Identification
HMDB Protein ID CDBP05646
Secondary Accession Numbers Not Available
Name Apoptosis regulator BAX
Description Not Available
Synonyms Not Available
Gene Name BAX
Protein Type Enzyme
Biological Properties
General Function protein homodimerization activity
Specific Function Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
GO Classification
Biological Process
B cell negative selection
apoptotic process
mitochondrial fusion
extrinsic apoptotic signaling pathway in absence of ligand
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
cerebral cortex development
retinal cell programmed cell death
B cell receptor apoptotic signaling pathway
negative regulation of neuron apoptotic process
kidney development
extrinsic apoptotic signaling pathway
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
extrinsic apoptotic signaling pathway via death domain receptors
cellular response to unfolded protein
myeloid cell homeostasis
negative regulation of protein binding
positive regulation of release of sequestered calcium ion into cytosol
regulation of nitrogen utilization
intrinsic apoptotic signaling pathway
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
neuron apoptotic process
response to toxin
release of matrix enzymes from mitochondria
vagina development
ectopic germ cell programmed cell death
positive regulation of apoptotic process involved in mammary gland involution
release of cytochrome c from mitochondria
Sertoli cell proliferation
apoptotic mitochondrial changes
endoplasmic reticulum calcium ion homeostasis
homeostasis of number of cells within a tissue
positive regulation of protein complex assembly
spermatid differentiation
T cell homeostatic proliferation
cellular response to UV
establishment or maintenance of transmembrane electrochemical gradient
negative regulation of fibroblast proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
thymocyte apoptotic process
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of apoptotic signaling pathway
mitochondrial fragmentation involved in apoptotic process
response to axon injury
reduction of endoplasmic reticulum calcium ion concentration
negative regulation of mitochondrial membrane potential
positive regulation of intrinsic apoptotic signaling pathway
positive regulation of neuron apoptotic process
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of apoptotic DNA fragmentation
positive regulation of release of cytochrome c from mitochondria
transcription initiation from RNA polymerase II promoter
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
apoptotic signaling pathway
germ cell development
positive regulation of B cell apoptotic process
response to gamma radiation
glycosphingolipid metabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
regulation of mammary gland epithelial cell proliferation
viral reproduction
positive regulation of developmental pigmentation
response to salt stress
negative regulation of peptidyl-serine phosphorylation
apoptotic process involved in blood vessel morphogenesis
positive regulation of apoptotic process
regulation of apoptotic process
positive regulation of endoplasmic reticulum unfolded protein response
regulation of mitochondrial membrane potential
ovarian follicle development
apoptotic process involved in embryonic digit morphogenesis
mitochondrion morphogenesis
odontogenesis of dentin-containing tooth
positive regulation of IRE1-mediated unfolded protein response
retina development in camera-type eye
B cell apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
fertilization
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
hypothalamus development
B cell homeostatic proliferation
development of secondary sexual characteristics
blood vessel remodeling
B cell homeostasis
post-embryonic camera-type eye morphogenesis
neuron migration
Cellular Component
endoplasmic reticulum
mitochondrion
extracellular vesicular exosome
BAK complex
nucleus
BAX complex
nuclear envelope
Bcl-2 family protein complex
mitochondrial outer membrane
mitochondrial permeability transition pore complex
membrane
pore complex
endoplasmic reticulum membrane
cytosol
cell
cytoplasm
Molecular Function
lipid binding
BH3 domain binding
chaperone binding
channel activity
protein homodimerization activity
identical protein binding
Hsp70 protein binding
protein heterodimerization activity
Cellular Location
  1. Cytoplasm
  2. Mitochondrion outer membrane
Pathways
Gene Properties
Chromosome Location 19
Locus 19q13.33
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 221
Molecular Weight 21184.235
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • ["172-192"]
Protein Sequence
>Apoptosis regulator BAX
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLS
ECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKL
VLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGV
LTASLTIWKKMG
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q07812
UniProtKB/Swiss-Prot Entry Name BAX_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:959
References
General References Not Available