| Identification |
|---|
| HMDB Protein ID
| CDBP00498 |
| Secondary Accession Numbers
| Not Available |
| Name
| Acetylcholinesterase |
| Description
| Not Available |
| Synonyms
|
- AChE
|
| Gene Name
| ACHE |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in carboxylesterase activity |
| Specific Function
| Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
|
| GO Classification
|
| Biological Process |
| cell adhesion |
| retina development in camera-type eye |
| cell proliferation |
| synapse assembly |
| choline metabolic process |
| protein tetramerization |
| DNA replication |
| muscle organ development |
| negative regulation of synaptic transmission, cholinergic |
| neurotransmitter biosynthetic process |
| neurotransmitter receptor biosynthetic process |
| osteoblast development |
| phosphatidylcholine biosynthetic process |
| positive regulation of protein secretion |
| receptor internalization |
| regulation of axonogenesis |
| regulation of dendrite morphogenesis |
| acetylcholine catabolic process in synaptic cleft |
| regulation of receptor recycling |
| amyloid precursor protein metabolic process |
| response to wounding |
| Cellular Component |
| nucleus |
| extracellular space |
| axon |
| cell surface |
| anchored to membrane |
| plasma membrane |
| basal lamina |
| cell junction |
| dendrite |
| endoplasmic reticulum lumen |
| Golgi apparatus |
| neuromuscular junction |
| perinuclear region of cytoplasm |
| postsynaptic membrane |
| presynaptic membrane |
| synaptic cleft |
| Component |
| membrane |
| cell part |
| Function |
| cholinesterase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| carboxylesterase activity |
| Molecular Function |
| serine hydrolase activity |
| protein homodimerization activity |
| acetylcholine binding |
| acetylcholinesterase activity |
| beta-amyloid binding |
| collagen binding |
| laminin binding |
| carboxylesterase activity |
|
| Cellular Location
|
- Lipid-anchor
- Extracellular side
- Isoform H:Cell membrane
- GPI- anchor
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Phospholipid Biosynthesis |    |  | | Glycerophospholipid metabolism | Not Available | | | Cholinergic synapse | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7q22 |
| SNPs
| ACHE |
| Gene Sequence
|
>1845 bp
ATGAGGCCCCCGCAGTGTCTGCTGCACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTC
CTCCTCTGGCTCCTGGGTGGAGGAGTGGGGGCTGAGGGCCGGGAGGATGCAGAGCTGCTG
GTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCCTGTC
TCTGCTTTCCTGGGCATCCCCTTTGCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCA
CCGGAGCCCAAGCAGCCTTGGTCAGGGGTGGTAGACGCTACAACCTTCCAGAGTGTCTGC
TACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCCCAAC
CGTGAGCTGAGCGAGGACTGCCTGTACCTCAACGTGTGGACACCATACCCCCGGCCTACA
TCCCCCACCCCTGTCCTCGTCTGGATCTATGGGGGTGGCTTCTACAGTGGGGCCTCCTCC
TTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTCCATG
AACTACCGGGTGGGAGCCTTTGGCTTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGC
AATGTGGGTCTCCTGGATCAGAGGCTGGCCCTGCAGTGGGTGCAGGAGAACGTGGCAGCC
TTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTCGGTG
GGCATGCACCTGCTGTCCCCGCCCAGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGC
GGTGCCCCCAATGGACCCTGGGCCACGGTGGGCATGGGAGAGGCCCGTCGCAGGGCCACG
CAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGAGCTG
GTAGCCTGCCTTCGGACACGACCAGCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTG
CCTCAAGAAAGCGTCTTCCGGTTCTCCTTCGTGCCTGTGGTAGATGGAGACTTCCTCAGT
GACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGGTGCTGGTGGGT
GTGGTGAAGGATGAGGGCTCGTATTTTCTGGTTTACGGGGCCCCAGGCTTCAGCAAAGAC
AACGAGTCTCTCATCAGCCGGGCCGAGTTCCTGGCCGGGGTGCGGGTCGGGGTTCCCCAG
GTAAGTGACCTGGCAGCCGAGGCTGTGGTCCTGCATTACACAGACTGGCTGCATCCCGAG
GACCCGGCACGCCTGAGGGAGGCCCTGAGCGATGTGGTGGGCGACCACAATGTCGTGTGC
CCCGTGGCCCAGCTGGCTGGGCGACTGGCTGCCCAGGGTGCCCGGGTCTACGCCTACGTC
TTTGAACACCGTGCTTCCACGCTCTCCTGGCCCCTGTGGATGGGGGTGCCCCACGGCTAC
GAGATCGAGTTCATCTTTGGGATCCCCCTGGACCCCTCTCGAAACTACACGGCAGAGGAG
AAAATCTTCGCCCAGCGACTGATGCGATACTGGGCCAACTTTGCCCGCACAGGGGATCCC
AATGAGCCCCGAGACCCCAAGGCCCCACAATGGCCCCCGTACACGGCGGGGGCTCAGCAG
TACGTTAGTCTGGACCTGCGGCCGCTGGAGGTGCGGCGGGGGCTGCGCGCCCAGGCCTGC
GCCTTCTGGAACCGCTTCCTCCCCAAATTGCTCAGCGCCACCGACACGCTCGACGAGGCG
GAGCGCCAGTGGAAGGCCGAGTTCCACCGCTGGAGCTCCTACATGGTGCACTGGAAGAAC
CAGTTCGACCACTACAGCAAGCAGGATCGCTGCTCAGACCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 614 |
| Molecular Weight
| 67795.525 |
| Theoretical pI
| 6.291 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Acetylcholinesterase
MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQDRCSDL
|
| External Links |
|---|
| GenBank ID Protein
| 177975 |
| UniProtKB/Swiss-Prot ID
| P22303 |
| UniProtKB/Swiss-Prot Entry Name
| ACES_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| M55040 |
| GeneCard ID
| ACHE |
| GenAtlas ID
| ACHE |
| HGNC ID
| HGNC:108 |
| References |
|---|
| General References
| Not Available |