Showing Protein Interleukin-4 (CDBP05630)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP05630
Secondary Accession Numbers Not Available
Name Interleukin-4
Description Not Available
Synonyms Not Available
Gene Name IL4
Protein Type Enzyme
Biological Properties
General Function interleukin-4 receptor binding
Specific Function Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity).
GO Classification
Biological Process
dendritic cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of T cell differentiation
macrophage activation
cytokine-mediated signaling pathway
regulation of immune response
myeloid dendritic cell differentiation
regulation of phosphorylation
regulation of isotype switching
negative regulation of complement-dependent cytotoxicity
negative regulation of osteoclast differentiation
T-helper 2 cell cytokine production
positive regulation of cell migration
positive regulation of cell proliferation
negative regulation of endothelial cell apoptotic process
positive regulation of gene expression
type 2 immune response
negative regulation of apoptotic process
negative regulation of epithelial cell migration
positive regulation of B cell proliferation
negative regulation of inflammatory response
negative regulation of neuroinflammatory response
T cell activation
positive regulation of T cell proliferation
negative regulation of tumor necrosis factor biosynthetic process
positive regulation of MHC class II biosynthetic process
cholesterol metabolic process
neuroinflammatory response
positive regulation of macroautophagy
positive regulation of amyloid-beta clearance
B cell differentiation
positive regulation of ATP biosynthetic process
positive regulation of receptor-mediated endocytosis
positive regulation of cellular respiration
positive regulation of isotype switching to IgG isotypes
positive regulation of cold-induced thermogenesis
positive regulation of tyrosine phosphorylation of STAT protein
negative regulation of transcription, DNA-dependent
positive regulation of interleukin-10 secretion
positive regulation of transcription, DNA-dependent
positive regulation of interleukin-13 production
activation of Janus kinase activity
immune response
positive regulation of isotype switching to IgE isotypes
connective tissue growth factor biosynthetic process
Cellular Component
extracellular region
extracellular space
Molecular Function
growth factor activity
cytokine activity
interleukin-4 receptor binding
Cellular Location
  1. Secreted
Pathways
Gene Properties
Chromosome Location 5
Locus 5q31.1
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 153
Molecular Weight 17492.09
Theoretical pI Not Available
Pfam Domain Function
Signals
  • ["1-24"]
Transmembrane Regions Not Available
Protein Sequence 
>Interleukin-4
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAAS
KNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGL
NSCPVKEANQSTLENFLERLKTIMREKYSKCSS
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P05112
UniProtKB/Swiss-Prot Entry Name IL4_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:6014
References
General References Not Available