Identification |
HMDB Protein ID
| CDBP01946 |
Secondary Accession Numbers
| Not Available |
Name
| Apoptosis regulator Bcl-2 |
Description
| Not Available |
Synonyms
|
Not Available
|
Gene Name
| BCL2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in regulation of apoptosis |
Specific Function
| Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) |
GO Classification
|
Component |
membrane |
cell part |
Process |
regulation of biological process |
regulation of cell death |
regulation of programmed cell death |
regulation of apoptosis |
regulation of cellular process |
biological regulation |
|
Cellular Location
|
- Endoplasmic reticulum membrane
- Single-pass membrane protein
- Single-pass membrane protein
- Single-pass membrane protein
- Mitochondrion outer membrane
- Nucleus membrane
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 18q21.33|18q21.3 |
SNPs
| BCL2 |
Gene Sequence
|
>720 bp
ATGGCGCACGCTGGGAGAACAGGGTACGATAACCGGGAGATAGTGATGAAGTACATCCAT
TATAAGCTGTCGCAGAGGGGCTACGAGTGGGATGCGGGAGATGTGGGCGCCGCGCCCCCG
GGGGCCGCCCCCGCACCGGGCATCTTCTCCTCCCAGCCCGGGCACACGCCCCATCCAGCC
GCATCCCGGGACCCGGTCGCCAGGACCTCGCCGCTGCAGACCCCGGCTGCCCCCGGCGCC
GCCGCGGGGCCTGCGCTCAGCCCGGTGCCACCTGTGGTCCACCTGACCCTCCGCCAGGCC
GGCGACGACTTCTCCCGCCGCTACCGCCGCGACTTCGCCGAGATGTCCAGCCAGCTGCAC
CTGACGCCCTTCACCGCGCGGGGACGCTTTGCCACGGTGGTGGAGGAGCTCTTCAGGGAC
GGGGTGAACTGGGGGAGGATTGTGGCCTTCTTTGAGTTCGGTGGGGTCATGTGTGTGGAG
AGCGTCAACCGGGAGATGTCGCCCCTGGTGGACAACATCGCCCTGTGGATGACTGAGTAC
CTGAACCGGCACCTGCACACCTGGATCCAGGATAACGGAGGCTGGGATGCCTTTGTGGAA
CTGTACGGCCCCAGCATGCGGCCTCTGTTTGATTTCTCCTGGCTGTCTCTGAAGACTCTG
CTCAGTTTGGCCCTGGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGGGCCACAAGTGA
|
Protein Properties |
Number of Residues
| 239 |
Molecular Weight
| 26265.7 |
Theoretical pI
| 7.32 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Apoptosis regulator Bcl-2
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
|
External Links |
GenBank ID Protein
| 28144173 |
UniProtKB/Swiss-Prot ID
| P10415 |
UniProtKB/Swiss-Prot Entry Name
| BCL2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AY220759 |
GeneCard ID
| BCL2 |
GenAtlas ID
| BCL2 |
HGNC ID
| HGNC:990 |
References |
General References
| Not Available |