| Identification |
|---|
| HMDB Protein ID
| CDBP00322 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glucose-6-phosphate 1-dehydrogenase |
| Description
| Not Available |
| Synonyms
|
- G6PD
|
| Gene Name
| G6PD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in glucose-6-phosphate dehydrogenase activity |
| Specific Function
| Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power.
|
| GO Classification
|
| Biological Process |
| glucose 6-phosphate metabolic process |
| negative regulation of protein glutathionylation |
| ribose phosphate biosynthetic process |
| cytokine production |
| glutathione metabolic process |
| erythrocyte maturation |
| cellular response to oxidative stress |
| pentose biosynthetic process |
| pentose-phosphate shunt, oxidative branch |
| cholesterol biosynthetic process |
| Cellular Component |
| cytosol |
| centrosome |
| internal side of plasma membrane |
| intracellular membrane-bounded organelle |
| Function |
| nadp or nadph binding |
| oxidoreductase activity, acting on ch-oh group of donors |
| oxidoreductase activity |
| binding |
| nucleotide binding |
| catalytic activity |
| oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor |
| glucose-6-phosphate dehydrogenase activity |
| Molecular Function |
| NADP binding |
| glucose binding |
| glucose-6-phosphate dehydrogenase activity |
| Process |
| metabolic process |
| small molecule metabolic process |
| alcohol metabolic process |
| monosaccharide metabolic process |
| hexose metabolic process |
| glucose metabolic process |
| oxidation reduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Pentose Phosphate Pathway |    |  | | Glucose-6-phosphate dehydrogenase deficiency |    | Not Available | | Ribose-5-phosphate isomerase deficiency |    | Not Available | | Transaldolase deficiency |    | Not Available | | Warburg Effect |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Xq28 |
| SNPs
| G6PD |
| Gene Sequence
|
>1548 bp
ATGGCAGAGCAGGTGGCCCTGAGCCGGACCCACGTGTGCGGGATCCTGCGGGAAGAGCTT
TTCCAGGGCGATGCCTTCCATCAGTCGGATACACACATATTCATCATCATGGGTGCATCG
GGTGACCTGGCCAAGAAGAAGATCTACCCCACCATCTGGTGGCTGTTCCGGGATGGCCTT
CTGCCCGAAAACACCTTCATCGTGGGCTATGCCCGTTCCCGCCTCACAGTGGCTGACATC
CGCAAACAGAGTGAGCCCTTCTTCAAGGCCACCCCAGAGGAGAAGCTCAAGCTGGAGGAC
TTCTTTGCCCGCAACTCCTATGTGGCTGGCCAGTACGATGATGCAGCCTCCTACCAGCGC
CTCAACAGCCACATGAATGCCCTCCACCTGGGGTCACAGGCCAACCGCCTCTTCTACCTG
GCCTTGCCCCCGACCGTCTACGAGGCCGTCACCAAGAACATTCACGAGTCCTGCATGAGC
CAGATAGGCTGGAACCGCATCATCGTGGAGAAGCCCTTCGGGAGGGACCTGCAGAGCTCT
GACCGGCTGTCCAACCACATCTCCTCCCTGTTCCGTGAGGACCAGATCTACCGCATCGAC
CACTACCTGGGCAAGGAGATGGTGCAGAACCTCATGGTGCTGAGATTTGCCAACAGGATC
TTCGGCCCCATCTGGAACCGGGACAACATCGCCTGCGTTATCCTCACCTTCAAGGAGCCC
TTTGGCACTGAGGGTCGCGGGGGCTATTTCGATGAATTTGGGATCATCCGGGACGTGATG
CAGAACCACCTACTGCAGATGCTGTGTCTGGTGGCCATGGAGAAGCCCGCCTCCACCAAC
TCAGATGACGTCCGTGATGAGAAGGTCAAGGTGTTGAAATGCATCTCAGAGGTGCAGGCC
AACAATGTGGTCCTGGGCCAGTACGTGGGGAACCCCGATGGAGAGGGCGAGGCCACCAAA
GGGTACCTGGACGACCCCACGGTGCCCCGCGGGTCCACCACCGCCACTTTTGCAGCCGTC
GTCCTCTATGTGGAGAATGAGAGGTGGGATGGGGTGCCCTTCATCCTGCGCTGCGGCAAG
GCCCTGAACGAGCGCAAGGCCGAGGTGAGGCTGCAGTTCCATGATGTGGCCGGCGACATC
TTCCACCAGCAGTGCAAGCGCAACGAGCTGGTGATCCGCGTGCAGCCCAACGAGGCCGTG
TACACCAAGATGATGACCAAGAAGCCGGGCATGTTCTTCAACCCCGAGGAGTCGGAGCTG
GACCTGACCTACGGCAACAGATACAAGAACGTGAAGCTCCCTGACGCCTACGAGCGCCTC
ATCCTGGACGTCTTCTGCGGGAGCCAGATGCACTTCGTGCGCAGCGACGAGCTCCGTGAG
GCCTGGCGTATTTTCACCCCACTGCTGCACCAGATTGAGCTGGAGAAGCCCAAGCCCATC
CCCTATATTTATGGCAGCCGAGGCCCCACGGAGGCAGACGAGCTGATGAAGAGAGTGGGT
TTCCAGTATGAGGGCACCTACAAGTGGGTGAACCCCCACAAGCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 515 |
| Molecular Weight
| 62467.88 |
| Theoretical pI
| 8.039 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glucose-6-phosphate 1-dehydrogenase
MAEQVALSRTQVCGILREELFQGDAFHQSDTHIFIIMGASGDLAKKKIYPTIWWLFRDGL
LPENTFIVGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQR
LNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSS
DRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEP
FGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKVLKCISEVQA
NNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWDGVPFILRCGK
ALNERKAEVRLQFHDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESEL
DLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIELEKPKPI
PYIYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
|
| External Links |
|---|
| GenBank ID Protein
| 31543 |
| UniProtKB/Swiss-Prot ID
| P11413 |
| UniProtKB/Swiss-Prot Entry Name
| G6PD_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X03674 |
| GeneCard ID
| G6PD |
| GenAtlas ID
| G6PD |
| HGNC ID
| HGNC:4057 |
| References |
|---|
| General References
| Not Available |