Identification
HMDB Protein ID CDBP05656
Secondary Accession Numbers Not Available
Name NF-kappa-B inhibitor alpha
Description Not Available
Synonyms Not Available
Gene Name NFKBIA
Protein Type Enzyme
Biological Properties
General Function ubiquitin protein ligase binding
Specific Function Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
GO Classification
Biological Process
cytoplasmic sequestering of transcription factor
apoptotic process
negative regulation of lipid storage
negative regulation of apoptotic process
negative regulation of myeloid cell differentiation
positive regulation of inflammatory response
nucleotide-binding oligomerization domain containing 1 signaling pathway
response to exogenous dsRNA
interleukin-1-mediated signaling pathway
nucleotide-binding oligomerization domain containing 2 signaling pathway
I-kappaB kinase/NF-kappaB cascade
regulation of NIK/NF-kappaB signaling
positive regulation of cellular protein metabolic process
response to muramyl dipeptide
negative regulation of NF-kappaB transcription factor activity
response to muscle stretch
viral reproduction
tumor necrosis factor-mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
negative regulation of Notch signaling pathway
negative regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol efflux
protein deubiquitination
lipopolysaccharide-mediated signaling pathway
toll-like receptor 4 signaling pathway
negative regulation of DNA binding
cellular response to cold
protein import into nucleus
regulation of cell proliferation
cytoplasmic sequestering of NF-kappaB
Cellular Component
cytosol
cytoplasm
plasma membrane
nucleus
nucleoplasm
I-kappaB/NF-kappaB complex
Molecular Function
transcription factor binding
enzyme binding
identical protein binding
ubiquitin protein ligase binding
NF-kappaB binding
nuclear localization sequence binding
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location 14
Locus 14q13.2
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 317
Molecular Weight 35608.65
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>NF-kappa-B inhibitor alpha
MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVP
RGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVI
TNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATN
YNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCG
ADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTE
DELPYDDCVFGGQRLTL
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P25963
UniProtKB/Swiss-Prot Entry Name IKBA_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:7797
References
General References Not Available