Cannabis Compound Database: Showing Protein Tumor necrosis factor (CDBP01766)

Identification Biological properties Gene properties Protein properties External links References XML Show 14 compounds

Identification

HMDB Protein ID

CDBP01766

Secondary Accession Numbers

Not Available

Name

Tumor necrosis factor

Description

Not Available

Synonyms

Cachectin
TNF-a
TNF-alpha
Tumor necrosis factor ligand superfamily member 2
Tumor necrosis factor, membrane form
Tumor necrosis factor, soluble form

Gene Name

TNF

Protein Type

Enzyme

Biological Properties

General Function

Involved in tumor necrosis factor receptor binding

Specific Function

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation

GO Classification

Component
membrane
cell part
Function
binding
cytokine receptor binding
tumor necrosis factor receptor superfamily binding
tumor necrosis factor receptor binding
protein binding
receptor binding
Process
immune response
immune system process

Cellular Location

Tumor necrosis factor
soluble form:Secreted

Pathways

Name	SMPDB/Pathwhiz	KEGG
Fc Epsilon Receptor I Signaling in Mast Cells		Not Available

Gene Properties

Chromosome Location

Chromosome:6

Locus

6p21.3

SNPs

TNF

Gene Sequence

>702 bp
ATGAGCACTGAAAGCATGATCCGGGACGTGGAGCTGGCCGAGGAGGCGCTCCCCAAGAAG
ACAGGGGGGCCCCAGGGCTCCAGGCGGTGCTTGTTCCTCAGCCTCTTCTCCTTCCTGATC
GTGGCAGGCGCCACCACGCTCTTCTGCCTGCTGCACTTTGGAGTGATCGGCCCCCAGAGG
GAAGAGTTCCCCAGGGACCTCTCTCTAATCAGCCCTCTGGCCCAGGCAGTCAGATCATCT
TCTCGAACCCCGAGTGACAAGCCTGTAGCCCATGTTGTAGCAAACCCTCAAGCTGAGGGG
CAGCTCCAGTGGCTGAACCGCCGGGCCAATGCCCTCCTGGCCAATGGCGTGGAGCTGAGA
GATAACCAGCTGGTGGTGCCATCAGAGGGCCTGTACCTCATCTACTCCCAGGTCCTCTTC
AAGGGCCAAGGCTGCCCCTCCACCCATGTGCTCCTCACCCACACCATCAGCCGCATCGCC
GTCTCCTACCAGACCAAGGTCAACCTCCTCTCTGCCATCAAGAGCCCCTGCCAGAGGGAG
ACCCCAGAGGGGGCTGAGGCCAAGCCCTGGTATGAGCCCATCTATCTGGGAGGGGTCTTC
CAGCTGGAGAAGGGTGACCGACTCAGCGCTGAGATCAATCGGCCCGACTATCTCGACTTT
GCCGAGTCTGGGCAGGTCTACTTTGGGATCATTGCCCTGTGA

Protein Properties

Number of Residues

233

Molecular Weight

25644.1

Theoretical pI

6.92

Pfam Domain Function

TNF (PF00229 )

Signals

["None"]

Transmembrane Regions

["36-56"]

Protein Sequence

>Tumor necrosis factor
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL

External Links

GenBank ID Protein

37220

UniProtKB/Swiss-Prot ID

P01375

UniProtKB/Swiss-Prot Entry Name

TNFA_HUMAN

PDB IDs