Cannabis Compound Database: Showing Protein Molybdenum cofactor sulfurase (CDBP04175)

Identification Biological properties Gene properties Protein properties External links References XML Show 6 compounds

Identification

HMDB Protein ID

CDBP04175

Secondary Accession Numbers

Not Available

Name

Molybdenum cofactor sulfurase

Description

Not Available

Synonyms

MCS
MOS
MoCo sulfurase
hMCS

Gene Name

MOCOS

Protein Type

Enzyme

Biological Properties

General Function

Involved in metabolic process

Specific Function

Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime.

GO Classification

Biological Process
molybdopterin cofactor biosynthetic process
water-soluble vitamin metabolic process
Mo-molybdopterin cofactor biosynthetic process
Cellular Component
cytosol
Function
pyridoxal phosphate binding
molybdenum ion binding
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
cofactor binding
Molecular Function
Mo-molybdopterin cofactor sulfurase activity
molybdenum ion binding
transferase activity
pyridoxal phosphate binding
Process
metabolic process

Cellular Location

Not Available

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

18q12

SNPs

MOCOS

Gene Sequence

>2667 bp
ATGGCCGGCGCGGCGGCGGAGTCAGGGCGGGAGCTGTGGACCTTCGCGGGTTCCCGGGAC
CCGAGCGCACCGCGGCTAGCCTACGGCTACGGCCCGGGCAGCCTGCGCGAGCTGCGGGCG
CGCGAGTTCAGCCGCCTGGCAGGAACTGTCTATCTTGACCATGCAGGTGCCACCTTGTTC
TCCCAGAGCCAGCTCGAAAGCTTCACTAGTGATCTCATGGAAAACACTTATGGTAATCCT
CACAGCCAGAACATCAGCAGCAAGCTCACCCATGACACTGTGGAGCAGGTGCGCTACAGA
ATCCTGGCGCACTTCCACACCACCGCAGAAGACTACACTGTGATCTTCACTGCCGGGAGC
ACGGCTGCTCTCAAACTGGTGGCAGAGGCCTTTCCATGGGTGTCCCAGGGCCCAGAGAGC
AGTGGGAGTCGCTTCTGTTACCTCACCGACAGCCACACCTCCGTAGTGGGTATGCGGAAC
GTGACCATGGCTATAAATGTCATATCCACCCCGGTCAGGCCAGAGGACCTGTGGTCTGCA
GAGGAACGTAGTGCTTCAGCCAGCAACCCAGACTGCCAGCTGCCGCATCTCTTCTGCTAC
CCAGCTCAGAGTAACTTTTCTGGAGTCAGATACCCCCTGTCCTGGATAGAAGAGGTCAAG
TCTGGGCGGTTGCACCCTGTGAGCACGCCTGGGAAGTGGTTTGTGCTGCTGGATGCAGCC
TCCTACGTGAGCACCTCGCCTTTGGACCTGTCAGCTCACCAGGCCGACTTTGTCCCCATC
TCCTTCTATAAGATCTTCGGGTTTCCTACAGGCCTGGGCGCTCTGCTGGTCCATAATCGT
GCGGCTCCTCTACTGAGGAAGACCTACTTTGGAGGAGGGACAGCCTCTGCGTACCTAGCA
GGAGAAGACTTCTACATCCCGAGGCAGTCGGTAGCTCAGAGGTTTGAAGATGGCACCATC
TCATTCCTTGATGTTATCGCGCTAAAACATGGATTTGACACCCTAGAGCGCCTCACAGGT
GGAATGGAGAATATAAAGCAGCACACCTTCACCTTGGCTCAGTATACCTACGTGGCCCTG
TCCTCTCTCCAGTACCCCAATGGAGCCCCTGTGGTGCGGATTTACAGCGATTCTGAGTTC
AGCAGCCCTGAGGTTCAGGGCCCAATCATCAATTTTAATGTGCTGGATGACAAAGGGAAC
ATCATTGGTTACTCCCAGGTGGACAAAATGGCCAGTCTTTACAACATCCACCTGCGAACT
GGCTGCTTCTGTAACACTGGGGCCTGCCAGAGGCACCTGGGCATAAGCAACGAGATGGTC
AGGAAGCATTTTCAGGCTGGTCATGTCTGTGGGGACAATATGGACCTCATAGATGGGCAG
CCCACAGGATCTGTGAGGATTTCATTTGGATACATGTCGACGCTGGATGATGTCCAGGCC
TTTCTTAGGTTCATCATAGACACTCGCCTGCACTCATCAGGGGACTGGCCTGTCCCTCAG
GCCCATGCTGACACCGGGGAGACTGGAGCCCCATCAGCAGACAGCCAGGCTGATGTTATA
CCTGCTGTCATGGGCAGACGTAGCCTCTCGCCTCAGGAAGATGCCCTCACAGGCTCCAGG
GTTTGGAACAACTCGTCTACTGTGAATGCTGTGCCTGTGGCCCCACCTGTGTGTGATGTC
GCCAGAACCCAGCCGACTCCTTCAGAGAAAGCTGCAGGAGTCCTGGAGGGGGCCCTTGGG
CCACATGTTGTCACTAACCTTTATCTCTATCCAATCAAATCCTGTGCTGCATTTGAGGTG
ACCAGGTGGCCTGTAGGAAACCAAGGGCTGCTATATGACCGGAGCTGGATGGTTGTGAAT
CACAATGGTGTTTGCCTGAGTCAGAAGCAGGAACCCCGGCTCTGCCTGATCCAGCCCTTC
ATCGACTTGCGGCAAAGGATCATGGTCATCAAAGCCAAAGGGATGGAGCCTATAGAGGTG
CCTCTTGAGGAAAATAGTGAACGGACTCAGATTCGCCAAAGCAGGGTCTGTGCTGACAGA
GTAAGTACTTATGATTGTGGAGAAAAAATTTCAAGCTGGTTGTCAACATTTTTTGGCCGT
CCTTGTCATTTGATCAAACAAAGTTCAAACTCTCAAAGGAATGCAAAGAAGAAACATGGA
AAAGATCAACTTCCTGGTACAATGGCCACCCTTTCTCTGGTGAATGAGGCACAGTATCTG
CTGATCAACACATCCAGTATTTTGGAACTTCACCGGCAACTAAACACCAGTGATGAGAAT
GGAAAGGAGGAATTATTCTCACTGAAGGATCTCAGCTTGCGTTTTCGTGCCAATATTATT
ATCAATGGAAAAAGGGCTTTTGAAGAAGAGAAATGGGATGAGATTTCAATTGGCTCTTTG
CGTTTCCAGGTTTTGGGGCCTTGTCACAGATGCCAGATGATTTGCATCGACCAGCAAACT
GGGCAACGAAACCAGCATGTTTTCCAAAAACTTTCTGAGAGTCGTGAAACAAAGGTGAAC
TTTGGCATGTACCTGATGCATGCATCATTGGATTTATCCTCCCCATGTTTCCTGTCTGTA
GGATCTCAGGTGCTCCCTGTGTTGAAAGAGAATGTGGAAGGTCATGATTTACCTGCATCT
GAGAAACACCAGGATGTTACCTCCTAA

