| Identification |
|---|
| HMDB Protein ID
| CDBP00734 |
| Secondary Accession Numbers
| Not Available |
| Name
| Serine--pyruvate aminotransferase |
| Description
| Not Available |
| Synonyms
|
- AGT
- Alanine--glyoxylate aminotransferase
- SPT
|
| Gene Name
| AGXT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metabolic process |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| glyoxylate catabolic process |
| response to glucocorticoid stimulus |
| pyruvate biosynthetic process |
| response to cAMP |
| L-cysteine catabolic process |
| L-alanine catabolic process |
| cellular nitrogen compound metabolic process |
| oxalic acid secretion |
| protein targeting to peroxisome |
| glycine biosynthetic process, by transamination of glyoxylate |
| Cellular Component |
| mitochondrial matrix |
| peroxisomal matrix |
| Molecular Function |
| serine-pyruvate transaminase activity |
| pyridoxal phosphate binding |
| alanine-glyoxylate transaminase activity |
| protein homodimerization activity |
| amino acid binding |
| Process |
| metabolic process |
|
| Cellular Location
|
- Mitochondrion matrix
- Peroxisome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Alanine, aspartate and glutamate metabolism | Not Available |  | | Glycine, serine and threonine metabolism | Not Available |  | | Glyoxylate and dicarboxylate metabolism | Not Available |  | | Peroxisome | Not Available |  | | Alanine Metabolism |    | |
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q37.3 |
| SNPs
| AGXT |
| Gene Sequence
|
>1179 bp
ATGGCCTCTCACAAGCTGCTGGTGACCCCCCCCAAGGCCCTGCTCAAGCCCCTCTCCATC
CCCAACCAGCTCCTGCTGGGGCCTGGTCCTTCCAACCTGCCTCCTCGCATCATGGCAGCC
GGGGGGCTGCAGATGATCGGGTCCATGAGCAAGGATATGTACCAGATCATGGACGAGATC
AAGGAAGGCATCCAGTACGTGTTCCAGACCAGGAACCCACTCACACTGGTCATCTCTGGC
TCGGGACACTGTGCCCTGGAGGCCGCCCTGGTCAATGTGCTGGAGCCTGGGGACTCCTTC
CTGGTTGGGGCCAATGGCATTTGGGGGCAGCGAGCCGTGGACATCGGGGAGCGCATAGGA
GCCCGAGTGCACCCGATGACCAAGGACCCTGGAGGCCACTACACACTGCAGGAGGTGGAG
GAGGGCCTGGCCCAGCACAAGCCAGTGCTGCTGTTCTTAACCCACGGGGAGTCGTCCACC
GGCGTGCTGCAGCCCCTTGATGGCTTCGGGGAACTCTGCCACAGGTACAAGTGCCTGCTC
CTGGTGGATTCGGTGGCATCCCTGGGCGGGACCCCCCTTTACATGGACCGGCAAGGCATC
GACATCCTGTACTCGGGCTCCCAGAAGGCCCTGAACGCCCCTCCAGGGACCTCGCTCATC
TCCTTCAGTGACAAGGCCAAAAAGAAGATGTACTCCCGCAAGACGAAGCCCTTCTCCTTC
TACCTGGACATCAAGTGGCTGGCCAACTTCTGGGGCTGTGACGACCAGCCCAGGATGTAC
CATCACACAATCCCCGTCATCAGCCTGTACAGCCTGAGAGAGAGCCTGGCCCTCATTGCG
GAACAGGGCCTGGAGAACAGCTGGCGCCAGCACCGCGAGGCCGCGGCGTATCTGCATGGG
CGCCTGCAGGCACTGGGGCTGCAGCTCTTCGTGAAGGACCCGGCGCTCCGGCTTCCCACA
GTCACCACTGTGGCTGTACCCGCTGGCTATGACTGGAGAGACATCGTCAGCTACGTCATA
GACCACTTCGACATTGAGATCATGGGTGGCCTTGGGCCCTCCACGGGGAAGGTGCTGCGG
ATCGGCCTGCTGGGCTGCAATGCCACCCGCGAGAATGTGGACCGCGTGACGGAGGCCCTG
AGGGCGGCCCTGCAGCACTGCCCCAAGAAGAAGCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 392 |
| Molecular Weight
| 43009.535 |
| Theoretical pI
| 8.393 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine--pyruvate aminotransferase
MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEI
KEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG
ARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLL
LVDSVASLGGTPLYMDRQGIDILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSF
YLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG
RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLR
IGLLGCNATRENVDRVTEALRAALQHCPKKKL
|
| External Links |
|---|
| GenBank ID Protein
| 36582 |
| UniProtKB/Swiss-Prot ID
| P21549 |
| UniProtKB/Swiss-Prot Entry Name
| SPYA_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X56092 |
| GeneCard ID
| AGXT |
| GenAtlas ID
| AGXT |
| HGNC ID
| HGNC:341 |
| References |
|---|
| General References
| Not Available |