 |
| Secondary Accession Numbers
| Not Available |
| Name
| Interleukin-6 |
| Description
| Not Available |
| Synonyms
|
- B-cell stimulatory factor 2
- BSF-2
- CDF
- CTL differentiation factor
- Hybridoma growth factor
- IFN-beta-2
- IL-6
- Interferon beta-2
|
| Gene Name
| IL6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cytokine activity |
| Specific Function
| Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance |
| GO Classification
|
| Component |
| extracellular region |
| Function |
| cytokine activity |
| binding |
| cytokine receptor binding |
| interleukin-6 receptor binding |
| protein binding |
| receptor binding |
| Process |
| immune system process |
| immune response |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7p21 |
| SNPs
| IL6 |
| Gene Sequence
|
>639 bp
ATGAACTCCTTCTCCACAAGCGCCTTCGGTCCAGTTGCCTTCTCCCTGGGGCTGCTCCTG
GTGTTGCCTGCTGCCTTCCCTGCCCCAGTACCCCCAGGAGAAGATTCCAAAGATGTAGCC
GCCCCACACAGACAGCCACTCACCTCTTCAGAACGAATTGACAAACAAATTCGGTACATC
CTCGACGGCATCTCAGCCCTGAGAAAGGAGACATGTAACAAGAGTAACATGTGTGAAAGC
AGCAAAGAGGCACTGGCAGAAAACAACCTGAACCTTCCAAAGATGGCTGAAAAAGATGGA
TGCTTCCAATCTGGATTCAATGAGGAGACTTGCCTGGTGAAAATCATCACTGGTCTTTTG
GAGTTTGAGGTATACCTAGAGTACCTCCAGAACAGATTTGAGAGTAGTGAGGAACAAGCC
AGAGCTGTCCAGATGAGTACAAAAGTCCTGATCCAGTTCCTGCAGAAAAAGGCAAAGAAT
CTAGATGCAATAACCACCCCTGACCCAACCACAAATGCCAGCCTGCTGACGAAGCTGCAG
GCACAGAACCAGTGGCTGCAGGACATGACAACTCATCTCATTCTGCGCAGCTTTAAGGAG
TTCCTGCAGTCCAGCCTGAGGGCTCTTCGGCAAATGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 212 |
| Molecular Weight
| 23718.0 |
| Theoretical pI
| 6.52 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Interleukin-6
MNSFSTSAFGPVAFSLGLLLVLPAAFPAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYI
LDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLL
EFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQ
AQNQWLQDMTTHLILRSFKEFLQSSLRALRQM
|
| External Links |
|---|
| GenBank ID Protein
| 32674 |
| UniProtKB/Swiss-Prot ID
| P05231 |
| UniProtKB/Swiss-Prot Entry Name
| IL6_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X04430 |
| GeneCard ID
| IL6 |
| GenAtlas ID
| IL6 |
| HGNC ID
| HGNC:6018 |
| References |
|---|
| General References
| Not Available |