Protein Properties

Number of Residues

888

Molecular Weight

98118.965

Theoretical pI

6.696

Pfam Domain Function

Aminotran_5 (PF00266 )
MOSC (PF03473 )
MOSC_N (PF03476 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Molybdenum cofactor sulfurase
MAGAAAESGRELWTFAGSRDPSAPRLAYGYGPGSLRELRAREFSRLAGTVYLDHAGATLF
SQSQLESFTSDLMENTYGNPHSQNISSKLTHDTVEQVRYRILAHFHTTAEDYTVIFTAGS
TAALKLVAEAFPWVSQGPESSGSRFCYLTDSHTSVVGMRNVTMAINVISTPVRPEDLWSA
EERSASASNPDCQLPHLFCYPAQSNFSGVRYPLSWIEEVKSGRLHPVSTPGKWFVLLDAA
SYVSTSPLDLSAHQADFVPISFYKIFGFPTGLGALLVHNRAAPLLRKTYFGGGTASAYLA
GEDFYIPRQSVAQRFEDGTISFLDVIALKHGFDTLERLTGGMENIKQHTFTLAQYTYVAL
SSLQYPNGAPVVRIYSDSEFSSPEVQGPIINFNVLDDKGNIIGYSQVDKMASLYNIHLRT
GCFCNTGACQRHLGISNEMVRKHFQAGHVCGDNMDLIDGQPTGSVRISFGYMSTLDDVQA
FLRFIIDTRLHSSGDWPVPQAHADTGETGAPSADSQADVIPAVMGRRSLSPQEDALTGSR
VWNNSSTVNAVPVAPPVCDVARTQPTPSEKAAGVLEGALGPHVVTNLYLYPIKSCAAFEV
TRWPVGNQGLLYDRSWMVVNHNGVCLSQKQEPRLCLIQPFIDLRQRIMVIKAKGMEPIEV
PLEENSERTQIRQSRVCADRVSTYDCGEKISSWLSTFFGRPCHLIKQSSNSQRNAKKKHG
KDQLPGTMATLSLVNEAQYLLINTSSILELHRQLNTSDENGKEELFSLKDLSLRFRANII
INGKRAFEEEKWDEISIGSLRFQVLGPCHRCQMICIDQQTGQRNQHVFQKLSESRETKVN
FGMYLMHASLDLSSPCFLSVGSQVLPVLKENVEGHDLPASEKHQDVTS

External Links

GenBank ID Protein

157388923

UniProtKB/Swiss-Prot ID

Q96EN8

UniProtKB/Swiss-Prot Entry Name

MOCOS_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_017947.2

GeneCard ID