Showing Protein Interleukin-8 (CDBP01909)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP01909
Secondary Accession Numbers Not Available
Name Interleukin-8
Description Not Available
Synonyms
  1. (Ala-IL-8)77
  2. (Ser-IL-8)72
  3. C-X-C motif chemokine 8
  4. Emoctakin
  5. GCP-1
  6. GCP/IL-8 protein I
  7. GCP/IL-8 protein II
  8. GCP/IL-8 protein III
  9. GCP/IL-8 protein IV
  10. GCP/IL-8 protein V
  11. GCP/IL-8 protein VI
  12. Granulocyte chemotactic protein 1
  13. IL-8
  14. IL-8(1-77)
  15. IL-8(5-77)
  16. IL-8(6-77)
  17. IL-8(7-77)
  18. IL-8(8-77)
  19. IL-8(9-77)
  20. IL8/NAP1 form I
  21. IL8/NAP1 form II
  22. IL8/NAP1 form III
  23. IL8/NAP1 form IV
  24. IL8/NAP1 form V
  25. IL8/NAP1 form VI
  26. Interleukin-8
  27. LYNAP
  28. Lymphocyte-derived neutrophil-activating factor
  29. MDNCF
  30. MDNCF-a
  31. MDNCF-b
  32. MDNCF-c
  33. MONAP
  34. Monocyte-derived neutrophil chemotactic factor
  35. Monocyte-derived neutrophil-activating peptide
  36. NAF
  37. NAP-1
  38. Neutrophil-activating factor
  39. Neutrophil-activating protein 1
  40. Protein 3-10C
  41. T-cell chemotactic factor
Gene Name IL8
Protein Type Enzyme
Biological Properties
General Function Involved in cytokine activity
Specific Function IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively
GO Classification
Component
extracellular region
Function
chemokine activity
binding
protein binding
receptor binding
cytokine activity
Process
immune system process
immune response
Cellular Location
  1. Secreted
Pathways
Gene Properties
Chromosome Location Chromosome:4
Locus 4q13-q21
SNPs IL8
Gene Sequence 
>300 bp
ATGACTTCCAAGCTGGCCGTGGCTCTCTTGGCAGCCTTCCTGATTTCTGCAGCTCTGTGT
GAAGGTGCAGTTTTGCCAAGGAGTGCTAAAGAACTTAGATGTCAGTGCATAAAGACATAC
TCCAAACCTTTCCACCCCAAATTTATCAAAGAACTGAGAGTGATTGAGAGTGGACCACAC
TGCGCCAACACAGAAATTATTGTAAAGCTTTCTGATGGAAGAGAGCTCTGTCTGGACCCC
AAGGAAAACTGGGTGCAGAGGGTTGTGGAGAAGTTTTTGAAGAGGGCTGAGAATTCATAA
Protein Properties
Number of Residues 99
Molecular Weight 11098.0
Theoretical pI 9.09
Pfam Domain Function
Signals
  • ["1-20"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Interleukin-8
MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPH
CANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P10145
UniProtKB/Swiss-Prot Entry Name IL8_HUMAN
PDB IDs
GenBank Gene ID M17017
GeneCard ID IL8
GenAtlas ID IL8
HGNC ID HGNC:6025
References
General References Not Available