| Identification |
|---|
| HMDB Protein ID
| CDBP00755 |
| Secondary Accession Numbers
| Not Available |
| Name
| Epididymal secretory glutathione peroxidase |
| Description
| Not Available |
| Synonyms
|
- EGLP
- Epididymis-specific glutathione peroxidase-like protein
- GPx-5
- GSHPx-5
- Glutathione peroxidase 5
|
| Gene Name
| GPX5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutathione peroxidase activity |
| Specific Function
| Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
|
| GO Classification
|
| Biological Process |
| response to oxidative stress |
| lipid metabolic process |
| Cellular Component |
| extracellular region |
| Function |
| peroxidase activity |
| antioxidant activity |
| glutathione peroxidase activity |
| Molecular Function |
| glutathione peroxidase activity |
| Process |
| response to stimulus |
| response to stress |
| response to oxidative stress |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| 6p22.1 |
| SNPs
| GPX5 |
| Gene Sequence
|
>666 bp
ATGACTACACAGTTAAGGGTCGTCCATCTGCTTCCCCTTCTCCTAGCCTGCTTTGTGCAA
ACAAGTCCCAAGCAGGAGAAGATGAAGATGGATTGCCACAAAGACGAGAAAGGCACCATC
TATGACTATGAGGCCATCGCACTTAATAAGAATGAATATGTTTCCTTCAAGCAGTATGTG
GGCAAGCACATCCTCTTCGTCAACGTGGCCACCTACTGTGGTCTGACAGCGCAATATCCT
GAACTAAATGCACTCCAGGAGGAGCTGAAGCCCTATGGTCTAGTTGTGTTGGGCTTTCCC
TGCAACCAATTTGGAAAGCAAGAACCAGGAGATAACAAAGAGATTCTTCCTGGGCTCAAG
TATGTCCGTCCAGGGGGAGGATTTGTACCTAGTTTCCAGCTTTTTGAGAAAGGGGATGTG
AATGGTGAAAAAGAACAGAAAGTCTTCAGTTTCTTGAAGCACTCCTGTCCTCATCCCTCT
GAGATTTTGGGCACATTCAAATCTATATCCTGGGACCCTGTAAAGGTCCATGACATCCGT
TGGAACTTTGAAAAGTTCCTGGTGGGGCCTGATGGAATCCCTGTCATGCGCTGGTCCCAC
CGGGCTACGGTCAGCTCAGTCAAGACAGACATCCTGGCGTACTTGAAGCAATTCAAAACC
AAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 221 |
| Molecular Weight
| 25202.14 |
| Theoretical pI
| 8.64 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Epididymal secretory glutathione peroxidase
MTTQLRVVHLLPLLLACFVQTSPKQEKMKMDCHKDEKGTIYDYEAIALNKNEYVSFKQYV
GKHILFVNVATYCGLTAQYPELNALQEELKPYGLVVLGFPCNQFGKQEPGDNKEILPGLK
YVRPGGGFVPSFQLFEKGDVNGEKEQKVFSFLKHSCPHPSEILGTFKSISWDPVKVHDIR
WNFEKFLVGPDGIPVMRWSHRATVSSVKTDILAYLKQFKTK
|
| External Links |
|---|
| GenBank ID Protein
| 3288455 |
| UniProtKB/Swiss-Prot ID
| O75715 |
| UniProtKB/Swiss-Prot Entry Name
| GPX5_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AJ005277 |
| GeneCard ID
| GPX5 |
| GenAtlas ID
| GPX5 |
| HGNC ID
| HGNC:4557 |
| References |
|---|
| General References
| Not Available |