499 CDBP00498 Acetylcholinesterase P22303 ACES_HUMAN true false Enzyme Homo_sapiens ACHE 614 67795.525 6.291 Involved in carboxylesterase activity Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis. 1B41;1F8U;1PUV;1PUW;1VZJ;2CLJ;2X8B;3LII;4EY4;4EY5;4EY6;4EY7;4EY8 M55040 177975 ACHE 7 7q22 ACHE HGNC:108 true hsa:43 NP_000656.1:NM_000665.3;NP_056646.1:NM_015831.2 Isoform H is highly expressed in erythrocytes. Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers . Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers. Isoform R may be monomeric 2020-06-12T23:06:50Z 2020-07-28T02:25:30Z 1 0 0