| Identification |
|---|
| HMDB Protein ID
| CDBP00754 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glutathione peroxidase 7 |
| Description
| Not Available |
| Synonyms
|
- CL683
- GPx-7
- GSHPx-7
|
| Gene Name
| GPX7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glutathione peroxidase activity |
| Specific Function
| It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
|
| GO Classification
|
| Biological Process |
| response to oxidative stress |
| Cellular Component |
| extracellular region |
| Function |
| antioxidant activity |
| glutathione peroxidase activity |
| peroxidase activity |
| Molecular Function |
| glutathione peroxidase activity |
| Process |
| response to stimulus |
| response to stress |
| response to oxidative stress |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Secreted (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p32 |
| SNPs
| GPX7 |
| Gene Sequence
|
>564 bp
ATGGTGGCGGCGACGGTGGCAGCGGCGTGGCTGCTCCTGTGGGCTGCGGCCTGCGCGCAG
CAGGAGCAGGACTTCTACGACTTCAAGGCGGTCAACATCCGGGGCAAACTGGTGTCGCTG
GAGAAGTACCGCGGATCGGTGTCCCTGGTGGTGAATGTGGCCAGCGAGTGCGGCTTCACA
GACCAGCACTACCGAGCCCTGCAGCAGCTGCAGCGAGACCTGGGCCCCCACCACTTTAAC
GTGCTCGCCTTCCCCTGCAACCAGTTTGGCCAACAGGAGCCTGACAGCAACAAGGAGATT
GAGAGCTTTGCCCGCCGCACCTACAGTGTCTCATTCCCCATGTTTAGCAAGATTGCAGTC
ACCGGTACTGGTGCCCATCCTGCCTTCAAGTACCTGGCCCAGACTTCTGGGAAGGAGCCC
ACCTGGAACTTCTGGAAGTACCTAGTAGCCCCAGATGGAAAGGTGGTAGGGGCTTGGGAC
CCAACTGTGTCAGTGGAGGAGGTCAGACCCCAGATCACAGCGCTCGTGAGGAAGCTCATC
CTACTGAAGCGAGAAGACTTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 187 |
| Molecular Weight
| 20995.88 |
| Theoretical pI
| 8.268 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutathione peroxidase 7
MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFT
DQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAV
TGTGAHPAFKYLAQTSGKEPTWNFWKYLVAPDGKVVGAWDPTVSVEEVRPQITALVRKLI
LLKREDL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q96SL4 |
| UniProtKB/Swiss-Prot Entry Name
| GPX7_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF320068 |
| GeneCard ID
| GPX7 |
| GenAtlas ID
| GPX7 |
| HGNC ID
| HGNC:4559 |
| References |
|---|
| General References
| Not Available |