Cannabis Compound Database: Showing Compound Card for Pyridoxal 5'-phosphate (CDB005196)

Jump To Section:

Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (79) Show 85 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 19:18:58 UTC

Updated at

2020-11-18 16:39:30 UTC

CannabisDB ID

CDB005196

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Pyridoxal 5'-phosphate

Description

Pyridoxal 5'-phosphate, also known as PLP or codecarboxylase, belongs to the class of organic compounds known as pyridoxals and derivatives. Pyridoxals and derivatives are compounds containing a pyridoxal moiety, which consists of a pyridine ring substituted at positions 2,3,4, and 5 by a methyl group, a hydroxyl group, a carbaldehyde group, and a hydroxymethyl group, respectively. Pyridoxal 5'-phosphate is a drug which is used for nutritional supplementation and for treating dietary shortage or imbalance. Pyridoxal 5'-phosphate is a strong basic compound (based on its pKa). Pyridoxal 5'-phosphate exists in all living species, ranging from bacteria to humans. In humans, pyridoxal 5'-phosphate is involved in glycine and serine metabolism. Outside of the human body, Pyridoxal 5'-phosphate is found, on average, in the highest concentration within milk (cow). Pyridoxal 5'-phosphate has also been detected, but not quantified in, several different foods, such as soursops, italian sweet red peppers, muscadine grapes, european plums, and blackcurrants. This could make pyridoxal 5'-phosphate a potential biomarker for the consumption of these foods. The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal. Pyridoxal 5'-phosphate is a potentially toxic compound. Pyridoxal 5'-phosphate, with regard to humans, has been found to be associated with several diseases such as epilepsy, early-onset, vitamin b6-dependent, odontohypophosphatasia, pyridoxamine 5-prime-phosphate oxidase deficiency, and hypophosphatasia; pyridoxal 5'-phosphate has also been linked to the inborn metabolic disorder celiac disease. Pyridoxal 5'-phosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
3-Hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde	ChEBI
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate	ChEBI
Codecarboxylase	ChEBI
Phosphoric acid mono-(4-formyl-5-hydroxy-6-methyl-pyridin-3-ylmethyl) ester	ChEBI
PLP	ChEBI
Pyridoxal 5'-(dihydrogen phosphate)	ChEBI
Pyridoxal 5-monophosphoric acid ester	ChEBI
Pyridoxal 5-phosphate	ChEBI
Pyridoxal phosphate	ChEBI
PYRIDOXAL-5'-phosphATE	ChEBI
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphoric acid	Generator
Phosphate mono-(4-formyl-5-hydroxy-6-methyl-pyridin-3-ylmethyl) ester	Generator
Pyridoxal 5'-(dihydrogen phosphoric acid)	Generator
Pyridoxal 5-monophosphate ester	Generator
Pyridoxal 5-phosphoric acid	Generator
Pyridoxal phosphoric acid	Generator
PYRIDOXAL-5'-phosphoric acid	Generator
Pyridoxal 5'-phosphoric acid	Generator
Apolon b6	HMDB
Biosechs	HMDB
Coenzyme b6	HMDB
Hairoxal	HMDB
Hexermin-p	HMDB
Hi-pyridoxin	HMDB
Hiadelon	HMDB
Himitan	HMDB
PAL-p	HMDB
Phosphopyridoxal	HMDB
Phosphopyridoxal coenzyme	HMDB
Pidopidon	HMDB
Piodel	HMDB
Pydoxal	HMDB
Pyridoxal p	HMDB
Pyridoxal-p	HMDB
Pyridoxyl phosphate	HMDB
Pyromijin	HMDB
Sechvitan	HMDB
Vitahexin-p	HMDB
Vitazechs	HMDB
Phosphate, pyridoxal	HMDB
Pyridoxal 5 phosphate	HMDB

Chemical Formula

C₈H₁₀NO₆P

Average Molecular Weight

247.14

Monoisotopic Molecular Weight

247.0246

IUPAC Name

[(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methoxy]phosphonic acid

Traditional Name

pyridoxal phosphate

CAS Registry Number

54-47-7

SMILES

CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O

InChI Identifier

InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)

InChI Key

NGVDGCNFYWLIFO-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pyridoxals and derivatives. Pyridoxals and derivatives are compounds containing a pyridoxal moiety, which consists of a pyridine ring substituted at positions 2,3,4, and 5 by a methyl group, a hydroxyl group, a carbaldehyde group, and a hydroxymethyl group, respectively.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyridines and derivatives

