Identification
HMDB Protein ID CDBP01946
Secondary Accession Numbers Not Available
Name Apoptosis regulator Bcl-2
Description Not Available
Synonyms Not Available
Gene Name BCL2
Protein Type Enzyme
Biological Properties
General Function Involved in regulation of apoptosis
Specific Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1)
GO Classification
Component
membrane
cell part
Process
regulation of biological process
regulation of cell death
regulation of programmed cell death
regulation of apoptosis
regulation of cellular process
biological regulation
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Single-pass membrane protein
  3. Single-pass membrane protein
  4. Single-pass membrane protein
  5. Mitochondrion outer membrane
  6. Nucleus membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 18q21.33|18q21.3
SNPs BCL2
Gene Sequence
>720 bp
ATGGCGCACGCTGGGAGAACAGGGTACGATAACCGGGAGATAGTGATGAAGTACATCCAT
TATAAGCTGTCGCAGAGGGGCTACGAGTGGGATGCGGGAGATGTGGGCGCCGCGCCCCCG
GGGGCCGCCCCCGCACCGGGCATCTTCTCCTCCCAGCCCGGGCACACGCCCCATCCAGCC
GCATCCCGGGACCCGGTCGCCAGGACCTCGCCGCTGCAGACCCCGGCTGCCCCCGGCGCC
GCCGCGGGGCCTGCGCTCAGCCCGGTGCCACCTGTGGTCCACCTGACCCTCCGCCAGGCC
GGCGACGACTTCTCCCGCCGCTACCGCCGCGACTTCGCCGAGATGTCCAGCCAGCTGCAC
CTGACGCCCTTCACCGCGCGGGGACGCTTTGCCACGGTGGTGGAGGAGCTCTTCAGGGAC
GGGGTGAACTGGGGGAGGATTGTGGCCTTCTTTGAGTTCGGTGGGGTCATGTGTGTGGAG
AGCGTCAACCGGGAGATGTCGCCCCTGGTGGACAACATCGCCCTGTGGATGACTGAGTAC
CTGAACCGGCACCTGCACACCTGGATCCAGGATAACGGAGGCTGGGATGCCTTTGTGGAA
CTGTACGGCCCCAGCATGCGGCCTCTGTTTGATTTCTCCTGGCTGTCTCTGAAGACTCTG
CTCAGTTTGGCCCTGGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGGGCCACAAGTGA
Protein Properties
Number of Residues 239
Molecular Weight 26265.7
Theoretical pI 7.32
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["212-233"]
Protein Sequence
>Apoptosis regulator Bcl-2
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
GenBank ID Protein 28144173
UniProtKB/Swiss-Prot ID P10415
UniProtKB/Swiss-Prot Entry Name BCL2_HUMAN
PDB IDs Not Available
GenBank Gene ID AY220759
GeneCard ID BCL2
GenAtlas ID BCL2
HGNC ID HGNC:990
References
General References Not Available