| Identification |
|---|
| HMDB Protein ID
| CDBP01656 |
| Secondary Accession Numbers
| Not Available |
| Name
| C-C motif chemokine 2 |
| Description
| Not Available |
| Synonyms
|
- HC11
- MCAF
- MCP-1
- Monocyte chemoattractant protein 1
- Monocyte chemotactic and activating factor
- Monocyte chemotactic protein 1
- Monocyte secretory protein JE
- Small-inducible cytokine A2
|
| Gene Name
| CCL2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chemokine activity |
| Specific Function
| Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis |
| GO Classification
|
| Component |
| extracellular region |
| Function |
| chemokine activity |
| binding |
| protein binding |
| receptor binding |
| cytokine activity |
| Process |
| immune system process |
| immune response |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q11.2-q12 |
| SNPs
| CCL2 |
| Gene Sequence
|
>300 bp
ATGAAAGTCTCTGCCGCCCTTCTGTGCCTGCTGCTCATAGCAGCCACCTTCATTCCCCAA
GGGCTCGCTCAGCCAGATGCAATCAATGCCCCAGTCACCTGCTGTTATAACTTCACCAAT
AGGAAGATCTCAGTGCAGAGGCTCGCGAGCTATAGAAGAATCACCAGCAGCAAGTGTCCC
AAAGAAGCTGTGATCTTCAAGACCATTGTGGCCAAGGAGATCTGTGCTGACCCCAAGCAG
AAGTGGGTTCAGGATTCCATGGACCACCTGGACAAGCAAACCCAAACTCCGAAGACTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 99 |
| Molecular Weight
| 11024.9 |
| Theoretical pI
| 9.72 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>C-C motif chemokine 2
MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCP
KEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
|
| External Links |
|---|
| GenBank ID Protein
| 641145 |
| UniProtKB/Swiss-Prot ID
| P13500 |
| UniProtKB/Swiss-Prot Entry Name
| CCL2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| A17786 |
| GeneCard ID
| CCL2 |
| GenAtlas ID
| CCL2 |
| HGNC ID
| HGNC:10618 |
| References |
|---|
| General References
| Not Available |