Sub Class

Pyridine carboxaldehydes

Direct Parent

Pyridoxals and derivatives

Alternative Parents

Substituents

Pyridoxal
Aryl-aldehyde
Monoalkyl phosphate
Hydroxypyridine
Methylpyridine
Organic phosphoric acid derivative
Phosphoric acid ester
Alkyl phosphate
Vinylogous acid
Heteroaromatic compound
Azacycle
Organopnictogen compound
Aldehyde
Organic oxygen compound
Organic nitrogen compound
Organooxygen compound
Organonitrogen compound
Hydrocarbon derivative
Organic oxide
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

monohydroxypyridine (CHEBI:18405 )
pyridinecarbaldehyde (CHEBI:18405 )
methylpyridines (CHEBI:18405 )
vitamin B6 phosphate (CHEBI:18405 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Plant:

Animal

Biological location:

Organ and components:

Tissue and substructures:

Muscle

Cell and elements:

Cell:

Nerve cell

Subcellular:

Biofluid and excreta:

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	255 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	28 mg/mL	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.55	ALOGPS
logP	-2.1	ChemAxon
logS	-1.6	ALOGPS
pKa (Strongest Acidic)	1.68	ChemAxon
pKa (Strongest Basic)	4.11	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	116.95 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	54.75 m³·mol⁻¹	ChemAxon
Polarizability	20.9 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	Pyridoxal 5'-phosphate, 1 MEOX; 3 TMS, GC-MS Spectrum	splash10-0gb9-2690000000-c9bacb7e657461e28407	Spectrum
GC-MS	Pyridoxal 5'-phosphate, non-derivatized, GC-MS Spectrum	splash10-0gb9-2690000000-c9bacb7e657461e28407	Spectrum
GC-MS	Pyridoxal 5'-phosphate, non-derivatized, GC-MS Spectrum	splash10-004j-0910000000-0408f3957221fc9882cd	Spectrum
GC-MS	Pyridoxal 5'-phosphate, non-derivatized, GC-MS Spectrum	splash10-0gb9-1790000000-b01115fa8b4cfd3612c7	Spectrum
Predicted GC-MS	Pyridoxal 5'-phosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0002-9520000000-bfd574b2e5355694902a	Spectrum
Predicted GC-MS	Pyridoxal 5'-phosphate, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-006t-9152000000-26c9f631195663322986	Spectrum
Predicted GC-MS	Pyridoxal 5'-phosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0f6t-0690000000-4aa57f3f28f0bdef9dcf	Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0fxx-8900000000-ee972556340c61650528	Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-014l-9100000000-3cc29fb51820adecd59c	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0002-0090000000-9b86e80a9dd0de14ab59	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-03dj-9800000000-9313aa9cbf19bc6311c5	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-0002-9500000000-7ce120a58879e2214ce5	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-004j-9200000000-7e6bd8c298613e59fb5d	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-004i-9000000000-4c05178b1645bf01f3fa	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-0udi-3920000000-6c5e6106f5658d1d6c50	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-0udi-3920000000-f96097815e6922356131	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-002b-9000000000-2c4e243699a95e3a0f88	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-002b-9000000000-8aa111485891af9f0d02	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0002-0090000000-9b86e80a9dd0de14ab59	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-03dj-9800000000-9313aa9cbf19bc6311c5	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0002-9500000000-7ce120a58879e2214ce5	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-004j-9200000000-7e6bd8c298613e59fb5d	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-004i-9000000000-4c05178b1645bf01f3fa	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-002b-9000000000-2c4e243699a95e3a0f88	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , negative	splash10-002b-9000000000-8aa111485891af9f0d02	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0f6t-1790000000-1dcb07cd1110c71f7005	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-0900000000-ca6aab7f31a36863a417	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0udi-9800000000-053802b9c0533d7943ea	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0002-9080000000-12ca63d34d39d59f6b42	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-004i-9000000000-144099ec201adbbc4684	Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9000000000-70a9559d65e78c488e7e	Spectrum

NMR

Type	Description	View
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
2D NMR	[1H,1H] 2D NMR Spectrum	Spectrum
2D NMR	[1H,13C] 2D NMR Spectrum	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glucose-Alanine Cycle		Not Available
Malate-Aspartate Shuttle		Not Available
Vitamin B6 Metabolism
Alanine Metabolism
Primary Hyperoxaluria Type I		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	Xp11.21	P22557	details
5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	3p21.1	P13196	details
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	22q13.1	O75600	details
Methylenetetrahydrofolate reductase	MTHFR	1p36.3	P42898	details
4-aminobutyrate aminotransferase, mitochondrial	ABAT	16p13.2	P80404	details
Tyrosine aminotransferase	TAT	16q22.1	P17735	details
Aromatic-L-amino-acid decarboxylase	DDC	7p12.2	P20711	details
Aspartate aminotransferase, cytoplasmic	GOT1	10q24.1-q25.1	P17174	details
Aspartate aminotransferase, mitochondrial	GOT2	16q21	P00505	details
Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	12p12.1	P54687	details
Kynureninase	KYNU	2q22.2	Q16719	details
Glucose-6-phosphate 1-dehydrogenase	G6PD	Xq28	P11413	details
Glycogen phosphorylase, liver form	PYGL	14q21-q22	P06737	details
Glycogen phosphorylase, muscle form	PYGM	11q12-q13.2	P11217	details
Glycogen phosphorylase, brain form	PYGB	20p11.21	P11216	details
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	AADAT	4q33	Q8N5Z0	details
Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	5p13	Q9BYV1	details
Ornithine aminotransferase, mitochondrial	OAT	10q26	P04181	details
Kynurenine--oxoglutarate transaminase 1	CCBL1	9q34.11	Q16773	details
Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	19q13	O15382	details
Cystathionine gamma-lyase	CTH	1p31.1	P32929	details
L-serine dehydratase/L-threonine deaminase	SDS	12q24.13	P20132	details
Pyridoxine-5'-phosphate oxidase	PNPO	17q21.32	Q9NVS9	details
Formimidoyltransferase-cyclodeaminase	FTCD	21q22.3	O95954	details
Glutamate decarboxylase 2	GAD2	10p11.23	Q05329	details
Glutamate decarboxylase 1	GAD1	2q31	Q99259	details
Cystathionine beta-synthase	CBS	21q22.3	P35520	details
Serine--pyruvate aminotransferase	AGXT	2q37.3	P21549	details
Serine hydroxymethyltransferase, mitochondrial	SHMT2	12q12-q14	P34897	details
Serine hydroxymethyltransferase, cytosolic	SHMT1	17p11.2	P34896	details
Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	9p22	P23378	details
Alanine aminotransferase 1	GPT	8q24.3	P24298	details
Phosphoserine aminotransferase	PSAT1	9q21.2	Q9Y617	details
Histidine decarboxylase	HDC	15q21-q22	P19113	details
Serine palmitoyltransferase 1	SPTLC1	9q22.2	O15269	details
Serine palmitoyltransferase 2	SPTLC2	14q24.3	O15270	details
Cysteine sulfinic acid decarboxylase	CSAD	12q13.11-q14.3	Q9Y600	details
Ornithine decarboxylase	ODC1	2p25	P11926	details
Sphingosine-1-phosphate lyase 1	SGPL1	10q21	O95470	details
Pyridoxal kinase	PDXK	21q22.3	O00764	details
Arginine decarboxylase	ADC	1p35.1	Q96A70	details
Phosphatidylserine decarboxylase proenzyme	PISD	22q12.2	Q9UG56	details
Cysteine desulfurase, mitochondrial	NFS1	20q11.22	Q9Y697	details
Proline synthase co-transcribed bacterial homolog protein	PROSC	8p11.2	O94903	details
Aminoadipate aminotransferase, isoform CRA_b	AADAT	4q33	Q4W5N8	details
Threonine synthase-like 1	THNSL1	10p12.1	Q8IYQ7	details
Ethanolamine-phosphate phospho-lyase	AGXT2L1	4q25	Q8TBG4	details
Alanine aminotransferase 2	GPT2	16q12.1	Q8TD30	details
Pyridoxal phosphate phosphatase	PDXP	22q12.3	Q96GD0	details
Selenocysteine lyase	SCLY	2q37.3	Q96I15	details
Pyridoxal phosphate phosphatase PHOSPHO2	PHOSPHO2	2q31.1	Q8TCD6	details
Putative aspartate aminotransferase, cytoplasmic 2	GOT1L1	8p11.23	Q8NHS2	details
5-phosphohydroxy-L-lysine phospho-lyase	AGXT2L2	5q35.3	Q8IUZ5	details
Glutamate decarboxylase-like protein 1	GADL1	3p24.1-p23	Q6ZQY3	details
Kynurenine--oxoglutarate transaminase 3	CCBL2	1p22.2	Q6YP21	details
Molybdenum cofactor sulfurase	MOCOS	18q12	Q96EN8	details
Pyridoxal-dependent decarboxylase domain-containing protein 1	PDXDC1	16p13.11	Q6P996	details
Pyridoxal-dependent decarboxylase domain-containing protein 2	PDXDC2	16q22.1	Q6P474	details
Serine dehydratase-like	SDSL	12q24.13	Q96GA7	details
O-phosphoseryl-tRNA(Sec) selenium transferase	SEPSECS	4p15.2	Q9HD40	details
Serine palmitoyltransferase 3	SPTLC3	20p12.1	Q9NUV7	details
Serine racemase	SRR	17p13	Q9GZT4	details
Threonine synthase-like 2	THNSL2	2p11.2	Q86YJ6	details
Serine hydroxymethyltransferase	SHMT1	17p11.2	A8MYA6	details
Aspartate aminotransferase	GIG18		Q2TU84	details
GAD1 protein	GAD1	2q31	Q49AK1	details
Dopa decarboxylase (Aromatic L-amino acid decarboxylase)	DDC	7p12.2	Q53Y41	details
Phosphorylase			Q59GM9	details
Aminolevulinate, delta-, synthase 1, isoform CRA_a	ALAS1	3p21.1	Q5JAM2	details
Aminolevulinate, delta-, synthase 2	ALAS2		Q5JZF5	details
Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)	GAD2	10p11.23	Q5VZ29	details
Putative L-Dopa decarboxylase	DDC	7p12.2	Q5W5T9	details
DDC protein	DDC	7p12.2	Q6IBS8	details
CSAD protein	CSAD	12q13.11-q14.3	Q86V02	details
PDXDC1 protein	PDXDC1	16p13.11	Q86XE2	details
Glutamate decarboxylase 1 (Brain, 67kDa)	GAD1	2q31	Q8IVA8	details
P-selectin cytoplasmic tail-associated protein (PCAP)	pcap	1q42.2-q43	Q96JQ3	details
Glutamic acid decarboxylase	GAD65		Q9UGI5	details
Cysteine sulfinic acid decarboxylase, isoform CRA_c	CSAD	12q13.11-q14.3	Q9Y602	details

Transporters

Not Available

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Cystathionine beta-synthase	CBS	21q22.3	P35520	details
Pyridoxal phosphate phosphatase	PDXP	22q12.3	Q96GD0	details
Pyridoxal phosphate phosphatase PHOSPHO2	PHOSPHO2	2q31.1	Q8TCD6	details
Molybdenum cofactor sulfurase	MOCOS	18q12	Q96EN8	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Sphingosine-1-phosphate lyase 1	SGPL1	10q21	O95470	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Cystathionine gamma-lyase	CTH	1p31.1	P32929	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0001491

DrugBank ID

DB00114

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

18405

References

General References

Not Available

Only showing the first 10 proteins. There are 85 proteins in total.

Show All

Enzymes

Enzyme Details

1. 5-aminolevulinate synthase, erythroid-specific, mitochondrial

General function:: Involved in 5-aminolevulinate synthase activity
Specific function:: Not Available
Gene Name:: ALAS2
Uniprot ID:: P22557
Molecular weight:: 64632.86

Enzyme Details

2. 5-aminolevulinate synthase, nonspecific, mitochondrial

General function:: Involved in 5-aminolevulinate synthase activity
Specific function:: Not Available
Gene Name:: ALAS1
Uniprot ID:: P13196
Molecular weight:: 70580.325

Enzyme Details

3. 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

General function:: Involved in glycine C-acetyltransferase activity
Specific function:: Not Available
Gene Name:: GCAT
Uniprot ID:: O75600
Molecular weight:: 47973.79

Enzyme Details

4. Methylenetetrahydrofolate reductase

General function:: Involved in methylenetetrahydrofolate reductase (NADPH) activity
Specific function:: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
Gene Name:: MTHFR
Uniprot ID:: P42898
Molecular weight:: 74595.895

Enzyme Details

5. 4-aminobutyrate aminotransferase, mitochondrial

General function:: Involved in 4-aminobutyrate transaminase activity
Specific function:: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Gene Name:: ABAT
Uniprot ID:: P80404
Molecular weight:: 56438.405

Enzyme Details

6. Tyrosine aminotransferase

General function:: Involved in 1-aminocyclopropane-1-carboxylate synthase activity
Specific function:: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.
Gene Name:: TAT
Uniprot ID:: P17735
Molecular weight:: 50398.895

Enzyme Details

7. Aromatic-L-amino-acid decarboxylase

General function:: Involved in carboxy-lyase activity
Specific function:: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Gene Name:: DDC
Uniprot ID:: P20711
Molecular weight:: 53893.755

Enzyme Details

8. Aspartate aminotransferase, cytoplasmic

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Plays a key role in amino acid metabolism (By similarity).
Gene Name:: GOT1
Uniprot ID:: P17174
Molecular weight:: 46247.14

Enzyme Details

9. Aspartate aminotransferase, mitochondrial

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
Gene Name:: GOT2
Uniprot ID:: P00505
Molecular weight:: 47517.285

Enzyme Details

10. Branched-chain-amino-acid aminotransferase, cytosolic

General function:: Involved in catalytic activity
Specific function:: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Gene Name:: BCAT1
Uniprot ID:: P54687
Molecular weight:: 38644.77

Only showing the first 10 proteins. There are 85 proteins in total.

Show All

Showing Compound Card for Pyridoxal 5'-phosphate (CDB005196)

Structure for CDB005196 (Pyridoxal 5'-phosphate)

Enzymes